Patents by Inventor Hagi Alon

Hagi Alon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solid state forms of linaclotide
    Patent number: 10889620
    Abstract: Solid state forms of Linaclotide, processes for their preparation, compositions comprising them and medical uses thereof are provided. The solid state forms of Linaclotide are useful in the preparation of other solid state forms of Linaclotide, particularly the amorphous form.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: January 12, 2021
    Assignee: NOVETIDE LTD.
    Inventors: Chaim Eidelman, Hagi Alon, Dov Vayer, Sharon Penias-Navon, Jonathan Enav
  • SOLID STATE FORMS OF LINACLOTIDE
    Publication number: 20190194256
    Abstract: Solid state forms of Linaclotide, processes for their preparation, compositions comprising them and medical uses thereof are provided. The solid state forms of Linaclotide are useful in the preparation of other solid state forms of Linaclotide, particularly the amorphous form.
    Type: Application
    Filed: July 1, 2016
    Publication date: June 27, 2019
    Inventors: Chaim EIDELMAN, Hagi ALON, Dov VAYER, Sharon PENIAS-NAVON, Jonathan ENAV
  • PRODUCTION OF PEPTIDES CONTAINING POLY-GLY SEQUENCES USING FMOC CHEMISTRY
    Publication number: 20110160431
    Abstract: A peptide containing a poly-Gly sequence, such as bivalirudin, can be prepared in a purified form in which low amounts of GIy deletion or GIy addition byproducts are present. A protected poly-Gly-containing peptide is attached to a resin using Fmoc-Gly-GIy-OH units for assembly of the poly-Gly segment. The protected peptide is then cleaved from the resin with an acidic composition to produce an unprotected or semi-protected crude peptide, which can then be isolated from acidic composition.
    Type: Application
    Filed: March 29, 2010
    Publication date: June 30, 2011
    Applicant: NOVETIDE, LTD.
    Inventors: Avi Tovi, Chaim Eidelman, Shimon Shushan, Hagi Alon, Alexander Ivchenko, Leah Bar-0z
  • PROCESS FOR PRODUCTION OF CYCLIC PEPTIDES
    Publication number: 20100240865
    Abstract: The invention relates to methods for the preparation of polypeptides. The polypeptides are prepared in high purity of at least about 98.5%, and preferably at least about 99% by HPLC.
    Type: Application
    Filed: February 4, 2010
    Publication date: September 23, 2010
    Inventors: Avi Tovi, Chaim Eidelman, Shimon Shushan, Shai Elster, Hagi Alon
  • PROCESS FOR PRODUCTION OF CYCLIC PEPTIDES
    Publication number: 20100137559
    Abstract: The invention relates to methods for the preparation of polypeptides. The polypeptides are prepared in high purity of at least about 98.5%, and preferably at least about 99% by HPLC.
    Type: Application
    Filed: February 4, 2010
    Publication date: June 3, 2010
    Inventors: Avi TOVI, Chaim Eidelman, Shimon Shushan, Shai Elster, Hagi Alon
  • Caspofungin free of caspofungin impurity A
    Publication number: 20090324635
    Abstract: Provided is caspofungin free of caspofungin impurity A, methods for preparation thereof and isolation of caspofungin impurity A.
    Type: Application
    Filed: June 25, 2009
    Publication date: December 31, 2009
    Inventors: Ferenc Korodi, Piroska Kovacs, Chaim Eidelman, Avi Tovi, Hagi Alon
  • Methods for the production of peptide derivatives
    Publication number: 20060276626
    Abstract: The invention relates to methods for the preparation of peptides which are a C-terminal amide derivatives by a combination of solid-phase synthesis and post assembly solution phase synthesis. The peptides which are a C-terminal amide derivatives are further converted to peptide acetates. The invention also relates to pure peptide acetates and to protected peptide precursors.
    Type: Application
    Filed: May 2, 2006
    Publication date: December 7, 2006
    Inventors: Avi Tovi, Chaim Eidelman, Shimon Shushan, Shai Elster, Hagi Alon, Alexander Ivchenko, Gabriel-Marcus Butilca, Gil Zaovi, Eleonora Alterman, Leah Bar-Oz, Tehila Gadi
  • Counterion exchange process for peptides
    Publication number: 20060148699
    Abstract: The invention encompasses a process for purifying a peptide comprising loading a peptide onto a RP-HPLC column; washing the column with an aqueous solution of a pharmaceutically acceptable counterion salt; and eluting the peptide from the column with a solvent mixture of a organic solvent and an acid of the pharmaceutically acceptable counterion, wherein the aqueous solution has a pH of at least about 6.
    Type: Application
    Filed: October 4, 2005
    Publication date: July 6, 2006
    Inventors: Avi Tovi, Chaim Eidelman, Shimon Shushan, Shai Elster, Hagi Alon, Alexander Ivchenko, Gabriel-Marcus Butilca, Gil Zaovi
  • Process for production of cyclic peptides
    Publication number: 20040249121
    Abstract: The invention relates to methods for the preparation of polypeptides. The polypeptides are prepared in high purity of at least about 98.5%, and preferably at least about 99% by HPLC.
    Type: Application
    Filed: April 5, 2004
    Publication date: December 9, 2004
    Inventors: Avi Tovi, Chaim Eidelman, Shimon Shushan, Shai Elster, Hagi Alon