Patents by Inventor Han Altae-Tran

Han Altae-Tran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REPROGRAMMABLE TNPB POLYPEPTIDES AND USE THEREOF
    Publication number: 20240084332
    Abstract: Systems, methods and composition for targeting polynucleotides are detailed herein. In particular, engineered DNA-targeting systems comprising novel TnpB polypeptides and a reprogrammable targeting nucleic acid component and methods and application of use are provided.
    Type: Application
    Filed: January 25, 2022
    Publication date: March 14, 2024
    Inventors: Feng Zhang, Han Altae-Tran, Soumya Kannan, Suchita Nety
  • SMALL TYPE II-D CAS PROTEINS AND METHODS OF USE THEREOF
    Publication number: 20240026382
    Abstract: Described herein are systems, methods, and compositions capable of targeting nucleic acids. Describe in certain exemplary embodiments herein are a class of small Cas proteins (Type II-D Cas proteins) and systems thereof. Also described in certain exemplary embodiments herein are methods of modifying target sequences using the class of small Cas proteins (Type II-D Cas proteins) and systems thereof described herein.
    Type: Application
    Filed: September 19, 2023
    Publication date: January 25, 2024
    Inventors: Feng Zhang, Soumya Kannan, Han Altae-Tran
  • Rapid diagnostics
    Patent number: 11851702
    Abstract: Systems and methods for rapid diagnostics related to the use of isothermal amplification reagents for detection of microbial species, including coronavirus, and methods of use, are provided.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: December 26, 2023
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Jonathan Gootenberg, Omar Abudayyeh, Julia Joung, Alim Ladha, Han Altae-Tran, Guilhem Faure
  • REPROGRAMMABLE ISCB NUCLEASES AND USES THEREOF
    Publication number: 20230392131
    Abstract: Systems, methods and compositions for targeting polynucleotides are detailed herein. In particular, engineered DNA-targeting systems comprising IscB polypeptides, novel IscB nucleases and reprogrammable targeting nucleic acid components and methods and application of use are provided.
    Type: Application
    Filed: October 22, 2021
    Publication date: December 7, 2023
    Inventors: Feng Zhang, Han Altae-Tran, Soumya Kannan, Fatma Esra Demircioglu
  • NUCLEIC ACID-GUIDED NUCLEASES AND USE THEREOF
    Publication number: 20230383272
    Abstract: Systems, methods, and compositions for targeting polynucleotides. More particularly, the disclosure provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting nucleic acid-guided nuclease and at least one targeting nucleic acid component like a guide RNA.
    Type: Application
    Filed: October 22, 2021
    Publication date: November 30, 2023
    Inventors: Feng Zhang, Soumya Kannan, Han Altae-Tran
  • SMALL TYPE II-D CAS PROTEINS AND METHODS OF USE THEREOF
    Publication number: 20230340537
    Abstract: Described herein are systems, methods, and compositions capable of targeting nucleic acids. Describe in certain exemplary embodiments herein are a class of small Cas proteins (Type II-D Cas proteins) and systems thereof. Also described in certain exemplary embodiments herein are methods of modifying target sequences using the class of small Cas proteins (Type II-D Cas proteins) and systems thereof described herein.
    Type: Application
    Filed: January 15, 2021
    Publication date: October 26, 2023
    Inventors: Feng Zhang, Soumya Kannan, Han Altae-Tran
  • Type V CRISPR-Cas systems and use thereof
    Patent number: 11639523
    Abstract: Engineered or non-naturally occurring systems and compositions comprising a novel Cas12b and a guide molecule. Also provided include methods of use the systems and compositions, including in treating and diagnosing diseases.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: May 2, 2023
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Jonathan Gootenberg, Omar Abudayyeh, Julia Joung, Alim Ladha, Han Altae-Tran, Guilhem Faure
  • FIELD DEPLOYABLE CRISPR-CAS DIAGNOSTICS AND METHODS OF USE THEREOF
    Publication number: 20230127948
    Abstract: Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences for detection of coronavirus, including multiplex lateral flow diagnostic devices and methods of use, are provided.
    Type: Application
    Filed: February 12, 2021
    Publication date: April 27, 2023
    Inventors: Jonathan Gootenberg, Omar Abudayyeh, Julia Joung, Alim Ladha, Han Altae-Tran, Guilhem Faure, Feng Zhang
  • NOVEL TYPE IV AND TYPE I CRISPR-CAS SYSTEMS AND METHODS OF USE THEREOF
    Publication number: 20230087228
    Abstract: The present disclosure provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides novel class 1, Type IV and novel class I, Type I Cas proteins and their use in modifying target sequences.
    Type: Application
    Filed: February 24, 2021
    Publication date: March 23, 2023
    Inventors: Feng Zhang, Han Altae-Tran, Soumya Kannan
  • PROGRAMMABLE DNA NUCLEASE-ASSOCIATED LIGASE AND METHODS OF USE THEREOF
    Publication number: 20230037794
    Abstract: Described in certain exemplary embodiments herein are programmable DNA nuclease systems and/or components thereof that include or are otherwise associated with a ligase. Also described in certain exemplary embodiments herein are method of using the DNA nuclease systems described herein to modify a nucleic acid sequence.
    Type: Application
    Filed: December 23, 2020
    Publication date: February 9, 2023
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Han Altae-Tran
  • NOVEL TYPE VI CRISPR ENZYMES AND SYSTEMS
    Publication number: 20230025039
    Abstract: The present disclosure provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides Cas proteins and their use in modifying target sequences.
    Type: Application
    Filed: September 18, 2020
    Publication date: January 26, 2023
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Han Altae-Tran, Soumya Kannan
  • SMALL TYPE II CAS PROTEINS AND METHODS OF USE THEREOF
    Publication number: 20220403357
    Abstract: The present disclosure provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides small Cas proteins and their use in modifying target sequences. In one aspect, the present disclosure provides a non-naturally occurring or engineered system comprising: a Cas protein that comprises a RuvC domain and a HNH domain, and is less than 850 amino acids in size; and a guide sequence capable of forming a complex with the Cas protein and directing the complex to bind to a target sequence.
    Type: Application
    Filed: November 12, 2020
    Publication date: December 22, 2022
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Soumya Kannan, Han Altae-Tran
  • CRISPR EFFECTOR SYSTEM BASED CORONAVIRUS DIAGNOSTICS
    Publication number: 20220325334
    Abstract: Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences for detection of coronavirus, including multiplex lateral flow diagnostic devices and methods of use, are provided.
    Type: Application
    Filed: April 27, 2022
    Publication date: October 13, 2022
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Jonathan Gootenberg, Omar Abudayyeh, Julia Joung, Alim Ladha, Han Altae-Tran, Guilhem Faure
  • Crispr effector system based coronavirus diagnostics
    Patent number: 11453907
    Abstract: Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences for detection of coronavirus, including multiplex lateral flow diagnostic devices and methods of use, are provided.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: September 27, 2022
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Jonathan Gootenberg, Omar Abudayyeh, Julia Joung, Alim Ladha, Han Altae-Tran, Guilhem Faure
  • CRISPR-ASSOCIATED MU TRANSPOSASE SYSTEMS
    Publication number: 20220298501
    Abstract: Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and transposable elements.
    Type: Application
    Filed: August 28, 2020
    Publication date: September 22, 2022
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Han Altae-Tran, Soumya Kannan
  • NOVEL CRISPR-CAS SYSTEMS AND USES THEREOF
    Publication number: 20220235340
    Abstract: The disclosure provides for systems, methods, and compositions for targeting polynucleotides. More particularly, the disclosure provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA and wherein the CRISPR effector protein is a Cas protein.
    Type: Application
    Filed: May 20, 2020
    Publication date: July 28, 2022
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Han Altae-Tran
  • NON-CLASS I MULTI-COMPONENT NUCLEIC ACID TARGETING SYSTEMS
    Publication number: 20220220469
    Abstract: Described herein are non-Class I engineered CRISPR-Cas systems and components thereof, formulations thereof, cells thereof, and organisms thereof. Methods of making and using the CRISPR-Cas system described herein.
    Type: Application
    Filed: May 20, 2020
    Publication date: July 14, 2022
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Han Altae-Tran
  • TYPE VII CRISPR PROTEINS AND SYSTEMS
    Publication number: 20220177863
    Abstract: The present application provides systems, methods and compositions used for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of Type VII Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and transposable elements.
    Type: Application
    Filed: March 18, 2020
    Publication date: June 9, 2022
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Han Altae-Tran
  • RAPID DIAGNOSTICS
    Publication number: 20210292823
    Abstract: Systems and methods for rapid diagnostics related to the use of isothermal amplification reagents for detection of microbial species, including coronavirus, and methods of use, are provided.
    Type: Application
    Filed: June 5, 2020
    Publication date: September 23, 2021
    Inventors: Feng Zhang, Jonathan Gootenberg, Omar Abudayyeh, Julia Joung, Alim Ladha, Han Altae-Tran, Guilhem Faure
  • NOVEL TYPE V CRISPR-CAS SYSTEMS AND USE THEREOF
    Publication number: 20210292721
    Abstract: Engineered or non-naturally occurring systems and compositions comprising a novel Cas12b and a guide molecule. Also provided include methods of use the systems and compositions, including in treating and diagnosing diseases.
    Type: Application
    Filed: June 5, 2020
    Publication date: September 23, 2021
    Inventors: Feng Zhang, Jonathan Gootenberg, Omar Abudayyeh, Julia Joung, Alim Ladha, Han Altae-Tran, Guilhem Faure