Patents by Inventor H. Robert Masure
H. Robert Masure has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7479282Abstract: This invention provides an isolated polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate in which the amino acid sequence is set forth in any of SEQ ID NOS: 1, 3-7, or 9-11, including fragments, mutants, variants, analogs, or derivatives, thereof. Also, this invention provides a isolated polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate, wherein the amino acid is set forth in SEQ ID NO: 24, wherein the polypeptide retains its native tertiary structure and methods of preparation. This invention provides an isolated polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate, wherein the polypeptide has lectin activity and does not bind to choline. This invention provides an isolated immunogenic polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate.Type: GrantFiled: January 5, 2004Date of Patent: January 20, 2009Assignees: St. Jude Children's Research Hospital, MedimmuneInventors: Elaine I. Tuomanen, Theresa M. Wizemann, H. Robert Masure, Leslie S. Johnson, Scott Koenig
-
Patent number: 7425327Abstract: The invention relates to bacterial choline binding proteins (CBPs) which bind choline. Such proteins are particularly desirable for vaccines against appropriate strains of Gram positive bacteria, particularly streptococcus, and more particularly pneumococcus. Also provided are DNA sequences encoding the bacterial choline binding proteins or fragment thereof, antibodies to the bacterial choline binding proteins, pharmaceutical compositions comprising the bacterial choline binding proteins, antibodies to the bacterial choline binding proteins suitable for use in passive immunization, and small molecule inhibitors of choline binding protein mediated adhesion. Methods for diagnosing the presence of the bacterial choline binding protein, or of the bacteria, are also provided. In a specific embodiment, a streptococcal choline binding protein is an enolase, which demonstrates strong affinity for fibronectin.Type: GrantFiled: July 28, 2004Date of Patent: September 16, 2008Assignee: The Rockefeller UniversityInventors: H. Robert Masure, Carsten I. Rosenow, Elaine Tuomanen, Theresa M. Wizemann
-
Patent number: 6858706Abstract: This invention provides an isolated polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate in which the amino acid sequence is set forth in any of SEQ ID NOS: 1, 3-7, or 9-11, including fragments, mutants, variants, analogs, or derivatives, thereof. Also, this invention provides a isolated polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate, wherein the amino acid is set forth in SEQ ID NO 24, wherein the polypeptide retains its native tertiary structure and methods of preparation. This invention provides an isolated polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate, wherein the polypeptide has lectin activity and does not bind to choline. This invention provides an isolated immunogenic polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate.Type: GrantFiled: April 7, 1998Date of Patent: February 22, 2005Assignees: St. Jude Children's Research Hospital, MedImmune, Inc.Inventors: Elaine I. Tuomanen, Theresa M. Wizemann, H. Robert Masure, Leslie Sydnor Johnson, Scott Koenig
-
Patent number: 6784164Abstract: The invention relates to bacterial choline binding proteins (CBPs) which bind choline. Such proteins are particularly desirable for vaccines against appropriate strains of Gram positive bacteria, particularly streptococcus, and more particularly pneumococcus. Also provided are DNA sequences encoding the bacterial choline binding proteins or fragment thereof, antibodies to the bacterial choline binding proteins, pharmaceutical compositions comprising the bacterial choline binding proteins, antibodies to the bacterial choline binding proteins suitable for use in passive immunization, and small molecule inhibitors of choline binding protein mediated adhesion. Methods for diagnosing the presence of the bacterial choline binding protein, or of the bacteria, are also provided. In a specific embodiment, a streptococcal choline binding protein is an enolase, which demonstrates strong affinity for fibronectin.Type: GrantFiled: April 9, 2001Date of Patent: August 31, 2004Assignee: The Rockefeller UniversityInventors: H. Robert Masure, Carsten I. Rosenow, Elaine Tuomanen, Theresa M. Wizemann
-
Publication number: 20040120966Abstract: This invention provides an isolated polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate in which the amino acid sequence is set forth in any of SEQ ID NOS: 1, 3-7, or 9-11, including fragments, mutants, variants, analogs, or derivatives, thereof. Also, this invention provides a isolated polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate, wherein the amino acid is set forth in SEQ ID NO: 24, wherein the polypeptide retains its native tertiary structure and methods of preparation. This invention provides an isolated polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate, wherein the polypeptide has lectin activity and does not bind to choline. This invention provides an isolated immunogenic polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate.Type: ApplicationFiled: January 5, 2004Publication date: June 24, 2004Applicants: St. Jude Children's Research Hospital, Medimmune, Inc.Inventors: Elaine I. Tuomanen, Theresa M. Wizemann, H. Robert Masure, Leslie Sydnor Johnson, Scott Koenig
-
Publication number: 20030175293Abstract: The invention relates to bacterial choline binding proteins (CBPs) which bind choline. Such proteins are particularly desirable for vaccines against appropriate strains of Gram positive bacteria, particularly streptococcus, and more particularly pneumococcus. Also provided are DNA sequences encoding the bacterial choline binding proteins or fragment thereof, antibodies to the bacterial choline binding proteins, pharmaceutical compositions comprising the bacterial choline binding proteins, antibodies to the bacterial choline binding proteins suitable for use in passive immunization, and small molecule inhibitors of choline binding protein mediated adhesion. Methods for diagnosing the presence of the bacterial choline binding protein, or of the bacteria, are also provided. In a specific embodiment, a streptococcal choline binding protein is an enolase, which demonstrates strong affinity for fibronectin.Type: ApplicationFiled: April 9, 2001Publication date: September 18, 2003Inventors: H. Robert Masure, Carsten I. Rosenow, Elaine Tuomanen, Theresa M. Wizemann
-
Publication number: 20030096950Abstract: This invention provides an isolated polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate in which the amino acid sequence is set forth in any of SEQ ID NOS: 1, 3-7, or 9-11, including fragments, mutants, variants, analogs, or derivatives, thereof.Type: ApplicationFiled: April 7, 1998Publication date: May 22, 2003Inventors: ELAINE I. TUOMANEN, THERESA M WIZEMANN, H. ROBERT MASURE, LESLIE SYDNOR JOHNSON, SCOTT KOENIG
-
Patent number: 6245335Abstract: The invention relates to bacterial choline binding proteins (CBPs) which bind choline. Such proteins are particularly desirable for vaccines against appropriate strains of Gram positive bacteria, particularly streptococcus, and more particularly pneumococcus. Also provided are DNA sequences encoding the bacterial choline binding proteins or fragment thereof, antibodies to the bacterial choline binding proteins, pharmaceutical compositions comprising the bacterial choline binding proteins, antibodies to the bacterial choline binding proteins suitable for use in passive immunization, and small molecule inhibitors of choline binding protein mediated adhesion. Methods for diagnosing the presence of the bacterial choline binding protein, or of the bacteria, are also provided. In a specific embodiment, a streptococcal choline binding protein is an enolase, which demonstrates strong affinity for fibronectin.Type: GrantFiled: May 1, 1997Date of Patent: June 12, 2001Assignee: The Rockefeller UniversityInventors: H. Robert Masure, Carsten I. Rosenow, Elaine Tuomanen, Theresa M. Wizemann
-
Patent number: 6015560Abstract: Peptides which will inhibit the reaction between the RGD tripeptide of FHA and the integrin receptors of endothelial cells and their utility as therapeutic agents are described.Type: GrantFiled: June 6, 1995Date of Patent: January 18, 2000Assignee: The Rockfeller UniversityInventors: Elaine Tuomanen, H. Robert Masure
-
Patent number: 5981229Abstract: Provided herein are novel nucleic acids which encode exported proteins of Gram positive bacteria, and the proteins encoded by such nucleic acids. Also provided are methods of producing such exported proteins, and vaccines for protecting an animal from infection with a gram positive bacterium, wherein the vaccines utilize the novel nucleic acids and proteins of the invention.Type: GrantFiled: April 10, 1996Date of Patent: November 9, 1999Assignee: The Rockefeller UniversityInventors: H. Robert Masure, Barbara J. Pearce, Elaine Tuomanen
-
Patent number: 5968512Abstract: Peptides which will inhibit the reaction between the RGD tripeptide of FHA and the integrin receptors of endothelial cells and their utility as therapeutic agents are described.Type: GrantFiled: June 6, 1995Date of Patent: October 19, 1999Assignee: The Rockefeller UniversityInventors: Elaine Tuomanen, H. Robert Masure
-
Patent number: 5932217Abstract: Peptides which will inhibit the reaction between the RGD tripeptide of FHA and the integrin receptors of endothelial cells and their utility as therapeutic agents are described.Type: GrantFiled: November 30, 1994Date of Patent: August 3, 1999Assignee: The Rockefeller UniversityInventors: Elaine Tuomanen, H. Robert Masure
-
Patent number: 5928900Abstract: The present invention relates to the identification of Gram positive bacterial exported proteins, and the genes encoding such proteins. In particular, the invention relates to adhesion associated exported proteins, and to antigens common to many or all strains of a species of Gram positive bacterium. The invention also relates to acellular vaccines to provide protection from Gram positive bacterial infection using such genes or such proteins, and to antibodies against such proteins for use in diagnosis and passive immune therapy. In specific embodiments, fragments of ten genes encoding exported proteins of S. pneumoniae are disclosed, and the functional activity of some of these proteins in adherence is demonstrated.Type: GrantFiled: May 18, 1994Date of Patent: July 27, 1999Assignee: The Rockefeller UniversityInventors: H. Robert Masure, Barbara J. Pearce, Elaine Tuomanen
-
Patent number: 5834278Abstract: The present invention relates to the identification of a bacterial adhesion associated protein, and the gene encoding such protein. More particularly, the invention relates to a pneumococcal peptide methionine sulfoxide reductase involved in bacterial adherence. The invention also relates to identification and development of agents to provide protection from bacterial infection based on this protein.The invention provides nucleic acids encoding the peptide methionine sulfoxide reductase, as well as methods for identifying antagonists of the methionine sulfoxide reductase. The present invention further demonstrates that peptide methionine sulfoxide reductase is an adhesion-associated protein in various Gram-negative and Gram-positive bacteria and accordingly provides for interference with the peptide methionine sulfoxide reductase to inhibit bacterial adherence to host tissues.Type: GrantFiled: May 1, 1996Date of Patent: November 10, 1998Assignee: The Rockefeller UniversityInventors: Elaine Tuomanen, H. Robert Masure, Theresa M. Wizemann
-
Patent number: 5817617Abstract: Proteins, peptides, analogs thereof and antibodies thereto which will inhibit the adhesion of circulating molecules such as leukocytes to endothelia and epithelia.Type: GrantFiled: May 27, 1994Date of Patent: October 6, 1998Assignee: The Rockefeller UniversityInventors: Elaine Tuomanen, H. Robert Masure
-
Patent number: 5798243Abstract: The present invention relates to the identification of a bacterial adhesion associated protein, and the gene encoding such protein. More particularly, the invention relates to a pneumococcal peptide methionine sulfoxide reductase involved in bacterial adherence. The invention also relates to identification and development of agents to provide protection from bacterial infection based on this protein. The invention provides nucleic acids encoding the peptide methionine sulfoxide reductase, as well as methods for identifying antagonists of the methionine sulfoxide reductase. The present invention further demonstrates that peptide methionine sulfoxide reductase is an adhesion-associated protein in various Gram-negative and Gram-positive bacteria and accordingly provides for interference with the peptide methionine sulfoxide reductase to inhibit bacterial adherence to host tissues.Type: GrantFiled: August 20, 1997Date of Patent: August 25, 1998Assignee: The Rockefeller UniversityInventors: Elaine Tuomanen, H. Robert Masure, Theresa M. Wizemann
-
Patent number: 5792457Abstract: Peptides and antibodies which will inhibit the reaction between the RGD tripeptide of FHA and the integrin receptors of endothelial cells and their utility as therapeutic agents and a method of increasing the permeability of the blood-brain barrier using an antibody to the Arg-Gly-Asp (RGD) region of filamentous hemagglutinin (FHA) are described.Type: GrantFiled: June 6, 1995Date of Patent: August 11, 1998Assignee: The Rockefeller UniversityInventors: Elaine Tuomanen, H. Robert Masure