Abstract: Disclosed herein are (6-(2H-indazol-5-yl)pyridazin-3-yl)octahydrocyclopenta[c]pyrrol-5-amine compounds, useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.

Abstract: Disclosed herein are substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.

Abstract: Method and compositions for prophylaxis and/or treatment of diseases of the eye using antagonists of the integin receptors ?v?3 and/or ?v?5. The compositions can be nanoparticles and are administered to the eye by injection into the subTenon's space of the eye.

Abstract: A method and mechanism for the magnetic separation of material from a fluid containing magnetic and non-magnetic material, passing the fluid through matrix containing canisters wherein the canisters are carried on a turret which moves axially and rotatably. In four quadrilaterally arranged locations, two canisters are supported in a separation position within coils until they are filled and then are moved axially and rotationally to cleansing stations while cleansed canisters are rotated and moved axially up into the separation stations. A distribution head connects to the turret for delivery of magnetic material containing fluid and cleansing fluid.

Abstract: A casting consisting of a dehydrated agglomerate of particulate material and shaped such that one of its right angle projections is in the form of a trapezoid whose sides include angles greater than 90.degree., the sides being joined by means of curved surfaces.

Abstract: The invention relates to a throttling valve with low noise. The passage of fluid is controlled by an aperture between parallel discs, which can be turned around special axes for altering the distance between them.

Abstract: A method and apparatus are disclosed for cleansing a matrix of a magnetic separator and more particularly a wet-magnetic separator having adherent magnetic material. The matrix is cleansed both with a liquid medium and an additional gaseous compressible medium. The introduction of the compressible medium is controlled in accordance with a measure of the adherent magnetic material present.

Abstract: A method for reducing the sulfur content of coal which involves an integrated, continuous process including the steps of grinding the coal in a dry state, activating the ground coal to increase substantially the magnetic susceptibility of the pyrite contained therein, and separating the thus activated pyrite magnetically from the remainder of the coal.

Abstract: A method and apparatus is disclosed for cleaning magnetic material attracted to a ferromagnetic matrix within a separating chamber of a magnetic separator. The magnetic material retained by the matrix is cleaned in a high pressure cleaning stage in which both a liquid medium and a gaseous medium are provided under pressure to clean the magnetic material. As the gaseous medium passes through the matrix, it does so with a pressure drop which is substantially lower than that of the liquid passing through the matrix. Consequently, as the gaseous medium expands, it transfers a portion of its kinetic energy to the liquid which provides improved and more rapid cleaning effects than known rinsing steps.

Abstract: The invention relates to a control valve for throttling in which is provided simple structural elements in the outlet section for having a low noise characteristic.

Abstract: A high intensity magnetic field separator for the wet preparation of magnetizable particles of solids receives a charging material having a carrier medium with the particles therein through an arrangement of ferromagnetic bodies, organized as a matrix, in the area of a magnetic field. A hollow body of magnetically inert material is rotatably mounted for rotation about a vertical axis and carries a ferromagnetic body on its outer side and rotates in close proximity about at least one magnetic system which fixedly mounted within the interior of the rotating body. The hollow body is at least approximately rotationally symmetrical and is preferably a cylinder, but may take the shape of a truncated cone or a polygon. The magnetic system comprises an arrangement of superconducting coils in a cryostat which has refrigeration conduits extending down through the open of the hollow body and downwardly through the base of the machine which mounts the hollow body.

Abstract: Magnetizable particles are separated from a sludge which includes fine-grained particles and the magnetizable particles suspended in a carrier by creating a laminar flow of the sludge over a surface which is disposed at an angle to the horizontal. The surface is included in a magnetic system which has a plurality of supra-conducting magnets with coils which are energizable to provide alternate north and south poles longitudinally and transversely of the surface. The supra-conducting magnets each have an end adjacent the surface and short-circuited opposite ends to amplify the magnetic force in the direction of the surface.