Patents by Inventor Hanli Liu
Hanli Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11962314Abstract: With respect to a phase locked loop (PLL) circuit that receives a first reference clock and generates an output clock, the PLL circuit includes a delay circuit that delays the first reference clock to generate a second reference clock, a feedback circuit that generates a control signal based on a phase difference between the second reference clock and a feedback clock, an oscillator that oscillates at a frequency determined based on the control signal to generate the output clock, and a divider that divides the output clock in the on state. The PLL circuit switches between a first mode and a second mode, the feedback clock in the first mode is a signal obtained by retiming an output of the divider with the output clock, and the feedback clock in the second mode is a signal obtained by retiming the first reference clock with the output clock.Type: GrantFiled: August 12, 2021Date of Patent: April 16, 2024Assignee: SOCIONEXT INC.Inventors: Kenichi Okada, Hanli Liu, Zheng Sun
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Patent number: 11883236Abstract: A diagnostic imaging device includes a probe that uses both an ultrasound transducer and frequency-domain diffuse optical imaging (FD-DOI) to assist with locating and diagnosing sub-tissue anomalies. According to one aspect, the diagnostic imaging device relates to a clip-on cap that can be utilized with existing ultrasound transducers. The diagnostic imaging device described herein can be utilized for image-guided needle biopsy to regions where prostate tissues are highly suspicious for high-grade cancer, as well as for image guided interventions, such as cryotherapy, photodynamic therapy, and brachytherapy for early-stage or localized prostate cancer.Type: GrantFiled: April 29, 2015Date of Patent: January 30, 2024Assignee: The Board of Regents of the University of Texas SystemInventors: Hanli Liu, Venkaiah C. Kavuri
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Publication number: 20210376841Abstract: With respect to a phase locked loop (PLL) circuit that receives a first reference clock and generates an output clock, the PLL circuit includes a delay circuit that delays the first reference clock to generate a second reference clock, a feedback circuit that generates a control signal based on a phase difference between the second reference clock and a feedback clock, an oscillator that oscillates at a frequency determined based on the control signal to generate the output clock, and a divider that divides the output clock in the on state. The PLL circuit switches between a first mode and a second mode, the feedback clock in the first mode is a signal obtained by retiming an output of the divider with the output clock, and the feedback clock in the second mode is a signal obtained by retiming the first reference clock with the output clock.Type: ApplicationFiled: August 12, 2021Publication date: December 2, 2021Inventors: Kenichi OKADA, Hanli LIU, Zheng SUN
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Publication number: 20170049417Abstract: A diagnostic imaging device includes a probe that uses both an ultrasound transducer and frequency-domain diffuse optical imaging (FD-DOI) to assist with locating and diagnosing sub-tissue anomalies. According to one aspect, the diagnostic imaging device relates to a clip-on cap that can be utilized with existing ultrasound transducers. The diagnostic imaging device described herein can be utilized for image-guided needle biopsy to regions where prostate tissues are highly suspicious for high-grade cancer, as well as for image guided interventions, such as cryotherapy, photodynamic therapy, and brachytherapy for early-stage or localized prostate cancer.Type: ApplicationFiled: April 29, 2015Publication date: February 23, 2017Inventors: Hanli LIU, Venkaiah C. KAVURI
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Patent number: 9226731Abstract: The present invention includes an apparatus, system and method for detection of tissues, e.g., a cancer, by optical biopsy comprising: a motorized computer-controlled probe holder; a needle-like probe connected to and controlled by the motorized computer-controlled probe holder, the probe comprising an optical and an ultrasound detector; and one or more detector units capable of a broadband light reflectance spectroscopy, an auto fluorescence lifetime measurement, and auto fluorescence spectroscopy measurement.Type: GrantFiled: September 1, 2011Date of Patent: January 5, 2016Assignee: The Board of Regents of the University of Texas SystemInventors: Hanli Liu, Vikrant Sharma
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Patent number: 8649849Abstract: The present invention includes using optical spectroscopy as an innovative technique for ex-vivo demonstration of renal and prostate tumors. The apparatus and methods disclosed herein demonstrate the ability of optical spectroscopy to reliably differentiate tumor from normal tissue in renal specimens.Type: GrantFiled: May 21, 2008Date of Patent: February 11, 2014Assignee: Board of Regents, The University of Texas SystemInventors: Hanli Liu, Jeffrey A. Cadeddu, Disha L. Peswani
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Publication number: 20110319759Abstract: The present invention includes an apparatus, system and method for detection of tissues, e.g., a cancer, by optical biopsy comprising: a motorized computer-controlled probe holder; a needle-like probe connected to and controlled by the motorized computer-controlled probe holder, the probe comprising an optical and an ultrasound detector; and one or more detector units capable of a broadband light reflectance spectroscopy, an auto fluorescence lifetime measurement, and auto fluorescence spectroscopy measurement.Type: ApplicationFiled: September 1, 2011Publication date: December 29, 2011Applicant: The Board of Regents of the University of Texas SystemInventors: Hanli Liu, Vikrant Sharma
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Publication number: 20100198080Abstract: The present invention includes using optical spectroscopy as an innovative technique for ex-vivo demonstration of renal and prostate tumors. The apparatus and methods disclosed herein demonstrate the ability of optical spectroscopy to reliably differentiate tumor from normal tissue in renal specimens.Type: ApplicationFiled: May 21, 2008Publication date: August 5, 2010Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Hanli Liu, Jeffrey A. Cadeddu, Disha L. Peswani
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Publication number: 20100160791Abstract: The present invention includes apparatus and method to prevent surgical injury. The invention incorporates near infrared (NIR) spectroscopy, which capitalizes on near infrared light's ability to penetrate deeply into tissues and spectroscopic capability to discern tissue's chemical properties. The present invention further characterized the NIR optical properties of bile containing structures as a clinically useful probe.Type: ApplicationFiled: May 21, 2008Publication date: June 24, 2010Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Hanli Liu, Edward Livingston, Bo Ping Wang
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Publication number: 20060264760Abstract: A multi-channel, near infrared (NIR) imaging system comprising one or more optical fiber bundles; and a transrectal NIR probe having an outer material, wherein the optical fiber bundle is integrated into the transrectal probe (an end-fire or a side-fire NIR probe). The outer material is preferably rubber-like silicon or made of two translucent materials exhibiting low viscosity and requires curing at room temperature. The transrectal NIR probe comprises a curvature to match the curvature of a human rectum and may have a circular or oval-shaped silicone holder. The imaging system further comprises a broad-band light source adapted to deliver light to the fiber channels, an optical switch box adapted to allow only one of the fiber channels to pass through at a time; and a multi-channel spectrometer to capture tomographic images of changes in HbO, HbT, light scattering patterns and hemodynamic response times from human prostate.Type: ApplicationFiled: February 10, 2006Publication date: November 23, 2006Applicant: Board of Regents, The University of Texas SystemInventors: Hanli Liu, Thomas Truelson
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Publication number: 20060149142Abstract: This invention is a scheme for monitoring a solute in a biological system comprising the steps of delivering light into a biological system (12) containing a solute, the light having a wavelength selected to be in a range wherein the solute is substantially non-absorbing; detecting at least first and second portions of the delivered light, the first portion having traveled through the biological system along one or more paths characterized by a first average path length, and the second portion having traveled through the biological system along one or more paths characterized by a second average path length that is greater than the first average path length; and comparing the first and second portions of the delivered light to monitor concentration of the solute in the biological system.Type: ApplicationFiled: October 14, 2005Publication date: July 6, 2006Inventors: Britton Chance, Hanli Liu
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Patent number: 6957094Abstract: This invention is a scheme for monitoring a solute in a biological system comprising the steps of delivering light into a biological system (12) containing a solute, the light having a wavelength selected to be in a range wherein the solute is substantially non-absorbing; detecting at least first and second portions of the delivered light, the first portion having traveled through the biological system along one or more paths characterized by a first average path length, and the second portion having traveled through the biological system along one or more paths characterized by a second average path length that is greater than the first average path length; and comparing the first and second portions of the delivered light to monitor concentration of the solute in the biological system.Type: GrantFiled: November 19, 2002Date of Patent: October 18, 2005Assignee: Non-Invasive Technology, Inc.Inventors: Britton Chance, Hanli Liu
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Publication number: 20040006274Abstract: Method and apparatus for probe localization in brain matter. A method is disclosed for determining the insertion point for an object at a desired location within tissue of varying types. The parameters of tissue are first measured at an entry point into the tissue from exterior thereof. The parameters of the tissue are then measured periodically along a line extending from the entry point and moving away therefrom. A determination is then made if at least one boundary between tissue types has occurred during the measurement process. The measurements along the line are then compared to a predetermined map of the tissue boundaries. Thereafter, a point on the map is then selected corresponding to the desired location within the tissue when the measured parameters indicate that the measurements are taking place in proximity thereto.Type: ApplicationFiled: May 20, 2003Publication date: January 8, 2004Inventors: Cole Giller, Hanli Liu
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Publication number: 20030166997Abstract: This invention is a scheme for monitoring a solute in a biological system comprising the steps of delivering light into a biological system (12) containing a solute, the light having a wavelength selected to be in a range wherein the solute is substantially non-absorbing; detecting at least first and second portions of the delivered light, the first portion having traveled through the biological system along one or more paths characterized by a first average path length, and the second portion having traveled through the biological system along one or more paths characterized by a second average path length that is greater than the first average path length; and comparing the first and second portions of the delivered light to monitor concentration of the solute in the biological system.Type: ApplicationFiled: November 19, 2002Publication date: September 4, 2003Inventors: Britton Chance, Hanli Liu
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Patent number: 6567690Abstract: Method and apparatus for probe localization in brain matter. A method is disclosed for determining the insertion point for an object at a desired location within tissue of varying types. The parameters of tissue are first measured at an entry point into the tissue from exterior thereof. The parameters of the tissue are then measured periodically along a line extending from the entry point and moving away therefrom. A determination is then made if at least one boundary between tissue types has occurred during the measurement process. The measurements along the line are then compared to a predetermined map of the tissue boundaries. Thereafter, a point on the map is then selected corresponding to the desired location within the tissue when the measured parameters indicate that the measurements are taking place in proximity thereto.Type: GrantFiled: May 3, 2001Date of Patent: May 20, 2003Inventors: Cole Giller, Hanli Liu
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Patent number: 6493565Abstract: This invention is a scheme for monitoring a solute in a biological system comprising the steps of delivering light into a biological system (12) containing a solute, the light having a wavelength selected to be in a range wherein the solute is substantially non-absorbing; detecting at least first and second portions of the delivered light (16, 18, 20), the first portion having traveled through the biological system along one or more paths characterized by a first average path length, and the second portion having traveled through the biological system along one or more as characterized by a second average path length that is greater than the first average path length; and comparing the first and second portions of the delivered light to monitor concentration of the solute in the biological system.Type: GrantFiled: November 17, 1997Date of Patent: December 10, 2002Assignee: Non-Invasive Technology, Inc.Inventors: Britton Chance, Hanli Liu
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Publication number: 20020045832Abstract: Method and apparatus for probe localization in brain matter. A method is disclosed for determining the insertion point for an object at a desired location within tissue of varying types. The parameters of tissue are first measured at an entry point into the tissue from exterior thereof. The parameters of the tissue are then measured periodically along a line extending from the entry point and moving away therefrom. A determination is then made if at least one boundary between tissue types has occurred during the measurement process. The measurements along the line are then compared to a predetermined map of the tissue boundaries. Thereafter, a point on the map is then selected corresponding to the desired location within the tissue when the measured parameters indicate that the measurements are taking place in proximity thereto.Type: ApplicationFiled: May 3, 2001Publication date: April 18, 2002Inventors: Cole Giller, Hanli Liu
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Patent number: 5782755Abstract: A scheme for monitoring one or more solutes in a biological system comprising the steps of: delivering light into a biological system containing one or more solutes, the light having a wavelength selected to be in a range wherein at least one of the one or more solutes is substantially non-absorbing; detecting at least first and second portions of the delivered light, the first portion having traveled through the biological system along one or more paths characterized by a first average path length, and the second portion having traveled through the biological system along one or more paths characterized by a second average path length that is greater than the first average path length; and comparing the first and second portions of the delivered light to monitor a concentration of one or more of the solutes in the biological system.Type: GrantFiled: December 2, 1994Date of Patent: July 21, 1998Assignee: Non-Invasive Technology, Inc.Inventors: Britton Chance, Hanli Liu
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Patent number: D1022473Type: GrantFiled: December 8, 2023Date of Patent: April 16, 2024Inventor: Hanli Liu