Patents by Inventor Hans-Heinrich Hörl

Hans-Heinrich Hörl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11224843
    Abstract: The present invention relates to a crosslinked unreinforced cellulose hydrate membrane crosslinked using at least two different crosslinking agents, to a method for the production thereof and to the use of the crosslinked unreinforced cellulose hydrate membrane according to the invention.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: January 18, 2022
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Sandra Van Der Kruijs, Annette Reiche, Gabriel Nino-Amézquita, Louis Villain, Hans-Heinrich Hörl, Dieter Melzner, Franziska Bäthe
  • Publication number: 20200230557
    Abstract: The present invention relates to a crosslinked unreinforced cellulose hydrate membrane crosslinked using at least two different crosslinking agents, to a method for the production thereof and to the use of the crosslinked unreinforced cellulose hydrate membrane according to the invention.
    Type: Application
    Filed: December 1, 2017
    Publication date: July 23, 2020
    Inventors: Sandra Van Der Kruijs, Annette Reiche, Gabriel Nino-Amézquita, Louis Villain, Hans-Heinrich Hörl, Dieter Melzner, Franziska Bäthe
  • Patent number: 10253299
    Abstract: The present invention relates to a sulfated cellulose hydrate membrane, a method for the preparation thereof and the use of the membrane as adsorption membrane for the purification of viruses.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: April 9, 2019
    Assignee: Sartorius Stedium Biotech GMBH
    Inventors: Louis Villain, Hans-Heinrich Hörl, Christian Brumm
  • Patent number: 10100294
    Abstract: The present invention relates to a process for the separation of a mixture of a protein and its reaction product with a polyalkylene glycol, comprising the steps: a) providing a mixture comprising the protein and the reaction product in a fluid, b) bringing the mixture of step a) into contact with a microporous cellulose acetate membrane with adsorption of the reaction product onto the cellulose acetate membrane, the protein not becoming adsorbed onto the cellulose acetate membrane, c) removal of the protein from the cellulose acetate membrane, and d) desorbing the reaction product from the cellulose acetate membrane, the reaction product being selected from the group comprising the protein which is mono- or polyfunctionalized by the polyalkylene glycol, or mixtures thereof.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: October 16, 2018
    Assignee: SARTORIUS STEDIM BIOTECH GMBH
    Inventors: Wolfgang Demmer, Louis Villain, Hans-Heinrich Hoerl
  • Publication number: 20160257941
    Abstract: The present invention relates to a sulfated cellulose hydrate membrane, a method for the preparation thereof and the use of the membrane as adsorption membrane for the purification of viruses.
    Type: Application
    Filed: September 11, 2014
    Publication date: September 8, 2016
    Inventors: Louis Villain, Hans-Heinrich Hörl, Christian Brumm
  • Patent number: 9433904
    Abstract: There is provided a cellulose hydrate membrane having a porous double structure which consists of micropores having a diameter in the range from >100 nm to 20 ?m and ultrapores which have a diameter of <100 nm and which are not accessible to Blue Dextran having an average molecular weight Mw of 2 000 000, wherein the fraction of the volume of the ultrapores is more than 15% of the entire pore volume accessible to water. In addition, a method for producing the membrane, its use as an adsorption membrane, and an apparatus for membrane chromatography are specified.
    Type: Grant
    Filed: February 10, 2009
    Date of Patent: September 6, 2016
    Assignee: SARTORIUS STEDIM BIOTECH GMBH
    Inventors: Wolfgang Demmer, René Faber, Hans-Heinrich Hörl, Csilla Kiss, Dietmar Nuβbaumer
  • Patent number: 9375658
    Abstract: A porous, non-particulate, convectively permeable polysaccharide matrix has a surface on which there is fixed a grafted-on polymer derived from at least one ethylenic monomer compound having functional groups, wherein the polysaccharide matrix is prepared by grafting a porous, non-particulate, convectively permeable polysaccharide starting matrix with the at least one ethylenic monomer compound in the presence of an organic acid having at least one carboxylic acid group and/or at least one acidic XH group, where X=—O, —S, or —N, and of a transition metal or lanthanide compound. The polysaccharide matrix has a high protein binding capacity. A process for preparing the polysaccharide matrix and a method for using the polysaccharide matrix for material separation also are provided.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: June 28, 2016
    Assignee: SARTORIUS STEDIM BIOTECH GMBH
    Inventors: Hans-Heinrich Hoerl, Wolfgang Demmer, Rene Faber, Christian Brumm
  • Publication number: 20150140637
    Abstract: The present invention relates to a process for the separation of a mixture of a protein and its reaction product with a polyalkylene glycol, comprising the steps: a) providing a mixture comprising the protein and the reaction product in a fluid, b) bringing the mixture of step a) into contact with a microporous cellulose acetate membrane with adsorption of the reaction product onto the cellulose acetate membrane, the protein not becoming adsorbed onto the cellulose acetate membrane, c) removal of the protein from the cellulose acetate membrane, and d) desorbing the reaction product from the cellulose acetate membrane, the reaction product being selected from the group comprising the protein which is mono- or polyfunctionalized by the polyalkylene glycol, or mixtures thereof.
    Type: Application
    Filed: March 21, 2012
    Publication date: May 21, 2015
    Inventors: Wolfgang Demmer, Louis Villain, Hans-Heinrich Hoerl
  • Patent number: 8969094
    Abstract: The present invention relates to a method for the validation of a non-particulate ion exchange adsorber and a kit for the validation of a non-particulate ion exchange adsorber.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: March 3, 2015
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Wolfgang Demmer, Rene Faber, Hans-Heinrich Hoerl, Axel Thiefes
  • Patent number: 8557304
    Abstract: The present invention relates to a method of isolating phenolic secondary plant constituents from plant material using a microporous membrane which displays affinity ligands for the phenolic secondary plant constituents.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: October 15, 2013
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Hans-Heinrich Hoerl, Wolfgang Demmer, Rene Faber
  • Patent number: 8343350
    Abstract: The invention comprises a membrane and device and method for removing proteases from fluids, particularly from biological fluids and pharmaceutical solutions, which uses a microporous membrane body, whereby inhibitors that selectively bind proteases are coupled to the membrane body by chemically activated groups.
    Type: Grant
    Filed: June 17, 2003
    Date of Patent: January 1, 2013
    Assignee: Sartorius AG
    Inventors: Wolfgang Demmer, Dietmar Nussbaumer, Hans-Heinrich Hörl
  • Patent number: 8343351
    Abstract: The invention comprises a membrane and device and method for removing proteases from fluids, particularly from biological fluids and pharmaceutical solutions, which uses a microporous membrane body, whereby inhibitors that selectively bind proteases are coupled to the membrane body by chemically activated groups.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: January 1, 2013
    Assignee: Sartorius AG
    Inventors: Wolfgang Demmer, Dietmar Nussbaumer, Hans-Heinrich Hörl
  • Publication number: 20120276652
    Abstract: The present invention relates to a method for the validation of a non-particulate ion exchange adsorber and a kit for the validation of a non-particulate ion exchange adsorber.
    Type: Application
    Filed: November 10, 2010
    Publication date: November 1, 2012
    Applicant: SARTORIUS STEDIM BIOTECH GMBH
    Inventors: Wolfgang Demmer, Rene Faber, Hans-Heinrich Hoerl, Axel Thiefes
  • Publication number: 20120264221
    Abstract: The present invention relates to a method for the validation of a non-particulate adsorbent by secondary reaction and a kit for the validation of a non-particulate adsorbent by secondary reaction.
    Type: Application
    Filed: November 10, 2010
    Publication date: October 18, 2012
    Applicant: SARTORIUS STEDIM BIOTECH GMBH
    Inventors: Wolfgang Demmer, Rene Faber, Hans-Heinrich Hoerl, Axel Thiefes
  • Publication number: 20120074068
    Abstract: A porous, non-particulate, convectively permeable polysaccharide matrix has a surface on which there is fixed a grafted-on polymer derived from at least one ethylenic monomer compound having functional groups, wherein the polysaccharide matrix is prepared by grafting a porous, non-particulate, convectively permeable polysaccharide starting matrix with the at least one ethylenic monomer compound in the presence of an organic acid having at least one carboxylic acid group and/or at least one acidic XH group, where X=—O, —S, or —N, and of a transition metal or lanthanide compound. The polysaccharide matrix has a high protein binding capacity. A process for preparing the polysaccharide matrix and a method for using the polysaccharide matrix for material separation also are provided.
    Type: Application
    Filed: April 23, 2010
    Publication date: March 29, 2012
    Applicant: SARTORIUS STEDIM BIOTECH GMBH
    Inventors: Hans-Heinrich Hoerl, Wolfgang Demmer, Rene Faber, Christian Brumm
  • Publication number: 20120077994
    Abstract: The present invention relates to a method of isolating phenolic secondary plant constituents from plant material using a microporous membrane which displays affinity ligands for the phenolic secondary plant constituents.
    Type: Application
    Filed: April 23, 2010
    Publication date: March 29, 2012
    Applicant: SARTORIUS STEDIM BIOTECH GMBH
    Inventors: Hans-Heinrich Hoerl, Wolfgang Demmer, Rene Faber
  • Publication number: 20110147292
    Abstract: There is provided a cellulose hydrate membrane having a porous double structure which consists of micropores having a diameter in the range from >100 nm to 20 ?m and ultrapores which have a diameter of <100 nm and which are not accessible to Blue Dextran having an average molecular weight Mw of 2 000 000, wherein the fraction of the volume of the ultrapores is more than 15% of the entire pore volume accessible to water. In addition, a method for producing the membrane, its use as an adsorption membrane, and an apparatus for membrane chromatography are specified.
    Type: Application
    Filed: February 10, 2009
    Publication date: June 23, 2011
    Applicant: SARTORIUS STEDIM BIOTECH GMBH
    Inventors: Wolfgang Demmer, René Faber, Hans-Heinrich Hörl, Csilla Kiss, Dietmar Nußbaumer
  • Patent number: 7422686
    Abstract: There is disclosed a process for the production of cellulose hydrate ultrafiltration membranes having improved filtration performance and the ultrafiltration membranes produced by the process.
    Type: Grant
    Filed: November 1, 2005
    Date of Patent: September 9, 2008
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Dietmar Nussbaumer, Hans-Heinrich Hörl
  • Patent number: 6294090
    Abstract: An adsorptive separation device is disclosed having at least one spiral wound adsorption membrane situated around the periphery of a core mandrel wherein the flow is radial from a feed plenum situated between the core mandrel and the membrane, through the membrane to a permeate plenum located between the membrane and a housing for both the core mandrel and the spiral wound membrane. An array of such separation devices is also disclosed showing connections in parallel, in series, in both parallel and in series and in tandem.
    Type: Grant
    Filed: September 16, 1999
    Date of Patent: September 25, 2001
    Assignee: Sartorius AG
    Inventors: Dietmar Nussbaumer, Khoung To Vinh, Abdul Weiss, Wolfgang Demmer, Hans-Heinrich Hörl, Andreas Graus, Günter Pradel