Abstract: Provided is a method for locating an epilepsy seizure onset zone and prediction of seizure outcome including receiving interictal electroencephalographs from two or more points in a patient's cerebral cortex. The interictal electroencephalographs are used to determine directional information flow values which indicate dominant information flow from a non-seizure zone to a seizure onset zone. The directional informational flow values may be input into a classification model trained to predict whether the two or more points in the patient's cerebral cortex are a seizure onset zone and/or classify the patient's predicted post-treatment seizure outcome after epilepsy treatment based on the directional information flow values. An output from the classification model may indicate a location of seizure onset zone in the patient's cerebral cortex and/or the patient's predicted post-treatment seizure outcome after epilepsy treatment. Systems and computer program products are also provided.