Patents by Inventor Hans Moellering

Hans Moellering has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the production and use of a stable 6-phosphogluconolactonase
    Patent number: 5426034
    Abstract: The invention concerns a new 6-phosphogluconolactonase which has an enzyme activity of at least 90% with respect to the initial activity after about 20 hours at pH 7.0 and 20.degree. C. In addition a process is described for the production of the enzyme from Leuconostoc. The enzyme is preferably suitable for the determination of ATP or reaction partners which can be converted into 6-phosphogluconolactone.
    Type: Grant
    Filed: February 25, 1993
    Date of Patent: June 20, 1995
    Assignee: Boehringer Mannheim GmbH
    Inventors: Hans Moellering, Georg-Burkhard Kresse
  • Pyruvate oxidase mutants, DNA expressing pyruvate oxidase and methods of use thereof
    Patent number: 5153138
    Abstract: The present invention provides a pyruvate oxidase which decarboxylates pyruvate to form inter alia hydrogen peroxide and is active without the addition of FAD, thiamine pyrophosphate and divalent metal ions. The amino acid sequence of the enzyme changes at least one proline in position 178 and alanine in position 458 to a different amino acid. The present invention also provides a process for the preparation of this pyruvate oxidase and methods of use thereof.
    Type: Grant
    Filed: July 26, 1991
    Date of Patent: October 6, 1992
    Assignee: Boehringer Mannheim GmbH
    Inventors: Gunther Schumacher, Hans Moellering
  • Pyruvate oxidase mutants, DNA expressing pyruvate oxidase and methods of use thereof
    Patent number: 5096821
    Abstract: The present invention provides a pyruvate oxidase which decarboxylates pyruvate to form inter alia hydrogen peroxide and is active without the addition of FAD, thiamine pyrophosphate and divalent metal ions. The amino acid sequence of the enzyme changes at least one proline in position 178 and alanine in position 458 to a different amino acid. The present invention also provides a process for the preparation of this pyruvate oxidase and methods of use thereof.
    Type: Grant
    Filed: March 14, 1991
    Date of Patent: March 17, 1992
    Assignee: Boehringer Mannheim GmbH
    Inventors: Gunther Schumacher, Hans Moellering