Patents by Inventor Hallie Graor

Hallie Graor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of generating tumor-specific T cells
    Patent number: 11071754
    Abstract: A method of treating cancer in a subject includes contacting an enriched population of T-cells obtained from cancer or tumor draining lymph nodes ex-vivo with: an anti-CD3 antibody, an anti-CD28 antibody, and/or functional fragments thereof, and optionally a VEGF inhibitor and/or an IL-2 receptor agonist, at amounts effective to activate and expand the T-cells and administering the activated and expanded T-cells to the subject.
    Type: Grant
    Filed: April 16, 2018
    Date of Patent: July 27, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Julian Kim, Kevin Choong, Hallie Graor, Mei Zhang, John Ammori, Anthony Visioni
  • METHOD OF GENERATING TUMOR-SPECIFIC T CELLS
    Publication number: 20180228844
    Abstract: A method of treating cancer in a subject includes contacting an enriched population of T-cells obtained from cancer or tumor draining lymph nodes ex-vivo with: an anti-CD3 antibody, an anti-CD28 antibody, and/or functional fragments thereof, and optionally a VEGF inhibitor and/or an IL-2 receptor agonist, at amounts effective to activate and expand the T-cells and administering the activated and expanded T-cells to the subject.
    Type: Application
    Filed: April 16, 2018
    Publication date: August 16, 2018
    Inventors: Julian Kim, Kevin Choong, Hallie Graor, Mei Zhang, John Ammori, Anthony Visioni
  • Method of generating tumor-specific T cells
    Patent number: 9944898
    Abstract: A method for the expansion of tumor-specific T-cells includes obtaining an enriched population of T-cells from a subject with cancer; and contacting the enriched population of T-cells ex-vivo with: (i) an anti-CD3 antibody, an anti-CD28 antibody, and/or functional fragments thereof, and (ii) a VEGF inhibitor, to activate and expand the T-cells.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: April 17, 2018
    Assignee: Case Western Reserve University
    Inventors: Julian Kim, Hallie Graor, Mei Zhang, Anthony Visioni
  • METHOD OF GENERATING TUMOR-SPECIFIC T CELLS
    Publication number: 20140255368
    Abstract: A method for the expansion of tumor-specific T-cells includes obtaining an enriched population of T-cells from a subject with cancer; and contacting the enriched population of T-cells ex-vivo with: (i) an anti-CD3 antibody, an anti-CD28 antibody, and/or functional fragments thereof, and (ii) a VEGF inhibitor, to activate and expand the T-cells.
    Type: Application
    Filed: March 11, 2014
    Publication date: September 11, 2014
    Inventors: Julian Kim, Hallie Graor, Mei Zhang, Anthony Visioni