Patents by Inventor Haibo Lai

Haibo Lai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240115541
    Abstract: The invention provides a method for treating cerebral apoplexy and hyperbilirubinemia by the compound or reagent for competitively inhibiting or blocking combination of bilirubin and the TRPM2 channel. The compound or the reagent is competitively combined with the D1069 residue of TRPM2 channel (the analogous D1066 residue of the mouse TRPM2). It is verified that bilirubin can serve as an extracellular endogenous agonist to be directly combined with the TRPM2 channel to aggravate brain tissue damage caused by stroke and hyperbilirubinemia, K928 and/or D1069 residues are key amino acid residues for playing roles. When the K928 and/or D1069 residues are mutated or competitively combined, the bilirubin is prevented from activating the TRPM2 channel; wherein D1069 residue mutation can effectively antagonize the nerve injury effect caused by bilirubin, which would be a therapeutic target for relieving and treating ischemic stroke and hyperbilirubinemia related brain damage.
    Type: Application
    Filed: March 28, 2023
    Publication date: April 11, 2024
    Inventors: Shankai YIN, Haibo SHI, Hanwei LIU, Ke LAI, Luyang WANG
  • Patent number: D915404
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: April 6, 2021
    Inventor: Haibo Lai
  • Patent number: D925141
    Type: Grant
    Filed: January 12, 2021
    Date of Patent: July 13, 2021
    Assignee: SHENZHEN XINCHI NETWORK & TECH CO., LTD.
    Inventor: Haibo Lai
  • Patent number: D939135
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: December 21, 2021
    Assignee: SHENZHEN XINCHI NETWORK & TECH CO., LTD.
    Inventor: Haibo Lai
  • Patent number: D941034
    Type: Grant
    Filed: April 12, 2021
    Date of Patent: January 18, 2022
    Inventor: Haibo Lai
  • Patent number: D946806
    Type: Grant
    Filed: April 25, 2021
    Date of Patent: March 22, 2022
    Assignee: SHENZHEN XINCHI NETWORK & TECH CO., LTD.
    Inventor: Haibo Lai
  • Patent number: D958431
    Type: Grant
    Filed: May 26, 2021
    Date of Patent: July 19, 2022
    Assignee: SHENZHEN XINCHI NETWORK & TECH CO., LTD.
    Inventor: Haibo Lai