Patents by Inventor Hai-Xiao Zhai

Hai-Xiao Zhai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • YAP1 inhibitors and methods
    Patent number: 11331304
    Abstract: YAP1 inhibitors and methods of treating a subject with a cancer that include administering a YAP1 inhibitor are disclosed. Also disclosed are methods for determining responsiveness to a YAP1 inhibitor in a subject, methods for diagnosing a tumor in a subject including determining the level of YAP1 expression, compositions that include YAP1 inhibitors, and methods of using those compositions.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: May 17, 2022
    Assignee: The Jackson Laboratory
    Inventors: Kyuson Yun, Hai-Xiao Zhai
  • YAP1 INHIBITORS AND METHODS
    Publication number: 20190298693
    Abstract: YAP1 inhibitors and methods of treating a subject with a cancer that include administering a YAP1 inhibitor are disclosed. Also disclosed are methods for determining responsiveness to a YAP1 inhibitor in a subject, methods for diagnosing a tumor in a subject including determining the level of YAP1 expression, compositions that include YAP1 inhibitors, and methods of using those compositions.
    Type: Application
    Filed: May 11, 2017
    Publication date: October 3, 2019
    Inventors: Kyuson Yun, Hai-Xiao Zhai
  • Nitric oxide enhancing angiotensin II antagonist compounds, compositions and methods of use
    Publication number: 20070032533
    Abstract: The invention describes compositions and kits comprising at least one nitric oxide enhancing angiotensin II antagonist compound, or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitric oxide enhancing angiotensin II antagonist compound, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; (k) treating nephropathy; (l) treating peripheral vascular diseases; (m) treating portal hypertension (o) treating central nervous system disorders; (p) treating metabolic syndrome; and (q) treating hyperlipidemia.
    Type: Application
    Filed: August 7, 2006
    Publication date: February 8, 2007
    Applicant: NitroMed, Inc.
    Inventors: David Garvey, Xiong Cai, Xinqin Fang, Ramani Ranatunge, Shiow-Jyi Wey, Hai-Xiao Zhai
  • Pyrrolidinone derivatives
    Patent number: 6936633
    Abstract: The present invention provides pharmaceutical compositions and novel compounds useful in the treatment of conditions mediated by CCR2, MCP-1 or the interaction thereof. The compounds of the present invention are pyrrolidinones and pyrrolidine-thiones.
    Type: Grant
    Filed: December 31, 2003
    Date of Patent: August 30, 2005
    Assignee: UCB S.A.
    Inventors: Dong Zou, Olivier Dasse, Janelle Evans, Paul Higgins, Jeremy Kintigh, Rama Kondru, Eric Schwartz, Laurent Knerr, Hai-Xiao Zhai
  • Pyrrolidinone derivatives
    Publication number: 20050004180
    Abstract: The present invention provides pharmaceutical compositions and novel compounds useful in the treatment of conditions mediated by CCR2, MCP-1 or the interaction thereof. The compounds of the present invention are pyrrolidinones and pyrrolidine-thiones.
    Type: Application
    Filed: September 26, 2002
    Publication date: January 6, 2005
    Inventors: Dong Zou, Olivier Dasse, Janelle Evans, Paul Higgins, Jeremy Kintigh, Laurent Knerr, Rama Kondru, Eric Schwartz, Hai-Xiao Zhai
  • Pyrrolidinone derivatives
    Publication number: 20040157914
    Abstract: The present invention provides pharmaceutical compositions and novel compounds useful in the treatment of conditions mediated by CCR2, MCP-1 or the interaction thereof. The compounds of the present invention are pyrrolidinones and pyrrolidine-thiones.
    Type: Application
    Filed: December 31, 2003
    Publication date: August 12, 2004
    Applicant: UCB, S.A.
    Inventors: Dong Zou, Olivier Dasse, Janelle Evans, Paul Higgins, Jeremy Kintigh, Rama Kondru, Eric Schwartz, Laurent Knerr, Hai-Xiao Zhai
  • Pyrrolidinone derivatives
    Patent number: 6727275
    Abstract: The present invention provides pharmaceutical compositions and novel compounds useful in the treatment of conditions mediated by CCR2, MCP-1 or the interaction thereof. The compounds of the present invention are pyrrolidinones and pyrrolidine-thiones.
    Type: Grant
    Filed: September 26, 2002
    Date of Patent: April 27, 2004
    Assignee: UCB, S.A./N.V.
    Inventors: Dong Zou, Olivier Dasse, Janelle Evans, Paul Higgins, Jeremy Kintigh, Rama Kondru, Eric Schwartz, Laurent Knerr, Hai-Xiao Zhai
  • Pyrrolidinone derivatives
    Publication number: 20030149081
    Abstract: The present invention provides pharmaceutical compositions and novel compounds useful in the treatment of conditions mediated by CCR2, MCP-1 or the interaction thereof. The compounds of the present invention are pyrrolidinones and pyrrolidine-thiones.
    Type: Application
    Filed: September 26, 2002
    Publication date: August 7, 2003
    Inventors: Dong Zou, Olivier Dasse, Janelle Evans, Paul Higgins, Jeremy Kintigh, Rama Kondru, Eric Schwartz, Laurent Knerr, Hai-Xiao Zhai