Patents by Inventor Hans-Frieder Kuehnle

Hans-Frieder Kuehnle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6441185
    Abstract: Improved process of compounds of formula III in which A denotes CH═CH or S W denotes O X denotes S, O or NR2 in which the residue R2 is hydrogen or C1-C6 alkyl, Y denotes CH or N R denotes naphthyl, thienyl or phenyl which is optionally monosubstituted or disubstituted with C1-C3 alkyl, CF3, C1-C3 alkoxy, F, Cl or bromine, R1 denotes hydrogen or C1-C6 alkyl and n denotes 1-3 by reducing a compound of the general formula IV, in which A, W, X, Y, R, R1 and n have the meanings stated above with activated aluminum in a protic solvent, as well as new compounds of formula III and pharmaceutical preparations containing these compounds.
    Type: Grant
    Filed: February 14, 2001
    Date of Patent: August 27, 2002
    Assignee: Roche Diagnostics GmbH
    Inventors: Hans-Frieder Kühnle, Ernst-Christian Witte, Hans-Peter Wolff
  • Patent number: 6258832
    Abstract: Improved process of compound of formula III in which A denotes CH═CH or S W denotes O X denotes S, O or NR2 in which the residue R2 is hydrogen or C1-C6 alkyl, Y denotes CH or N R denotes naphthyl, thienyl or phenyl which is optionally monosubstituted or disubstituted with C1-C3 alkyl, CF3, C1-C3 alkoxy, F, Cl or bromine, R1 denotes hydrogen or C1-C6 alkyl and n denotes 1-3 by reducing a compound of the general formula IV, in which A, W, X, Y, R, R1 and n have the meanings stated above with activated aluminium in a protic solvent, as well as new compounds of formula III and pharmaceutical preparations containing these compounds.
    Type: Grant
    Filed: September 14, 1999
    Date of Patent: July 10, 2001
    Assignee: Roche Diagnostics GmbH
    Inventors: Hans-Frieder Kühnle, Ernst-Christian Witte, Hans-Peter Wolff
  • Patent number: 5145611
    Abstract: Carboxylic acid derivatives of the formula ##STR1## R.sub.1 is alkoxy, alkylthio, alkylsulphinyl, alkulsulphonyl, alkylamino, cycloalkyl, or cycloalkoxy or optionally substituted aryl, aryloxy, arylthio, arylsulphinyl, arylsulphonyl or arylamino. R.sub.2 is optionally substituted aryl or, when B is alkylene also a hydrogen atom. A is a straight-chained or branched, saturated or unsaturated alkylene containing 3 to 10 carbon atoms which is optionally interrupted by a heteratom attached to a saturated carbon and has a chain length of at least 3 atoms. Y is S(O).sub.n group or oxygen, n being 0, 1 or 2. B is a valency bond or a straight-chained or branched, saturated or unsaturated alkylene containing 1 to 18 carbon atoms. Physiologically acceptable salts, esters and amides thereof are also included. The compounds are useful in the treatment of metabolic diseases.
    Type: Grant
    Filed: January 12, 1988
    Date of Patent: September 8, 1992
    Assignee: Boehringer Mannheim GmbH
    Inventors: Hans P. Wolff, Ernst-Christian Witte, Hans-Frieder Kuehnle