Abstract: The present invention relates to the use of specific compounds for the treatment and/or prophylaxis of inflammatory conditions. Furthermore, the present invention relates to the use of inhibitors for treating viral infections, particularly to the use of MEK inhibitors, especially MEKI inhibitors, for prophylaxis and/or treatment of virally induced hemorrhagic fever and/or hemorrhagic shock syndromes, for the treatment of virally induced TNF-∝ mediated diseases, and for regulating and/or inhibiting of virally induced TNF-∝ production. Furthermore, methods for preventing and/or treating of virally induced hemonrhagic fevers and/or hemorrhagic shock syndromes, for regulating and/or inhibiting virally induced TNF-∝ production, and for the treatment of virally induced TNF-÷ medicated diseases are disclosed together with pharmaccutical compositions useful within said methods.

Abstract: Target cell-specific, non-viral vectors for inserting genes into cells, pharmaceuticals composition comprising such vectors, and methods of their use. Target cell-specific, non-viral vectors for inserting at least one gene into cells of an organism, comprising a complex comprising the following components: a) a non-viral carrier for the gene to be inserted, b) a ligand which can bind specifically to the desired target cell, c) a fusion protein for the penetration of the vector into the cytoplasm of the target cell, and d) the gene to be introduced are disclosed. Vectors of this nature are used, for example, in gene therapy.

Abstract: Target cell-specific, non-viral vectors for inserting genes into cells, pharmaceuticals composition comprising such vectors, and methods of their use. Target cell-specific, non-viral vectors for inserting at least one gene into cells of an organism, comprising a complex comprising the following components:a) a non-viral carrier for the gene to be inserted,b) a ligand which can bind specifically to the desired target cell,c) a fusion protein for the penetration of the vector into the cytoplasm of the target cell, andd) the gene to be introducedare disclosed. Vectors of this nature are used, for example, in gene therapy.