Patents by Inventor Hali Wang
Hali Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10646326Abstract: The present disclosure relates, in some aspects, to orthopaedic implants for securing soft tissue to bone and methods for using the same. One particular implant comprises a first exposed porous surface region, having pores for promoting bone ingrowth, and a second exposed porous surface, having pores for promoting soft tissue ingrowth. At least some of the pores of the first exposed porous surface region may be seeded with osteocytic factors and at least some of the pores of the second exposed porous surface region may be seeded with fibrocytic factors. Such orthopaedic implants can advantageously facilitate regeneration of the soft tissue to bone interface.Type: GrantFiled: September 20, 2017Date of Patent: May 12, 2020Assignee: Zimmer, Inc.Inventors: Tao Jiang, Jian Q. Yao, Hali Wang, Timothy A. Hoeman, Ray Zubok, John Chernosky, Keith A. Roby
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Patent number: 10167447Abstract: The present disclosure provides tissue supports and methods for preparing a cartilage composition for repairing cartilage defects, which is prepared by expanding and integrating small cartilage tissue pieces derived from donor or engineered tissue. The methods and supports described herein promote cell migration and integration of neighboring tissue pieces in culture to form the cartilage composition. Methods of cartilage repair using the cartilage composition are also described.Type: GrantFiled: June 9, 2014Date of Patent: January 1, 2019Assignee: Zimmer, Inc.Inventors: Jian Q. Yao, Hali Wang
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Publication number: 20180008399Abstract: The present disclosure relates, in some aspects, to orthopaedic implants for securing soft tissue to bone and methods for using the same. One particular implant comprises a first exposed porous surface region, having pores for promoting bone ingrowth, and a second exposed porous surface, having pores for promoting soft tissue ingrowth. At least some of the pores of the first exposed porous surface region may be seeded with osteocytic factors and at least some of the pores of the second exposed porous surface region may be seeded with fibrocytic factors. Such orthopaedic implants can advantageously facilitate regeneration of the soft tissue to bone interface.Type: ApplicationFiled: September 20, 2017Publication date: January 11, 2018Inventors: Tao Jiang, Jian Q. Yao, Hali Wang, Timothy A. Hoeman, Ray Zubok, John Chernosky, Keith A. Roby
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Patent number: 9827087Abstract: The present disclosure relates, in some aspects, to orthopedic implants for securing soft tissue to bone and methods for using the same. One particular implant comprises a first exposed porous surface region, having pores for promoting bone ingrowth, and a second exposed porous surface, having pores for promoting soft tissue ingrowth. At least some of the pores of the first exposed porous surface region may be seeded with osteocytic factors and at least some of the pores of the second exposed porous surface region may be seeded with fibrocytic factors. Such orthopedic implants can advantageously facilitate regeneration of the soft tissue to bone interface.Type: GrantFiled: June 1, 2015Date of Patent: November 28, 2017Assignee: Zimmer, Inc.Inventors: Tao Jiang, Jian Q. Yao, Hali Wang, Timothy A. Hoeman, Ray Zubok, John Chernosky, Keith A. Roby
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Patent number: 9339587Abstract: Compositions and methods for repairing a ruptured connective tissue are disclosed. The composition may include a first biocompatible material to provide a scaffold for connective tissue cell growth and tissue repair. This first biocompatible material may withstand a tensile load of up to 250 N. The composition may also include a second biocompatible material including at least one bioactive agent that can stimulate connective tissue cell growth and tissue repair. The method may include positioning a first end of the first biocompatible material adjacent a first end of a ruptured connective tissue, positioning a second end of the first biocompatible material adjacent a second end of the ruptured connective tissue, and anchoring the first biocompatible material to the first and second tendon ends. The method may alternatively comprise or further include positioning a second biocompatible material between the first and second ends of the ruptured connective tissue.Type: GrantFiled: December 22, 2008Date of Patent: May 17, 2016Assignee: Zimmer Orthobiologics, Inc.Inventors: Hali Wang, Jian Q. Yao
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Publication number: 20150257871Abstract: The present disclosure relates, in some aspects, to orthopaedic implants for securing soft tissue to bone and methods for using the same. One particular implant comprises a first exposed porous surface region, having pores for promoting bone ingrowth, and a second exposed porous surface, having pores for promoting soft tissue ingrowth. At least some of the pores of the first exposed porous surface region may be seeded with osteocytic factors and at least some of the pores of the second exposed porous surface region may be seeded with fibrocytic factors. Such orthopaedic implants can advantageously facilitate regeneration of the soft tissue to bone interface.Type: ApplicationFiled: June 1, 2015Publication date: September 17, 2015Inventors: Tao Jiang, Jian Q. Yao, Hali Wang, Timothy A. Hoeman, Ray Zubok, John Chernosky, Keith A. Roby
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Patent number: 9055977Abstract: The present disclosure relates, in some aspects, to orthopaedic implants for securing soft tissue to bone and methods for using the same. One particular implant comprises a first exposed porous surface region, having pores for promoting bone ingrowth, and a second exposed porous surface, having pores for promoting soft tissue ingrowth. At least some of the pores of the first exposed porous surface region may be seeded with osteocytic factors and at least some of the pores of the second exposed porous surface region may be seeded with fibrocytic factors. Such orthopaedic implants can advantageously facilitate regeneration of the soft tissue to bone interface.Type: GrantFiled: November 16, 2012Date of Patent: June 16, 2015Assignee: Zimmer, Inc.Inventors: Tao Jiang, Jian Q. Yao, Hali Wang, Timothy A. Hoeman, Ray Zubok, John Chernosky, Keith A. Roby
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Publication number: 20140335612Abstract: The present disclosure provides tissue supports and methods for preparing a cartilage composition for repairing cartilage defects, which is prepared by expanding and integrating small cartilage tissue pieces derived from donor or engineered tissue. The methods and supports described herein promote cell migration and integration of neighboring tissue pieces in culture to form the cartilage composition. Methods of cartilage repair using the cartilage composition are also described.Type: ApplicationFiled: June 9, 2014Publication date: November 13, 2014Inventors: Jian Q. Yao, Hali Wang
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Publication number: 20140178343Abstract: The present disclosure provides tissue supports and methods for preparing a cartilage composition for repairing cartilage defects, which is prepared by expanding and integrating small cartilage tissue pieces derived from donor or engineered tissue. The methods and supports described herein promote cell migration and integration of neighboring tissue pieces in culture to form the cartilage composition. Methods of cartilage repair using the cartilage composition are also described.Type: ApplicationFiled: March 13, 2013Publication date: June 26, 2014Inventors: Jian Q. Yao, Hali Wang
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Patent number: 8608759Abstract: Medical devices for cutting and suturing biological tissue generally include a shaft and first and second guide members each including a first portion coupled to the shaft at a first location and a second portion coupled to the shaft at a second location. The first portions are movable along the shaft relative to the second portions, and the first and second guide members define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device may further include a blade positioned between the first and second guide members. When used to suture tissue, one or more suture guides may be provided on the first guide member for directing a suture needle through tissue proximate the first guide member. Methods of repairing and replacing a meniscus using the medical devices are also provided.Type: GrantFiled: March 21, 2012Date of Patent: December 17, 2013Assignee: Zimmer Orthobiologics, Inc.Inventors: Victor Zaporojan, Jian Q. Yao, Rodney E. Bristol, Hui Liu, Hali Wang, Hai-Qing Xian
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Publication number: 20130131699Abstract: The present disclosure relates, in some aspects, to orthopaedic implants for securing soft tissue to bone and methods for using the same. One particular implant comprises a first exposed porous surface region, having pores for promoting bone ingrowth, and a second exposed porous surface, having pores for promoting soft tissue ingrowth. At least some of the pores of the first exposed porous surface region may be seeded with osteocytic factors and at least some of the pores of the second exposed porous surface region may be seeded with fibrocytic factors. Such orthopaedic implants can advantageously facilitate regeneration of the soft tissue to bone interface.Type: ApplicationFiled: November 16, 2012Publication date: May 23, 2013Applicant: Zimmer, Inc.Inventors: Tao Jiang, Jian Q. Yao, Hali Wang, Timothy A. Hoeman, Ray Zubok, John Chernosky, Keith A. Roby
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Publication number: 20120179173Abstract: Medical devices for cutting and suturing biological tissue generally include a shaft and first and second guide members each including a first portion coupled to the shaft at a first location and a second portion coupled to the shaft at a second location. The first portions are movable along the shaft relative to the second portions, and the first and second guide members define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device may further include a blade positioned between the first and second guide members. When used to suture tissue, one or more suture guides may be provided on the first guide member for directing a suture needle through tissue proximate the first guide member. Methods of repairing and replacing a meniscus using the medical devices are also provided.Type: ApplicationFiled: March 21, 2012Publication date: July 12, 2012Applicant: Zimmer Orthobiologics, Inc.Inventors: Victor Zaporojan, Jian Q. Yao, Rodney Bristol, Hui Liu, Hali Wang, Hai-Qing Xian
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Patent number: 8162961Abstract: Medical devices for cutting and suturing biological tissue generally include a shaft and first and second guide members each including a first portion coupled to the shaft at a first location and a second portion coupled to the shaft at a second location. The first portions are movable along the shaft relative to the second portions, and the first and second guide members define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device may further include a blade positioned between the first and second guide members. When used to suture tissue, one or more suture guides may be provided on the first guide member for directing a suture needle through tissue proximate the first guide member. Methods of repairing and replacing a meniscus using the medical devices are also provided.Type: GrantFiled: July 23, 2007Date of Patent: April 24, 2012Assignee: Zimmer Orthobiologies, Inc.Inventors: Victor Zaporojan, Jian Q. Yao, Rodney Bristol, Hui Liu, Hali Wang, Hai-Qing Xian
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Publication number: 20110110888Abstract: A system and method for producing a scaffold coated and/or impregnated with at least one bioactive agent. This is accomplished by culturing at least one cell in the same medium as a scaffold, but without physical contact between the at least one cell and the scaffold. The system includes a container having a surface defining an interior compartment. A medium is disposed within the interior compartment. At least one cell is disposed within the medium, the at least one cell being capable of producing at least one bioactive agent. Further, a scaffold is disposed within the medium. The scaffold is physically separated from the at least one cell such that there is no contact between the scaffold and the at least one cell. Thus, as the at least one cell produces at least one bioactive agent, such as a growth factor, the at least one bioactive agent enters the medium, and contacts and coats and/or impregnates the scaffold.Type: ApplicationFiled: June 26, 2009Publication date: May 12, 2011Inventors: Hai-Qing Xian, Jian Q. Yao, Hali Wang, Massoud Daheshia, Hui Liu
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Publication number: 20110111028Abstract: Compositions and methods for repairing a ruptured connective tissue are disclosed. The composition may include a first biocompatible material to provide a scaffold for connective tissue cell growth and tissue repair. This first biocompatible material may withstand a tensile load of up to 250 N. The composition may also include a second biocompatible material including at least one bioactive agent that can stimulate connective tissue cell growth and tissue repair. The method may include positioning a first end of the first biocompatible material adjacent a first end of a ruptured connective tissue, positioning a second end of the first biocompatible material adjacent a second end of the ruptured connective tissue, and anchoring the first biocompatible material to the first and second tendon ends. The method may alternatively comprise or further include positioning a second biocompatible material between the first and second ends of the ruptured connective tissue.Type: ApplicationFiled: December 22, 2008Publication date: May 12, 2011Inventors: Hali Wang, Jian Q. Yao
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Publication number: 20100297766Abstract: A method of removing undesired tissue from a connective tissue is provided that includes stretching the connective tissue and peeling away the undesired tissue. Some methods include soaking the connective tissue in a solution prior to and/or subsequent to stretching and peeling away the undesired tissue. The solution may include a detergent, an enzyme, a salt solution, an organic solvent, and combinations thereof.Type: ApplicationFiled: February 3, 2009Publication date: November 25, 2010Inventors: Hai-Qing Xian, Hali Wang, Hui Liu, Jian Q. Yao, Jizong Gao
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Publication number: 20090030431Abstract: Medical devices for cutting and suturing biological tissue generally include a shaft and first and second guide members each including a first portion coupled to the shaft at a first location and a second portion coupled to the shaft at a second location. The first portions are movable along the shaft relative to the second portions, and the first and second guide members define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device may further include a blade positioned between the first and second guide members. When used to suture tissue, one or more suture guides may be provided on the first guide member for directing a suture needle through tissue proximate the first guide member. Methods of repairing and replacing a meniscus using the medical devices are also provided.Type: ApplicationFiled: July 23, 2007Publication date: January 29, 2009Applicant: ZIMMER ORTHOBIOLOGICS, INC.Inventors: Victor Zaporojan, Jian Q. Yao, Rodney Bristol, Hui Liu, Hali Wang, Hai-Qing Xian
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Publication number: 20080306610Abstract: Methods for processing tissues to render them suitable for implantation, e.g. in an orthopedic site. Tissues are rendered substantially acellular and substantially nonimmunogenic by exposure to processes that result in cell lysis, increasing permeability of the extracellular matrix, degrading the debris from lysis, and removing the debris. Methods of forming tissue implants, kits for processing tissue implants, and methods of using tissue implants are also disclosed.Type: ApplicationFiled: June 7, 2007Publication date: December 11, 2008Applicant: ZIMMER ORTHOBIOLOGICS, INC.Inventors: Hali Wang, Hui Liu, Hai-Qing Xian, Jian Q. Yao, Victor Zaporojan
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Publication number: 20080294270Abstract: A method of preparing an implantable biological device having a first tissue part and a second tissue part includes exposing the first tissue part to a first preparation method and preventing exposure of the second biological tissue part to the first preparation method. Preventing exposure of the second biological tissue part to the first preparation method may be achieved using an embedding technique, a coating technique, a covering technique, or physical isolation. The method may further include exposing the second tissue part to a second preparation method and preventing exposure of the first biological tissue part to the second preparation method. An apparatus for preparing an implantable biologic device includes an enclosure having first and second chambers separated by a partition member wherein a substantial portion of the first tissue part is within the first chamber and a substantial portion of the second tissue part is within the second chamber.Type: ApplicationFiled: May 24, 2007Publication date: November 27, 2008Applicant: ZIMMER ORTHOBIOLOGICS, INC.Inventors: Jian Q. Yao, Hai-Qing Xian, Jizong Gao, Rodney Bristol, Victor Zaporojan, Hali Wang, Hui Liu