Abstract: A process of the operation of simulated moving bed is disclosed in which said bed is packed with a solid sorbent and provided with a plurality of pipes acting as a feed stock inlet, a desorbent inlet, a sorbed component outlet and a non-sorbed component outlet and the upstream end and the downstream end of the bed are interconnected to form a loop path, and a fluid containing the sorbed component and the non-sorbed component, and a desorbent are supplied to the bed and the sorbed component and the non-sorbed component separated are recovered. An improvement comprises the flow rate of the fluid is controlled on the basis of the concentration distribution of the sorbed and the non-sorbed components whereby the separated components are recovered in high purity and in constant composition.

Abstract: There is disclosed a process for isomerization of glucose into fructose which comprises contacting an aqueous glucose solution with glucose isomerase in the presence of iron ion and magnesium ion, said glucose isomerase being in the form of insolubilized glucose isomerase adsorbed on a carrier.