Patents by Inventor Hans-Georg Lerchen

Hans-Georg Lerchen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PRODRUGS AND THE USE THEREOF
    Publication number: 20120122820
    Abstract: The present application relates to prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.
    Type: Application
    Filed: July 23, 2008
    Publication date: May 17, 2012
    Inventors: Nicole Diedrichs, Thomas Krahn, Ursula Krenz, Jörg Keldenich, Hanna Tinel, Claudia Hirth-Dietrich, Hans-Georg Lerchen
  • AMINOACYL PRODRUG DERIVATIVES AND MEDICAMENTS FOR THE TREATMENT OF THROMBOEMBOLITIC DISORDERS
    Publication number: 20120088761
    Abstract: The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
    Type: Application
    Filed: December 16, 2011
    Publication date: April 12, 2012
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Hans-Georg Lerchen, Ursula Krenz, Karl-Heinz Schlemmer, Elisabeth Perzborn, Jörg Keldenich
  • Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension
    Publication number: 20120058983
    Abstract: The present invention relates to the use of selective adenosine A1 agonists, in particular the dicyanopyridines of formula (I), for the treatment and/or prophylaxis of glaucoma and ocular hypertension as well as the their use for the production of a medicament for the treatment and/or prophylaxis of glaucoma and ocular hypertension.
    Type: Application
    Filed: August 16, 2011
    Publication date: March 8, 2012
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Jürgen Klar, Georges VON DEGENFELD, Hans-Georg LERCHEN, Barbara Albrecht-Küpper, Andreas KNORR, Peter SANDNER, Daniel MEIBOM
  • Aminoacyl prodrug derivatives and medicaments for the treatment of thromboembolitic disorders
    Patent number: 8101601
    Abstract: The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-morpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
    Type: Grant
    Filed: February 6, 2007
    Date of Patent: January 24, 2012
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Hans-Georg Lerchen, Ursula Krenz, Karl-Heinz Schlemmer, Elisabeth Perzborn, Joerg Keldenich
  • DIPEPTOID PRODRUGS AND THE USE THEREOF
    Publication number: 20110294718
    Abstract: The present application relates to prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.
    Type: Application
    Filed: July 23, 2008
    Publication date: December 1, 2011
    Inventors: Hans-Georg Lerchen, Ursula Krenz, Joerg Keldenich, Nicole Diedrichs, Thomas Krahn, Claudia Hirth-Dietrich, Barbara Albrecht-Küpper
  • DIPEPTOID PRODRUGS AND THE USE THEREOF
    Publication number: 20110294719
    Abstract: The present application relates to dipeptide-like prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-4-(4-{[2,3-dihydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.
    Type: Application
    Filed: December 3, 2009
    Publication date: December 1, 2011
    Inventors: Hans-Georg Lerchen, Daniel Meibom, Alexandros Vakalopoulos, Barbara Albrecht-Küpper, Joerg Keldenich, Katja Zimmermann, Peter Nell, Ursula Krenz
  • AMINO ACID ESTER PRODRUGS AND THE USE THEREOF
    Publication number: 20110237629
    Abstract: The present application relates to amino acid ester prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-4-(4-{[2,3-dihydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitriles, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.
    Type: Application
    Filed: December 3, 2009
    Publication date: September 29, 2011
    Applicant: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Daniel Meibom, Hans-Georg Lerchen, Alexandros Vakalopoulos, Barbara Albrech-Küpper, Peter Nell, Jörg Keldenich, Katja Zimmermann, Ursula Krenz
  • AMINOACYL PRODRUGS AS AN ACTIVE PHARMACEUTICAL INGREDIENT FOR THROMBOEMBOLIC DISORDERS
    Publication number: 20110172232
    Abstract: The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
    Type: Application
    Filed: June 28, 2008
    Publication date: July 14, 2011
    Applicant: Bayers Schering Pharma Aktiengesellschaft
    Inventors: Hans-Georg Lerchen, Ursula Krenz, Michael Härter, Mark Jean Gnoth, Georges Von Degenfeld, Elke Dittrich-Wengenroth, Anja Buchmüller, Susanne Röhrig, Swen Allerheiligen, Elisabeth Perzborn, Christoph Gerdes, Karl-Heinz Schlemmer, Metin Akbaba
  • Aminoacyl Prodrug Derivatives and Medicaments for the Treatment of Thromboembolitic Disorders
    Publication number: 20110034453
    Abstract: The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
    Type: Application
    Filed: February 6, 2007
    Publication date: February 10, 2011
    Inventors: Hans-Georg Lerchen, Ursula Krenz, Karl-Heinz Schlemmer, Elisabeth Perzborn, Joerg Keldenich
  • Aminoacyl prodrug derivatives and medicaments for treatment of thromboembolic disorders
    Publication number: 20100292230
    Abstract: The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
    Type: Application
    Filed: August 23, 2007
    Publication date: November 18, 2010
    Applicant: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Hans-Georg Lerchen, Ursula Krenz, Karl-Heinz Schlemmer, Elisabeth Perzborn
  • AMINOACYL PRODRUGS
    Publication number: 20100273789
    Abstract: The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
    Type: Application
    Filed: June 28, 2008
    Publication date: October 28, 2010
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Hans-Georg Lerchen, Ursula Krenz, Michael Härter, Mark Jean Gnoth, Georges Von Degenfeld, Elke Dittrich-Wengenroth, Anja Buchmüller, Susanne Röhrig, Swen Allerheiligen, Elisabeth Perzborn, Christoph Gerdes, Karl-Heinz Schlemmer, Metin Akbaba
  • ALKYLAMINO-SUBSTITUTED DICYANOPYRIDINES AND THEIR AMINO ACID ESTER PRODRUGS
    Publication number: 20100197609
    Abstract: The present application relates to novel 6-alkylamino-substituted dicyanopyridines, to their amino acid ester prodrugs, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
    Type: Application
    Filed: January 29, 2010
    Publication date: August 5, 2010
    Applicant: BAYER SCHERING PHARMA
    Inventors: Alexandros VAKALOPOULOS, Daniel MEIBOM, Barbara ALBRECHT-KÜPPER, Katja ZIMMERMANN, Jörg KELDENICH, Hans-Georg LERCHEN, Peter NELL, Frank SÜSSMEIER, Ursula KRENZ
  • BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF CANCERS OF THE CENTRAL NERVOUS SYSTEM
    Publication number: 20100125073
    Abstract: The present invention relates to benzofuran and benzothiophene derivatives and compositions containing such compounds for the production of medicaments for the treatment of cancers of the central nervous system as monotherapy or combination with other agents.
    Type: Application
    Filed: August 28, 2007
    Publication date: May 20, 2010
    Inventors: Olaf Weber, Verena Voehringer, Hans-Georg Lerchen, Frank-Thorsten Hafner, Joerg Keldenich, Karl-Heinz Schlemmer, Ursula Krenz, Bernd Riedl
  • Novel cytostatic conjugates with integrin ligands
    Publication number: 20080108576
    Abstract: The present invention relates to cytostatics which have a tumour-specific action as a result of linkage to ?v?3 integrin antagonists via preferred linking units which can be selectively cleaved by elastase, i.e. by an enzyme which can especially be found in tumour tissue. The preferred linking units provide sufficient stability of the conjugate of cytostatic and ?v?3 integrin antagonist in biological fluids and, at the same time, the desired intracellular action within tumour cells as a result of its specific enzymatic or hydrolytic cleavability with release of the cytostatic.
    Type: Application
    Filed: December 4, 2007
    Publication date: May 8, 2008
    Applicant: Bayer Aktiengesellschaft
    Inventors: Hans-Georg Lerchen, Jorg Baumgarten, Andreas Schoop, Markus Albers
  • Cytostatic conjugates with integrin ligands
    Patent number: 7304037
    Abstract: The present invention relates to cytostatics which have a tumor-specific action as a result of linkage to ?v?3 integrin antagonists via preferred linking units which can be selectively cleaved by elastase, i.e. by an enzyme which can especially be found in tumor tissue. The preferred linking units provide sufficient stability of the conjugate of cytostatic and ?v?3 integrin antagonist in biological fluids and, at the same time, the desired intracellular action within tumor cells as a result of its specific enzymatic or hydrolytic cleavability with release of the cytostatic.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: December 4, 2007
    Assignee: Bayer Akiengesellschaft
    Inventors: Hans-Georg Lerchen, Jörg Baumgarten, Andreas Schoop, Markus Albers
  • Integrin-mediated drug targeting
    Patent number: 7220824
    Abstract: The present invention relates to cytostatics which have a tumour-specific action as a result of linkage to ?v?3 integrin antagonists via preferred linking units. The preferred linking units guarantee serum stability of the conjugate of cytostatic and ?v?3 integrin antagonist and at the same time the desired intracellular action in tumour cells as a result of their enzymatic or hydrolytic cleavability with release of the cytostatic.
    Type: Grant
    Filed: August 28, 2000
    Date of Patent: May 22, 2007
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hans-Georg Lerchen, Jörg Baumgarten, Ulf Brüggemeier, Markus Albers, Andreas Schoop, Thomas-J. Schulze
  • Isotopically coded affinity markers 3
    Patent number: 7132295
    Abstract: This application relates to isotopically labeled affinity markers of the formula (II) for mass spectrometric analysis of proteins. In formula (II), the groups A, PRG, S, Z, L', Z', R, R', k, l, m, and n are as defined in the claims. The application also provides a process for preparing these materials, a method for analyzing proteins using such materials, and a kit containing one or more of these materials.
    Type: Grant
    Filed: October 30, 2002
    Date of Patent: November 7, 2006
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hans-Georg Lerchen, Hans-Ulrich Siegmund, Dorian Immler, Andreas Schumacher, Daniel Auriel
  • Integrin-Mediated drug targeting
    Publication number: 20060189544
    Abstract: The present invention relates to cytostatics which have a tumour-specific action as a result of linkage to ?v?3 integrin antagonists via preferred linking units. The preferred linking units guarantee serum stability of the conjugate of cytostatic and ?v?3 integrin antagonist and at the same time the desired intracellular action in tumour cells as a result of their enzymatic or hydrolytic cleavability with release of the cytostatic.
    Type: Application
    Filed: April 7, 2006
    Publication date: August 24, 2006
    Applicant: Bayer Aktiengesellschaft
    Inventors: Hans-Georg Lerchen, Jorg Baumgarten, Ulf Bruggemeier, Markus Albers, Andreas Schoop, Thomas Schulze
  • Isotope-coded affinity tag
    Publication number: 20050069961
    Abstract: The invention relates to novel isotope-coded affinity tags for use in mass-spectrometric analysis of proteins. The invention also relates to the production and use of these novel tags.
    Type: Application
    Filed: October 28, 2002
    Publication date: March 31, 2005
    Inventors: Oswald Lockoff, Thomas Lehmann, Hans-Georg Lerchen, Dorian Immler, Hans-Ulrich Siegmund
  • Isotopically coded affinity markers 3
    Publication number: 20050049406
    Abstract: The invention concerns isotopically coded affinity markers (ICAT) for mass spectrometric analysis of proteins, and the preparation and use if said markers.
    Type: Application
    Filed: October 30, 2002
    Publication date: March 3, 2005
    Inventors: Hans-Georg Lerchen, Hans-Ulrich Siegmund, Dorian Immler, Andreas Schumacher, Daniel Auriel