Abstract: A secure safe system with tamper detection includes an enclosure having an outer surface and an inner compartment accessible through a door, and a door lock mechanism. An access device is provided for unlocking the door lock mechanism, thereby enabling a user to gain access to the compartment. An electronic controller, disposed within the enclosure, is interconnected to the access device and the door lock mechanism. The controller is operative to receive a signal from the access device and unlock the door lock mechanism for an authorized user. The outer surface of the enclosure is touch sensitive, and the controller is further operative to determine if a person has touched the touch-sensitive surface and, if so, cause a safe-related function to be performed. The outer surface of the enclosure may be metallic or covered or coated with a touch-sensitive surface. The access device is also preferably touch-sensitive.