Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W1, W2, Y, Z, M, L, CY, Cz, R1, R2, R3, R4, R2a, Ry, Rz, and the subscripts m, n, q, and r are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.

Abstract: A profile element for mounting on a vehicle radiator grill. The profile element has a longitudinal extension with a latch provided on an inner side of the profile element. The latch is arranged on the region an edge of the longitudinal extension and adapted to latch to a complementary latch on the vehicle radiator grill. The latch includes a first portion which extends in a substantially cantilevered fashion away from the inner side and a second portion which extends substantially in a direction of the corresponding opposite edge of the longitudinal extension.