Patents by Inventor Hans-Joachim Kolb

Hans-Joachim Kolb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8012470
    Abstract: According to the invention there is described a method for ex vivo immunization of humans and animals comprising the following steps of: a) isolating autologous tumor cells; b) treating the tumor cells to prevent the survival thereof following reinfusion; c) incubating the thus treated tumor cells with intact heterologous bispecific and/or trisepcific antibodies showing the following properties: ?—binding to a T cell; ?—binding to at least one antigen on a tumor cell; ?—binding, by their Fc portion (in the case of bispecific antibodies), or by a third specificity (in the case of trispecific antibodies) to Fc receptor-positive cells.
    Type: Grant
    Filed: July 20, 2005
    Date of Patent: September 6, 2011
    Assignee: Helmholtz Zentrum Munchen Deutsches Forschungszentrum fur Gesundheit und Umwelt (GmbH)
    Inventors: Horst Lindhofer, Hans-Joachim Kolb, Reinhard Zeidler, Georg Bornkamm
  • Patent number: 7233435
    Abstract: The present invention concerns a microscope 1. The microscope 1 encompasses a microscope stand 2, an objective 4 having an optical axis 5, a microscope stage 6 serving to receive a specimen 7, and a focusing device 20 serving to focus the specimen 7. With the focusing device 20, the objective or the microscope stage 6 is positionable relative to the microscope stand 2 in the direction of the optical axis 5 of the objective 4. The focusing device 20 comprises at least one operating element 8 with which an operator controls the positioning of the objective 4 or of the microscope stage 6. For adaptation of the spatial arrangement of the operating element 8 to the needs of an operator, the microscope 1 according to the present invention is characterized in that the spatial arrangement of the operating element 8 relative to the microscope stand 2 is modifiable.
    Type: Grant
    Filed: August 31, 2004
    Date of Patent: June 19, 2007
    Assignee: Leica Microsystems CMS GmbH
    Inventors: Manfred Gilbert, Gerhard Pfeifer, Hans-Joachim Kolb
  • Patent number: 7018632
    Abstract: According to the invention there is described a method for ex vivo immunization of humans and animals comprising the following steps: a) isolating autologous tumor cells; b) treating the tumor cells to prevent the survival thereof following reinfusion; c) incubating the thus treated tumor cells with intact heterologous bispecific and/or trispecific antibodies showing the following properties: ?—binding to a T cell; ?—binding to at least one antigen on a tumor cell; ?—binding, by their Fc portion (in the case of bispecific antibodies), or by a third specificity (in the case of trispecific antibodies) to Fc receptor-positive cells.
    Type: Grant
    Filed: June 15, 1998
    Date of Patent: March 28, 2006
    Assignee: GSF-Forschungszentrum für Umwelt und Gesundheit GmbH
    Inventors: Horst Lindhofer, Hans-Joachim Kolb, Reinhard Zeidler, Georg Bornkamm
  • Patent number: 7016108
    Abstract: The invention relates to a microscope, whose support consists of a principal transverse section, a foot section and a column section, which are essentially the same width. A supporting element, is provided on both sides of the column section, said element having the same width along its first contact surface as the column section.
    Type: Grant
    Filed: May 14, 2002
    Date of Patent: March 21, 2006
    Assignee: Leica Microsystems Wetzlar GmbH
    Inventors: Hans-Joachim Kolb, Gerhard Pfeifer
  • Publication number: 20050255110
    Abstract: According to the invention there is described a method for ex vivo immunization of humans and animals comprising the following steps of: a) isolating autologous tumour cells; b) treating the tumour cells to prevent the survival thereof following reinfusion; c) incubating the thus treated tumour cells with intact heterologous bispecific and/or trisepcific antibodies showing the following properties: ?—binding to a T cell; ?—binding to at least one antigen on a tumour cell; ?—binding, by their Fc portion (in the case of bispecific antibodies), or by a third specificity (in the case of trispecific antibodies) to Fc receptor-positive cells.
    Type: Application
    Filed: July 20, 2005
    Publication date: November 17, 2005
    Applicant: GSF FORSCHUNGSZENTRUM FOR UMWELT UND GESUNDHEIT GMBH
    Inventors: Horst Lindhofer, Hans-Joachim Kolb, Reinhard Zeidler, Georg Bornkamm
  • Publication number: 20050057799
    Abstract: The present invention concerns a microscope 1. The microscope 1 encompasses a microscope stand 2, an objective 4 having an optical axis 5, a microscope stage 6 serving to receive a specimen 7, and a focusing device 20 serving to focus the specimen 7. With the focusing device 20, the objective or the microscope stage 6 is positionable relative to the microscope stand 2 in the direction of the optical axis 5 of the objective 4. The focusing device 20 comprises at least one operating element 8 with which an operator controls the positioning of the objective 4 or of the microscope stage 6. For adaptation of the spatial arrangement of the operating element 8 to the needs of an operator, the microscope 1 according to the present invention is characterized in that the spatial arrangement of the operating element 8 relative to the microscope stand 2 is modifiable.
    Type: Application
    Filed: August 31, 2004
    Publication date: March 17, 2005
    Applicant: LEICA MICROSYSTEMS WETZLAR GMBH
    Inventors: Manfred Gilbert, Gerhard Pfeifer, Hans-Joachim Kolb
  • Publication number: 20040218264
    Abstract: The invention relates to a microscope (1), whose support consists of a principal transverse section (3), a foot section (5) and a column section (4), which are essentially the same width. A supporting element (16), is provided on both sides of the column section (4), said element having the same width along its first contact surface (8) as the column section (4).
    Type: Application
    Filed: June 10, 2004
    Publication date: November 4, 2004
    Inventors: Hans-Joachim Kolb, Gerhard Pfeifer
  • Publication number: 20020009430
    Abstract: According to the invention there is described a method for ex vivo immunization of humans and animals comprising the following steps of:
    Type: Application
    Filed: June 15, 1998
    Publication date: January 24, 2002
    Inventors: HORST LINDHOFER, HANS-JOACHIM KOLB, REINHARD ZEIDLER, GEORG BORNKAMM