Patents by Inventor Hans Dieter Orth

Hans Dieter Orth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and agent for the immunological determination of enzymes
    Patent number: 4366242
    Abstract: A process for the quantitative immunological determination of an enzyme in a liquid, comprises incubating anti-enzyme antibodies which are adsorbed on a water-insoluble carrier, with the sample solution containing the enzyme, whereby the enzyme bonds to the antibodies but retains a reproducible proportion of its activity in its complex with the antibodies; removing the sample solution; washing the antibody carrier, which is charged with enzyme; and determining the activity of the enzyme bonded to the antibodies.
    Type: Grant
    Filed: December 29, 1980
    Date of Patent: December 28, 1982
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Siegfried Neumann, Norbert Hennrich, Hans-Dieter Orth, Gerhard Pfleiderer, Evangelista Jockers-Wretou, Hans Pauly
  • Antibodies against creatinekinase-M8 and process for the production thereof
    Patent number: 4237044
    Abstract: Antibodies against the M subunit of CK isoenzymes having a molecular weight between about 130,000 and 210,000, and inhibiting the enzymatic activity of the M subunit, optionally also in the presence of CK substrates, without inactivating the enzymatic activity of the B subunit of any CK-MB which may be present, are described. A process for the production of these antibodies comprises inoculating animals with activated CK-MM and recovering the antibodies in a conventional manner.
    Type: Grant
    Filed: May 8, 1979
    Date of Patent: December 2, 1980
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Uwe Wurzburg, Norbert Hennrich, Hans-Dieter Orth, Hermann Lang
  • Process and composition for determining the activity of creatinekinase-MB
    Patent number: 4067775
    Abstract: A process for determination of CK-MB activity in a sample of a body fluid comprising the steps of incubating the sample, optionally in the presence of CK substrates, with antibodies which inhibit enzymatic activity of the M subunit in CK isoenzymes MM and MB without inactivating enzymatic activity of the B subunit in any CK-MB which may be present and determining the activity of the CK B subunit in the resultant sample.
    Type: Grant
    Filed: November 1, 1976
    Date of Patent: January 10, 1978
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Uwe Wurzburg, Norbert Hennrich, Hans-Dieter Orth, Hermann Lang
  • Analysis of isoenzyme patterns
    Patent number: 4012285
    Abstract: Isoenzyme patterns of an enzyme in biological fluids, extracts, and/or excretions are quantitatively determined by precipitating at least 90% of an isoenzyme antigen with a corresponding heterologous antiserum and comparing the remaining enzyme activity with the total activity with the use of a conventional agent for enzyme activity determination.
    Type: Grant
    Filed: November 27, 1973
    Date of Patent: March 15, 1977
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Gerhard Pfleiderer, Hermann Lang, Norbert Hennrich, Hans Dieter Orth
  • Carrier matrix for the fixation of biochemically effective substances and process for the preparation thereof
    Patent number: 3959080
    Abstract: Biochemically active compounds e.g., proteins and particulate biological materials such as bacteria and viruses, are immobilized on a water-swellable or water-insoluble matrix by covalent bonding to a partially crosslinked polymer containing reactive groups capable of binding the biochemically active compound thereto.
    Type: Grant
    Filed: September 26, 1973
    Date of Patent: May 25, 1976
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Hans Dieter Orth, Wolfgang Brummer, Michael Klockow, Norbert Hennrich