Patents by Inventor Hannes Link

Hannes Link has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for enhancing N-acetylglucosamine production through glcK knockout of
    Patent number: 9914949
    Abstract: The present invention provides a method for enhancing N-acetylglucosamine production by usage of a recombinant Bacillus subtilis with a glcK knockout. This invention enhanced the production of GlcNAc by knocking out the glcK gene which encodes a glucokinase, thus eliminating the GlcNAc phosphorylation to GlcNAc-6-P. The specific growth rate and content of GlcNAc in the supernatant of the recombinant Bacillus subtilis with the glcK knockout were 0.15 h?1 and 3.0 g/L, respectively, which were 2.32 times and 2.14 times of those of the control strain without glcK knockout. The recombinant Bacillus subtilis of the present invention would be potentially useful for industrial production of GlcNAc.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: March 13, 2018
    Assignee: Jiangnan University
    Inventors: Long Liu, Jian Chen, Guocheng Du, Jianghua Li, Yanfeng Liu, Hannes Link, Uwe Sauer
  • Method for Enhancing N-acetylglucosamine Production through glcK Knockout of Bacillus subtilis
    Publication number: 20170009267
    Abstract: The present invention provides a method for enhancing N-acetylglucosamine production by usage of a recombinant Bacillus subtilis with a glcK knockout. This invention enhanced the production of GlcNAc by knocking out the glcK gene which encodes a glucokinase, thus eliminating the GlcNAc phosphorylation to GlcNAc-6-P. The specific growth rate and content of GlcNAc in the supernatant of the recombinant Bacillus subtilis with the glcK knockout were 0.15 h?1 and 3.0 g/L, respectively, which were 2.32 times and 2.14 times of those of the control strain without glcK knockout. The recombinant Bacillus subtilis of the present invention would be potentially useful for industrial production of GlcNAc.
    Type: Application
    Filed: November 6, 2015
    Publication date: January 12, 2017
    Applicant: Jiangnan University
    Inventors: Long Liu, Jian Chen, Guocheng Du, Jianghua Li, Yanfeng Liu, Hannes Link, Uwe Sauer