Abstract: Methods of depositing nanoparticles onto a substrate (e.g., an implant) are provided, as are the resulting substrates (e.g., implants) formed by such deposition methods. The nanoparticles can be silver nanoparticles that provide antimicrobial or antibacterial properties to the substrate.

Abstract: A monolithic dental implant formed from an additive manufacturing method can include a non-porous portion and a porous structure. The porous structure can increase osseointegration of the dental implant and increase the secondary stability.

Abstract: Methods of depositing nanoparticles onto a substrate (e.g., an implant) are provided, as are the resulting substrates (e.g., implants) formed by such deposition methods. The nanoparticles can be silver nanoparticles that provide antimicrobial or antibacterial properties to the substrate.

Abstract: A method for securing a dental implant within a dental bone cavity is disclosed. The method may include inserting a dental wedge into the dental bone cavity and allowing bone tissues to grow toward and at least partially surround the dental wedge. Dental implantation systems for implementing the method are also disclosed. The system can include a dental wedge adapted to be inserted into a dental bone cavity.

Abstract: Dental compositions are disclosed. A dental composition can include a reaction produce of a reaction mixture comprising a first mixture and a second mixture. The first mixture can include a ceramic based biomaterial, and the second mixture can include mineral trioxide aggregate and a phosphoric acid monomer.

Abstract: A method for securing a dental implant within a dental bone cavity is disclosed. The method may include inserting a dental wedge into the dental bone cavity and allowing bone tissues to grow toward and at least partially surround the dental wedge. Dental implantation systems for implementing the method are also disclosed. The system can comprise a dental wedge adapted to be inserted into a dental bone cavity.

Abstract: A method for securing a dental implant within a dental bone cavity is disclosed. The method may include inserting a dental wedge into the dental bone cavity and allowing bone tissues to grow toward and at least partially surround the dental wedge. Dental implantation systems for implementing the method are also disclosed. The system can include a dental wedge adapted to be inserted into a dental bone cavity.

Abstract: Dental compositions are disclosed. A dental composition can include a reaction produce of a reaction mixture comprising a first mixture and a second mixture. The first mixture can include a ceramic based biomaterial, and the second mixture can include mineral trioxide aggregate and a phosphoric acid monomer.

Abstract: A bone void filler composition is described containing an acidic mineral component that contains a calcium source and a phosphate source or a lower alkyl carboxylate source; an osteoinductive component that contains demineralized bone; and a three-dimensional, osteoconductive biologically acceptable carrier component that contains a collagenous material. The bone void filler composition may be in the form of a sponge or in the form of a paste or putty used to form a sponge or is obtained from particulated sponge, or that forms after a sponge is rehydrated. A pre-mixed bone void filler composition is described containing the acidic mineral component or the lower alkyl carboxylate source; the osteoinductive component; and a biologically acceptable carrier component that contains a liquid carrier. Methods of making and using the compositions are also described. The ratio of demineralized bone component to acidic mineral component may range from about 0.5:1 to about 80:1.

Abstract: A method for securing a dental implant within a dental bone cavity is disclosed. The method may include inserting a dental wedge into the dental bone cavity and allowing bone tissues to grow toward and at least partially surround the dental wedge. Dental implantation systems for implementing the method are also disclosed. The system can comprise a dental wedge adapted to be inserted into a dental bone cavity.

Abstract: The invention provides novel dental enamel inspired materials for biomedical and dental applications. The materials are apatite-like calcium phosphate complexes and may comprise apatite, octacalcium phosphate crystals, or mixtures thereof. In one embodiment, the materials (calcium phosphate coatings) are mixtures of crystals of apatite and its precursor, octacalcium phosphate, nucleated on a titanium surface. They are prepared using a chemical process leading to the formation of biological apatite which is similar to that found in natural bone and teeth. In one embodiment, the materials are prepared by placing a titanium substrate in a supersaturated calcifying solution containing native or purified recombinant amelogenins. The presence of the amelogenins modulates apatite crystal growth to mimic in vivo apatite crystal formation.

Abstract: A bone void filler composition is described containing an acidic mineral component that contains a calcium source and a phosphate source or a lower alkyl carboxylate source; an osteoinductive component that contains demineralized bone; and a three-dimensional, osteoconductive biologically acceptable carrier component that contains a collagenous material. The bone void filler composition may be in the form of a sponge or in the form of a paste or putty used to form a sponge or is obtained from particulated sponge, or that forms after a sponge is rehydrated. A pre-mixed bone void filler composition is described containing the acidic mineral component or the lower alkyl carboxylate source; the osteoinductive component; and a biologically acceptable carrier component that contains a liquid carrier. Methods of making and using the compositions are also described. The ratio of demineralized bone component to acidic mineral component may range from about 0.5:1 to about 80:1.

Abstract: An apparatus for producing a biomimetic coating on an implantable article is provided. The apparatus includes an outer reactor for containing a biomimetic coating solution and an inner reactor arranged within the outer reactor. The inner reactor is smaller than the outer reactor so as to define a space between the inner and outer reactors. The apparatus also includes a pump system for circulating the biomimetic coating solution. The pump system is arranged to operate in the space between the inner and outer reactors. The inner reactor includes a flow control system that is selectively operable to control the flow of biomimetic coating solution between the outer and inner reactors.

Abstract: The invention provides a method of providing a metallic orthopaedic implant with a micron or nanometer-scale surface roughness to facilitate acceptance of tissue and bone growth or apposition after implantation while maintaining the structural integrity of the orthopaedic implant. The invention also provides a metallic orthopaedic implant comprising a metallic body and metallic elements adhered to a portion of the surface of the metallic body to define a three-dimensional porous surface geometry, wherein at least some of the metallic elements have a micron or nanometer-scale surface roughness.

Abstract: The invention provides novel dental enamel inspired materials for biomedical and dental applications. The materials are apatite-like calcium phosphate complexes and may comprise apatite, octacalcium phosphate crystals, or mixtures thereof. In one embodiment, the materials (calcium phosphate coatings) are mixtures of crystals of apatite and its precursor, octacalcium phosphate, nucleated on a titanium surface. They are prepared using a chemical process leading to the formation of biological apatite which is similar to that found in natural bone and teeth. In one embodiment, the materials are prepared by placing a titanium substrate in a supersaturated calcifying solution containing native or purified recombinant amelogenins. The presence of the amelogenins modulates apatite crystal growth to mimic in vivo apatite crystal formation.

Abstract: The invention provides an implantable article, a method of preparing the same, and methods of modifying a ceramic-coated implantable article. The implantable article comprises a biocompatible substrate and a bioactive ceramic surface coating into which a biological agent is incorporated. The preparation and modification of an implantable article involve incubating a biocompatible substrate surface or pre-existing ceramic coating thereon with a composition comprising (i) a biological agent, (ii) calcium ions, (iii) phosphate ions, and (iv) a liquid carrier.

Abstract: The invention provides a method of providing a metallic orthopaedic implant with a micron or nanometer-scale surface roughness to facilitate acceptance of tissue and bone growth or apposition after implantation while maintaining the structural integrity of the orthopaedic implant. The invention also provides a metallic orthopaedic implant comprising a metallic body and metallic elements adhered to a portion of the surface of the metallic body to define a three-dimensional porous surface geometry, wherein at least some of the metallic elements have a micron or nanometer-scale surface roughness.

Abstract: The invention provides a method of providing a metallic orthopaedic implant with a micron or nanometer-scale surface roughness to facilitate acceptance of tissue and bone growth or apposition after implantation while maintaining the structural integrity of the orthopaedic implant. The invention also provides a metallic orthopaedic implant comprising a metallic body and metallic elements adhered to a portion of the surface of the metallic body to define a three-dimensional porous surface geometry, wherein at least some of the metallic elements have a micron or nanometer-scale surface roughness.

Abstract: The invention provides an implantable article, a method of preparing the same, and methods of modifying a ceramic-coated implantable article. The implantable article comprises a biocompatible substrate and a bioactive ceramic surface coating into which a biological agent is incorporated. The preparation and modification of an implantable article involve incubating a biocompatible substrate surface or pre-existing ceramic coating thereon with a composition comprising (i) a biological agent, (ii) calcium ions, (iii) phosphate ions, and (iv) a liquid carrier.

Abstract: The invention provides novel dental enamel inspired materials for biomedical and dental applications. The materials are apatite-like calcium phosphate complexes and may comprise apatite, octacalcium phosphate crystals, or mixtures thereof. In one embodiment, the materials (calcium phosphate coatings) are mixtures of crystals of apatite and its precursor, octacalcium phosphate, nucleated on a titanium surface. They are prepared using a chemical process leading to the formation of biological apatite which is similar to that found in natural bone and teeth. In one embodiment, the materials are prepared by placing a titanium substrate in a supersaturated calcifying solution containing native or purified recombinant amelogenins. The presence of the amelogenins modulates apatite crystal growth to mimic in vivo apatite crystal formation.