Abstract: Provided are a bifunctional molecule capable of binding to human transforming growth factor ? (TGF?) and human programmed death-ligand 1 (PD-L1), a pharmaceutical composition comprising the same, and use thereof treating cancer. The bifunctional molecule has high affinity for PD-L1, can significantly promote the secretion of IL-2 and IFN-?, enhances T cell immune responses, and can block TGF? with high specificity, and thus can be used for treating cancer. Also provided is a monoclonal antibody or an antigen-binding fragment thereof binding to human PD-L1.

Abstract: The present invention relates to a carbide tool cleaning and coating production line and a method, including a cleaning device including a support frame, a cleaning mechanism and a drying mechanism are sequentially disposed under the support frame connected to a moving mechanism, the moving mechanism is connected to a lifting mechanism being capable of being connected to a tool fixture bracket being configured to accommodate the tool fixture; a coating device including a coating chamber which a plane target mechanism and a turntable assembly disposed in, the turntable assembly is capable of being connected to a plurality of tool fixtures being capable of rotating around an axial line of the coating chamber under the driving of the turntable assembly and rotating around an axial line thereof at the same time; and, a manipulator being disposed between the cleaning device and the coating device.

Abstract: Disclosed is a system for assessing quality of a singing voice singing a song. The system comprises memory and at least one processor. The memory stores instructions that, when executed by the at least one processor, cause the at least one processor to receive a plurality of inputs comprising a first input and one or more further inputs, each input comprising a recording of a singing voice singing the song, to determine, for the first input, one or more relative measures of quality of the singing voice by comparing the first input to each further input; and to assess quality of the singing voice of the first input based on the one or more relative measures. Also disclosed is a method implemented on such a system.

Abstract: A multi-procedure integrated automatic production line for hard alloy blades under robot control is provided. The production line includes a rail-guided robot. A cutter passivation device and a blade cleaning and drying device are arranged on one side of the rail-guided robot. A blade-coating transfer table, a blade coating device, a blade boxing transfer table, a blade-tooling dismounting device and a blade boxing device are sequentially arranged on another side of the rail-guided robot. The blade-tooling dismounting device is arranged on one side of the blade boxing transfer table. The production line further includes squirrel-cage toolings for carrying the blades. The squirrel-cage tooling that are loaded with the blades can run among the cutter passivation device, the blade cleaning and drying device, the blade-coating transfer table and the blade boxing transfer table. The blades after being treated through the blade-tooling dismounting device are sent to the blade boxing device.

Abstract: The present invention discloses a high-entropy soft magnetic alloy with 900 K high-temperature resistance, comprising Fe, Co, Ni, Si and Al, and the atomic percent of the alloy composition is expressed as FexCoyNizSimAln, wherein x=40%-80%, y=20%-60%, z=0-30%, m=0-20%, n=0-20%, and x+y+z+m+n=100%; the atomic percent of other doping elements is p=0-5%, and 0.5?m/n?3; the performance indexes of the material include: at room temperature, saturation magnetization Ms=90-150 emu/g, and coercive force Hc=0.1-15 Oe; and at 900 K, saturation magnetization Ms=70-130 emu/g, and coercive force Hc=0.1-25 Oe.

Abstract: The present application relates to a method for statistical distribution characterization of dendritic structures in original position of single crystal superalloy, and relates to the technical field of analysis of metal material composition and microstructure, comprising the following steps: step 1, processing a to-be-tested sample and determining a calibration coefficient; step 2, obtaining a two-dimensional element content distribution map of the to-be-tested sample; and step 3, determining the number and average spacing of primary dendrites. A composition distribution region analyzed in the present application is larger than the area of a distribution region of the traditional microscopic analysis method, and the sample preparation is simple. The distribution, number and average spacing of the primary dendrites can be obtained without metallographic corrosion sampling.

Abstract: An adaptive characteristic spectral line screening method and system based on atomic emission spectrum are provided, the method includes: using a set characteristic screening optimization method to perform a plurality of optimization rounds of characteristic screening, obtaining an initialized spectral dataset of each round of the characteristic screening and initialized characteristic population genes; obtaining an optimal characteristic population gene of each round by a set analysis method, a fitness function, and an iteration of a genetic algorithm; obtaining an optimized characteristic spectral information set when the plurality of optimization rounds reach set optimization rounds; performing combination statistics and discriminant analyses on the optimized characteristic spectral information set to complete an adaptive characteristic spectral line screening.

Abstract: A high-throughput 3D printing system for preparing multi-component, small sized samples, includes a raw material supply module, providing a various kinds of metal powders for printing small sized samples; the first mixer module, mixing the metal powders obtained from the raw material supply module to generate the first blended metal powders; the second mixer module, mixing the first mixed metal powders, in order to generate the second blended metal powders for printing small sized samples; the first printing module, printing the secondary blended metal powder into a small-sized sample; a control module, controlling other functional modules of the high-throughput 3D printing system for generating small-size samples.

Abstract: A turret of a scope can include a cap, a turret body connected to the cap, an electronic display wrapped circumferentially around the turret body, and a button positioned on or through a surface of the cap to engage the electronic display. In certain implementations, upon depressing the button, the electronic display presents a graphical visualization. In addition, the graphical visualization can include at least one of distance compensation data, a ballistic profile, or environmental conditions.

Abstract: An adjustment assembly for riflescopes and related methods are provided. In one example, an adjustment assembly includes a knob configured to rotate about an axis, a disc having a trace, a first sensor configured to measure a value relating to a particular portion of the trace, and a second sensor configured to sense complete revolutions of the knob about the axis. The riflescope also includes a processor configured to correlate the value with an angular displacement of the knob about the axis relative to a zero point.

Abstract: An adjustment assembly for riflescopes and related methods are provided. In one example, an adjustment assembly includes a knob configured to rotate about an axis, a disc having a trace, a first sensor configured to measure a value relating to a particular portion of the trace, and a second sensor configured to sense complete revolutions of the knob about the axis. The riflescope also includes a processor configured to correlate the value with an angular displacement of the knob about the axis relative to a zero point.

Abstract: Disclosed is a system for assessing quality of a singing voice singing a song. The system comprises memory and at least one processor. The memory stores instructions that, when executed by the at least one processor, cause the at least one processor to receive a plurality of inputs comprising a first input and one or more further inputs, each input comprising a recording of a singing voice singing the song, to determine, for the first input, one or more relative measures of quality of the singing voice by comparing the first input to each further input; and to assess quality of the singing voice of the first input based on the one or more relative measures. Also disclosed is a method implemented on such a system.

Abstract: Disclosed are a sesquiterpene derivative and a use of the same in preparation of a medicament for treating hepatitis B diseases. The sesquiterpene derivative has the effects of down-regulating the hepatocyte nuclear factor 4? (HNF-4?) and significantly inhibiting the hepatitis B virus, and can be used for preventing and/or treating and/or assisting in the treatment of liver system diseases and symptoms caused by the hepatitis B virus, and can be used as a hepatic protective agent. In addition, the synthetic sesquiterpene derivative can also be used for preventing or treating viral infectious diseases and conditions resulting from the influenza virus, coxsackievirus, herpes simplex virus, etc. Also involved is the preparation of the synthetic sesquiterpene derivative, which acts as a raw material, in clinically acceptable pharmaceutical formulations, such as oral dosage forms such as tablets, capsules and drop pills or non-oral dosage forms such as inhalants and injections.

Abstract: An optical instrument, such as a spotting scope, is provided. The optical instrument may include a range finder configured to calculate or otherwise determine a distance between the optical instrument and an identified object. The optical instrument may also include a display and a user interface. In some embodiments, an operation system associated with the optical instrument may include sensing touchless gestures. For example, hand gestures or eye gestures may be used to navigate a user interface, to actuate the laser range finder, to alter the brightness of a display, or to carry out any of a number of other operational commands.

Abstract: Disclosed are a sesquiterpene derivative and a use of the same in preparation of a medicament for treating hepatitis B diseases. The sesquiterpene derivative has the effects of down-regulating the hepatocyte nuclear factor 4? (HNF-4?) and significantly inhibiting the hepatitis B virus, and can be used for preventing and/or treating and/or assisting in the treatment of liver system diseases and symptoms caused by the hepatitis B virus, and can be used as a hepatic protective agent. In addition, the synthetic sesquiterpene derivative can also be used for preventing or treating viral infectious diseases and conditions resulting from the influenza virus, coxsackievirus, herpes simplex virus, etc. Also involved is the preparation of the synthetic sesquiterpene derivative, which acts as a raw material, in clinically acceptable pharmaceutical formulations, such as oral dosage forms such as tablets, capsules and drop pills or non-oral dosage forms such as inhalants and injections.

Abstract: An optical instrument, such as a spotting scope, is provided. The optical instrument may include a range finder configured to calculate or otherwise determine a distance between the optical instrument and an identified object. The optical instrument may also include a display and a user interface. In some embodiments, an operation system associated with the optical instrument may include sensing touchless gestures. For example, hand gestures or eye gestures may be used to navigate a user interface, to actuate the laser range finder, to alter the brightness of a display, or to carry out any of a number of other operational commands.

Abstract: Embodiments of the present invention provide a digital cinema projection method comprising the following steps: projecting images to a screen by a digital cinema projector, and acquiring the images on the screen by an image capture unit; performing digital analysis on the acquired images by an image analysis unit to obtain a plurality of parameters of the acquired images; according to each of the parameters, performing correction process on image signals input from the digital cinema server, and then outputting to the digital cinema projector; and projecting the differently corrected and improved images targeted to each of the digital cinema projectors.

Abstract: A system and method for speech-to-singing synthesis is provided. The method includes deriving characteristics of a singing voice for a first individual and modifying vocal characteristics of a voice for a second individual in response to the characteristics of the singing voice of the first individual to generate a synthesized singing voice for the second individual.

Abstract: A method for executing a fully mixed initiative dialogue (FMID) interaction between a human and a machine, a dialogue system for a FMID interaction between a human and a machine and a computer readable data storage medium having stored thereon computer code for instructing a computer processor to execute a method for executing a FMID interaction between a human and a machine are provided. The method includes retrieving a predefined grammar setting out parameters for the interaction; receiving a voice input; analyzing the grammar to dynamically derive one or more semantic combinations based on the parameters; obtaining semantic content by performing voice recognition on the voice input; and assigning the semantic content as fulfilling the one or more semantic combinations.

Abstract: Macrocyclic amide WH-21091 with antibacterial and antitumor activities, its analogs, preparation methods and uses thereof. The said macrocyclic amides are prepared by microbes of Xenorhabdus and Photorhabdus, or they can be prepared by other living beings through transgenic techniques. The compositions of the said macrocyclic amide and its analogs can be used as drugs and/or agricultural chemicals for treatment of microbial infections, especially for treatment of infectious diseases of Staphylococcus aureus with drug resistance. The said compositions can also be used as drugs for treatment of cancers of human beings or animals.