Patents by Inventor Hae-Young Koh

Hae-Young Koh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phospholipase C ?1 (PLC?1) knockout mice as a model system for testing schizophrenia drugs
    Patent number: 7521590
    Abstract: The present invention relates to a method for screening therapeutic drugs of schizophrenia using an animal model of the disease. More specifically, this invention relates to a screening method based on the phospholipase C ?1 (PLC?1) knockout mouse as an animal model of schizophrenia with all the major symptoms of the human disease. This knockout mouse exhibits symptoms similar to human schizophrenia such as locomotor hyperactivity, impaired prepulse inhibition of the startle response, lack of barbering and nesting behaviors, socially subordinate status, impaired learning, and lack of type II theta rhythm which has been implicated in working memory. Thus, the knockout mouse of the present invention can be useful as an animal for screening therapeutic drugs against schizophrenia.
    Type: Grant
    Filed: April 26, 2007
    Date of Patent: April 21, 2009
    Assignee: Korea Institute of Science and Technology
    Inventors: Heesup Shin, Hae-Young Koh, Daesoo Kim, Sukchan Lee
  • PHOSPHOLIPASE C BETA1 (PLCBETA1) KNOCKOUT MICE AS A MODEL SYSTEM FOR TESTING SCHIZOPHRENIA DRUGS
    Publication number: 20080060088
    Abstract: The present invention relates to a method for screening therapeutic drugs of schizophrenia using an animal model of the disease. More specifically, this invention relates to a screening method based on the phospholipase C ?1 (PLC?1) knockout mouse as an animal model of schizophrenia with all the major symptoms of the human disease. This knockout mouse exhibits symptoms similar to human schizophrenia such as locomotor hyperactivity, impaired prepulse inhibition of the startle response, lack of barbering and nesting behaviors, socially subordinate status, impaired learning, and lack of type II theta rhythm which has been implicated in working memory. Thus, the knockout mouse of the present invention can be useful as an animal for screening therapeutic drugs against schizophrenia.
    Type: Application
    Filed: April 26, 2007
    Publication date: March 6, 2008
    Inventors: Heesup Shin, Hae-Young Koh, Daesoo Kim, Sukchan Lee