Patents by Inventor Hagopian Arpi

Hagopian Arpi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vaccines comprising yeast-derived hepatits B virus polypeptides
    Patent number: 5133961
    Abstract: The entire hepatitis B virus pre-S antigen gene linked in one contiguous reading frame to the hepatitus B virus surface antigen gene has been expressed in Saccharomyces cerevisiae. The expressed protein aggregates into a particulate form which displays the major antigenic sites encoded by both domains, thereby highlighting the utility of yeast as a host for the expression of pre-S domains. This protein is useful in in vitro diagnostic systems and as a vaccine for the treatment and prevention of hepatitis B virus-induced diseases and/or infections.
    Type: Grant
    Filed: June 29, 1987
    Date of Patent: July 28, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Ronald W. Ellis, Peter J. Kniskern, Hagopian Arpi