Abstract: The present invention relates to novel nitroimidazooxazines, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.

Abstract: A method for applying a coating to a surface includes providing a sprayable liquid binding agent formed of first and second components, pumping the first and second components of the binding agent to a first dispensing device and combining the first and second components in the first dispensing device to form the binding agent. The method further includes spraying the binding agent from the first dispensing device on to a surface to be coated, providing a particulate medium, and spraying the particulate medium from a second dispensing device into the liquid spray of binding agent produced by the first dispensing device. The binding agent may coat the particulate medium and adhere it to the surface to form a coating thereon. An apparatus for performing the method is also described.

Abstract: A bracket assembly 2 for providing an attachment point on a surface for supporting an article. The bracket assembly 2 includes a body member 6 arranged so as to be held against a region of the surface by way of magnetic association therewith. The body member has a support region 7 from which the article may be supported. The body member 6 may be arranged so that, when in use, the support region 7 is spaced from the surface.

Abstract: A method for applying a coating to a surface comprising providing a sprayable liquid binding agent formed of first and second components, pumping the first and second components of the binding agent to a first dispensing device (13) and combining the first and second components in the first dispensing device (13) to form the binding agent. The method further comprises spraying the binding agent from the first dispensing device (13) on to a surface to be coated (32), providing a particulate medium, and spraying the particulate medium from a second dispensing device (37) into the liquid spray of binding agent produced by the first dispensing device (13). The binding agent coating the particulate medium and adhering it to the surface (32) to form a coating thereon. An apparatus for performing the method is also described.

Abstract: The present invention relates to novel nitroimidazooxazines, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.

Abstract: The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild-type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as Mycobacterium tuberculosis.

Abstract: The present invention relates to substituted ring fused azines and methods of using said compounds in treating cancers. More specifically, the present invention relates to the preparation of 4-alkyl-2-(heterocyclic)-azines and their use as cancer agents or drugs for cancer therapy. The compounds of the invention display favourable in vivo and in vitro activity against selected cancers.

Abstract: The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild-type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as Mycobacterium tuberculosis.

Abstract: Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.

Abstract: Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.

Abstract: The present invention relates generally to mammalian ?-N-acetyglucosaminidase and to genetic sequences encoding same and to their use in the investigation, diagnosis and treatment of subjects suspected of or suffering from ?-N-acetyglucosaminidase deficiency.

Abstract: Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.

Abstract: The present invention relates to a novel gene, a novel protein encoded by said gene, a mutated form of the gene and to diagnostic and therapeutic uses of the gene or a mutated form thereof. More specifically, the present invention relates to a novel gene defective in autoimmune polyendocrinopathy syndrome type I (APS I), also called autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) (MIM No. 240,300).

Abstract: The present invention relates to a method for the diagnosis of a disease related to immune maturation and regulation of immune response towards self and nonself, comprising the steps of detecting in a biological specimen the presence of a DNA sequence comprising the sequence of SEQ ID NO:1.