Abstract: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3and R4 are as defined herein.

Abstract: The invention features compounds of formula (I): and pharmaceutically acceptable salts and prodrugs thereof, as well methods for modulating the effects of local and systemic hypoxic events using the compounds.

Abstract: The invention features compounds of formulas I or II: and pharmaceutically acceptable salts and prodrugs thereof, as well methods for modulating the effects of local and systemic hypoxic events using the compounds.

Abstract: The present invention if directed to certain cinnoline compounds that are PDE10 inhibitors, pharmaceutical compounds containing the same and processes for preparing the same. The invention is also directed to methods of treating diseases mediated by PDE10 enzyme such as obesity, non-insulin dependent diabetes, schizophrenia or bipolar disorder, obsessive-compulsive disorder, and the like.

Abstract: PDE4 inhibition is achieved by novel compounds of the Formula I: wherein R1 and R2 are as defined herein.

Abstract: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3and R4 are as defined herein.

Abstract: Methods of treating an inflammatory disorder include administering an effective amount of a compound represented by Structural Formula (I): Ring A is optionally substituted, contains zero, one, two, or three double bonds, and is optionally fused to an aliphatic, aryl or heteroaryl ring; X is an optionally substituted 1 to 3 carbon aliphatic chain that is optionally fused to a monocyclic, optionally substituted, aliphatic, heterocyclic, aryl, or heteroaryl ring, wherein one or two carbons in X are optionally replaced with —O—, —S—, or —NRe—; Y is carbon or nitrogen; R1 and R2 are independently —H, —OH, —CN, —NO2, —NRfRg, halogen, optionally substituted alkyl, or optionally substituted alkoxy; or R1 and R2 together link the carbons to which they are bonded with a bond, —O—, —S—, or —NRh—; R3 and R4 are independently —H, —OH, —CN, —NO2, —NRiRj, halogen, optionally substituted alkyl, or optionally substituted alkoxy, or R4 is ?O; or R3 and R4, taken together with the atoms to which they are bonded, form a

Abstract: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3 and R4 are as defined herein.

Abstract: A microtome comprising a knife holding device for a cutting element (16) and comprising a specimen holding device (12) for a specimen which is to be cut thin is described. Associated with the specimen holding device (12) for performing a cutting movement is a first drive device (18) and associated with the specimen holding device (12) or the knife holding device is a second drive device (38) for performing a feed movement. A sender (20) is associated with the first drive device (18). The sender (20) is connected with an electronic control means (28). Control of the first drive device (18) is effected by means of a first operating element (28). Control of the second drive device (38) is effected by means of a second operating element (44). To achieve an excellent degree of operating comfort for the microtome the first operating element (28) has two control modes, namely a standard mode and a second mode.