Abstract: An apparatus or method for forming a sterile connection. The apparatus includes at least two sterile tubes each disposed within a flange. Each flange has an external face that completely covers the mouth of the tube. Each flange is designed to be displaced when force is applied to the tube to move the tubes toward one another such that the external face of each flange is displaced radially or axially outwards away from the mouth of the tube. When the external faces are displaced, the external face of each flange opens and tubes connect and form a sterile connection therebetween.

Abstract: A method and a device are provided for contamination-free and/or sterile sealing between two interconnectable connecting elements having opposing openings. Interconnection allows transfer of a fluid between the openings. Sealing elements are arranged on the connecting elements around the openings, and protective films are provided, covering the sealing elements and the openings and adapted to be removed in the final interconnection. The sealing elements are each provided with at least one recess which extends wholly or partly around the associated opening and receives a gas. In use the sealing elements are moved into engagement with each other, interleaved with the protective films, to reduce the volume of the recesses and, thus, increase the pressure of the gas therein. During removal of the protective films, the gas flows out of the recesses to the environment to prevent penetration of contamination into the openings.

Abstract: A device in a valve (1) includes a valve housing (2) with at least a first (3) and a second (4) fluid port. A closure element (5) including a sealing portion (15) and diaphragm (30) is arranged in the valve housing (2). The sealing portion (15) is movable between an open position and a closed position. The closure element (5) and valve housing (2) form a flow passage (11) which communicates with the fluid ports when the sealing portion (15) leaves the closed position. A second sealing portion (14) is arranged in contact with a support portion (25) of the valve housing (2). An abutment element (16) is arranged in contact with the second sealing portion (14). The abutment element (16) transmits a force via the second sealing portion (14) toward the support portion (25) to provide a seal. The force is at least partly exerted by a spring element.

Abstract: A method and a device are provided for interconnecting, sealed against contamination, the ends of tubes by two cooperating connecting components, each having an inlet and an outlet for connection to each other. The connecting components each have a connecting plane, into which the outlets open, each covered by a protective component, and which are movable into engagement with each other with the outlets facing each other. A locking element, which is slidably arranged on one connecting component, is, in a controlled manner and without interruption of the sliding movement, movable onto the other connecting component to a distinct end position. The protective components are removable by means of the locking element when this is moved, and the outlets are sealingly pressable against each other. The locking element is prevented from moving until a predetermined force is applied in the moving direction.

Abstract: A syringe for a fluid comprises a cylinder, a piston portion arranged in the cylinder and slidable on its inside, and an operating means connected to the piston portion for sliding thereof. The operating means projects from a first end of the cylinder and the cylinder has at a second end an inlet and outlet part for said fluid. Moreover a sealing means is connected in a contamination-free manner to the cylinder in the area of the first end thereof and extends into the cylinder to isolate, sealed against contamination, the inside of the cylinder from the environment.

Abstract: The present invention relates to a device for treatment of material in a vessel, particularly for dispersion or homogenization of liquids, or for suspension of solids in liquids. The device comprises a treatment element that is rotationally mounted in the vessel and that has an essentially tubular configuration comprising two ends. The jacket of the treatment element has a plurality of cuts formed with sharp edges, which may be drawn through the material in the vessel as the treatment element rotates, in order to transfer shearing forces to said material. The shearing forces produce the desired treatment in the vessel.