Patents by Inventor H. Kim Lyerly

H. Kim Lyerly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Smoothened modulators and methods of use thereof
    Patent number: 9512106
    Abstract: Compounds of general Formulas (I), (IA), (IB) are described, along with compositions containing the same and methods of use thereof, inhibiting the hedgehog pathway in a cell or inhibiting unwanted proliferation of a cell.
    Type: Grant
    Filed: September 16, 2013
    Date of Patent: December 6, 2016
    Assignee: Duke University
    Inventors: Wei Chen, Jiangbo Wang, Robert A. Mook, Jr., Lawrence S. Barak, H. Kim Lyerly, Anthony Angelo Ribeiro
  • SMOOTHENED MODULATORS AND METHODS OF USE THEREOF
    Publication number: 20150166509
    Abstract: Compounds of general Formulas (I), (IA), (IB) are described, along with compositions containing the same and methods of use thereof, inhibiting the hedgehog pathway in a cell or inhibiting unwanted proliferation of a cell.
    Type: Application
    Filed: September 16, 2013
    Publication date: June 18, 2015
    Inventors: Wei Chen, Jiangbo Wang, Robert A. Mook, JR., Lawrence S. Barak, H. Kim Lyerly, Anthony Angelo Ribeiro
  • TREATMENT OF WNT/FRIZZLED-RELATED DISEASES
    Publication number: 20130005802
    Abstract: Methods of treating Wnt/Frizzled-related diseases, comprising administering niclosamide compounds are provided. Methods of predicting whether a disease will respond to treatment with a niclosamide compound are also provided.
    Type: Application
    Filed: September 21, 2010
    Publication date: January 3, 2013
    Inventors: Wei Chen, Minyong Chen, H. Kim Lyerly, Lawrence S. Barak, Robert Mook, Takuya Osada, Michael A. Morse
  • SMOOTHENED RECEPTOR MODULATORS
    Publication number: 20120094974
    Abstract: The present invention relates, in general, to the Smoothened receptor and, in particular, to a method of modulating Smoothened receptor activity and to compounds and compositions suitable for use in such a method.
    Type: Application
    Filed: June 16, 2009
    Publication date: April 19, 2012
    Inventors: Wei Chen, Lawrence Barak, H. Kim Lyerly, Jiangbo Wang