Patents by Inventor Haiyin Chen

Haiyin Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Miniaturized, automated in-vitro tissue bioreactor
    Patent number: 10793820
    Abstract: In one embodiment, a system includes a bioreactor coupled to a substrate. The bioreactor includes: a plurality of walls defining a reservoir; a plurality of fluidic channels in at least some of the walls; a fluidic inlet in fluidic communication with the reservoir via, the fluidic channels; a fluidic outlet in fluidic communication with the reservoir via the fluidic channels; and one or more sensors coupled to the reservoir, each sensor being configured to detect one or more of: environmental conditions in the reservoir; and physiological conditions of one or more cells optionally present in the reservoir. In another embodiment, a method includes delivering media to a reservoir of a bioreactor; delivering a plurality of cells to the reservoir, controlling a reservoir temperature and a reservoir gas composition; using one or more of the sensors to monitor environmental and physiological conditions; and reporting the environmental and/or physiological conditions.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: October 6, 2020
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Heeral Sheth, Haiyin Chen, Bryan D. Hudson, Kris Kulp, Margaret W. Mcnerney, Satinderpall S. Pannu, Fang Qian, Angela C. Tooker, Elizabeth K. Wheeler, Vanessa Tolosa
  • MINIATURIZED, AUTOMATED IN-VITRO TISSUE BIOREACTOR
    Publication number: 20140322701
    Abstract: In one embodiment, a system includes a bioreactor coupled to a substrate. The bioreactor includes: a plurality of walls defining a reservoir; a plurality of fluidic channels in at least some of the walls; a fluidic inlet in fluidic communication with the reservoir via, the fluidic channels; a fluidic outlet in fluidic communication with the reservoir via the fluidic channels; and one or more sensors coupled to the reservoir, each sensor being configured to detect one or more of: environmental conditions in the reservoir; and physiological conditions of one or more cells optionally present in the reservoir. In another embodiment, a method includes delivering media to a reservoir of a bioreactor; delivering a, plurality of cells to the reservoir, controlling a reservoir temperature and a reservoir gas composition; using one or more of the sensors to monitor environmental and physiological conditions; and reporting the environmental and/or physiological conditions.
    Type: Application
    Filed: April 29, 2014
    Publication date: October 30, 2014
    Applicant: Lawrence Livermore National Security, LLC
    Inventors: Heeral Sheth, Haiyin Chen, Bryan D. Hudson, Kris Kulp, Margaret W. Mcnerney, Satinderpall S. Pannu, Fang Qian, Angela C. Tooker, Elizabeth K. Wheeler