Patents by Inventor Halong N. Vu

Halong N. Vu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stable retrovirus and methods of use
    Patent number: 7485446
    Abstract: The present invention is a mutant retroviral protease which confers an increase in retroviral stability. Retroviruses expressing the instant mutant retroviral protease exhibit at least a 2-fold increase in infectivity half-life as compared to wild-type retrovirus. Unexpectedly, a Gly119Glu mutation in the protease enhances retroviral stability in the presence of various wild-type envelope proteins including wild-type amphotropic, ecotropic and 10A1 murine leukemia viruses. The improved stability of the mutant retrovirus leads to more facile virus production and enhanced infection efficiency.
    Type: Grant
    Filed: February 21, 2007
    Date of Patent: February 3, 2009
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Halong N. Vu, Daniel W. Pack, Joshua Ramsey
  • Stable retrovirus and methods of use
    Publication number: 20070196386
    Abstract: The present invention is a mutant retroviral protease which confers an increase in retroviral stability. Retroviruses expressing the instant mutant retroviral protease exhibit at least a 2-fold increase in infectivity half-life as compared to wild-type retrovirus. Unexpectedly, a Gly119Glu mutation in the protease enhances retroviral stability in the presence of various wild-type envelope proteins including wild-type amphotropic, ecotropic and 10A1 murine leukemia viruses. The improved stability of the mutant retrovirus leads to more facile virus production and enhanced infection efficiency.
    Type: Application
    Filed: February 21, 2007
    Publication date: August 23, 2007
    Inventors: Halong N. Vu, Daniel W. Pack, Joshua Ramsey