Patents by Inventor Hans Schels
Hans Schels has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7863015Abstract: Device, method and kit for carrying out biochemical reactions, in particular for cell-free polypeptide biosynthesis composed of an external housing which encloses an inner housing with incorporated wells and a supply chamber, wherein the wells of the inner housing each contain a producing system during the biochemical reaction, the supply chamber contains a supply liquid during the biochemical reaction and the wells of the inner housing and the supply chamber are separated by a semipermeable membrane characterized in that the inner housing has at least two wells the lower ends of which are closed by a semipermeable membrane and the upper ends of which protrude from the supply liquid contained in the supply chamber, and is connected to means for moving and incubating the producing systems and to the supply liquid.Type: GrantFiled: September 12, 2005Date of Patent: January 4, 2011Assignee: Roche Diagnostics GmbHInventors: Thomas Metzler, Hans Schels, Rolf Reichhuber, Jochen Kluge
-
Patent number: 7156996Abstract: The invention is a multichamber microdialysis device with a multitude of sample chambers in close side by side arrangement (similar to a microtiter plate) for receiving liquid samples, and at least one dialysate chamber for receiving a dialysate liquid. The sample chambers are surrounded by circumferential sidewalls and are in liquid exchange contact to a neighboring dialysis chamber via an exchange opening covered by a semipermeable membrane. The semipermeable membrane is fixed liquid-tight to the walls of the sample chamber, so that a diffusion exchange between the sample chamber and the correspondingly neighboring dialysate chamber is only possible via the membrane. Consequently, only molecules with a molecular weight below the molecular cut-off of the semipermeable membrane can diffuse from the sample chamber to the dialysate chamber or from the dialysate chamber to the sample chamber.Type: GrantFiled: September 2, 2003Date of Patent: January 2, 2007Assignee: Roche Diagnostics Operations, Inc.Inventors: Manfred Watzele, Bernd Buchberger, Hans Schels, Horst Menzler, Ulrike Fischer
-
Publication number: 20060008899Abstract: Device, method and kit for carrying out biochemical reactions, in particular for cell-free polypeptide biosynthesis composed of an external housing which encloses an inner housing with incorporated wells and a supply chamber, wherein the wells of the inner housing each contain a producing system during the biochemical reaction, the supply chamber contains a supply liquid during the biochemical reaction and the wells of the inner housing and the supply chamber are separated by a semipermeable membrane characterized in that the inner housing has at least two wells the lower ends of which are closed by a semipermeable membrane and the upper ends of which protrude from the supply liquid contained in the supply chamber, and is connected to means for moving and incubating the producing systems and to the supply liquid.Type: ApplicationFiled: September 13, 2005Publication date: January 12, 2006Inventors: Thomas Metzler, Hans Schels, Rolf Reichhuber, Jochen Kluge
-
Publication number: 20040195163Abstract: The invention is a multichamber microdialysis device with a multitude of sample chambers in close side by side arrangement (similar to a microtiter plate) for receiving liquid samples, and at least one dialysate chamber for receiving a dialysate liquid. The sample chambers are surrounded by circumferential sidewalls and are in liquid exchange contact to a neighboring dialysis chamber via an exchange opening covered by a semipermeable membrane. The semipermeable membrane is fixed liquid-tight to the walls of the sample chamber, so that a diffusion exchange between the sample chamber and the correspondingly neighboring dialysate chamber is only possible via the membrane. Consequently, only molecules with a molecular weight below the molecular cut-off of the semipermeable membrane can diffuse from the sample chamber to the dialysate chamber or from the dialysate chamber to the sample chamber.Type: ApplicationFiled: September 2, 2003Publication date: October 7, 2004Inventors: Manfred Watzele, Bernd Buchberger, Hans Schels, Horst Menzler, Ulrike Fischer
-
Publication number: 20040115760Abstract: Device, method and kit for carrying out biochemical reactions, in particular for cell-free polypeptide biosynthesis composed of an external housing which encloses an inner housing with incorporated wells and a supply chamber, wherein the wells of the inner housing each contain a producing system during the biochemical reaction, the supply chamber contains a supply liquid during the biochemical reaction and the wells of the inner housing and the supply chamber are separated by a semipermeable membrane characterized in that the inner housing has at least two wells the lower ends of which are closed by a semipermeable membrane and the upper ends of which protrude from the supply liquid contained in the supply chamber, and is connected to means for moving and incubating the producing systems and to the supply liquid.Type: ApplicationFiled: November 25, 2003Publication date: June 17, 2004Inventors: Thomas Metzler, Hans Schels, Rolf Reichhuber, Jochen Kluge
-
Patent number: 6670173Abstract: A bioreaction module for biochemical reactions, in particular for cell-free polypeptide biosynthesis, having a housing (1) including a system chamber (12) and a supply chamber (10), wherein the system chamber (12) contains a producing system during the biochemical reaction and the supply chamber (10) contains a supply liquid during the biochemical reaction, and the system chamber (12) and the supply chamber (10) are separated by a semi-permeable membrane (7). The housing (1) comprises a system chamber element (5) and at least one supply chamber element (3) between which the semi-permeable membrane (7) is mounted in such a manner that the system chamber (12) is defined by the system chamber element (5) and the semi-permeable membrane (7) and the supply chamber (10) is defined by the supply chamber element (3) and the semi-permeable membrane (7).Type: GrantFiled: July 26, 2001Date of Patent: December 30, 2003Assignee: Roche Diagnostics GmbHInventors: Hans Schels, Horst Menzler, Ulrike Fischer
-
Patent number: 6107055Abstract: Method and apparatus for carrying out biochemical reactions in particular for cell-free polypeptide biosynthesis. A bioreactor has, within a housing, a reaction chamber containing a producing system as well as a supply chamber separated from the reaction chamber by means of a semi-permeable membrane and containing a liquid serving as supply medium for the producing system. The supply chamber is subdivided within the bioreactor into a first partial chamber and a second partial chamber which are each connected to the reaction chamber via a semi-permeable supply membrane and which are connected to each other by means of a connection conduit.Type: GrantFiled: July 30, 1998Date of Patent: August 22, 2000Assignee: Roche Diagnostics GmbHInventors: Hermann Bauer, Horst Menzler, Gerd Kleinhammer, Hans Schels, Peter Bendzko, Ute Fink, Bernd Maciej
-
Patent number: 5819508Abstract: Device for pulling out or twisting off caps from vessels, wherein the vessel is held, and the cap is removed by means of a cap-holding device; the cap-holding device executes both a linear movement in direction of the vessel axis as well as a rotating movement around the vessel axis. The cap-holding device advantageously has several clamping jaws that are pressed against the circumference of the cap.Type: GrantFiled: April 4, 1996Date of Patent: October 13, 1998Assignee: Boehringer Mannheim GmbHInventors: Peter Kraft, Horst Menzler, Hans Schels, Peter Wenzig
-
Patent number: 5780306Abstract: The invention relates to a system for mixing a liquid with another liquid or a solid material by blowing a gas onto the surface of the liquid. The invention further relates to a system for implementing said method. Gas is blown onto the surface of the liquid from a distance which can be adjusted by determining the level of the liquid. A system of the invention, hence, comprises a device for blowing a gas onto the surface of a liquid and a device for detecting the level of a liquid.Type: GrantFiled: November 7, 1996Date of Patent: July 14, 1998Assignee: Boehringer Mannheim GmbHInventors: Hans Schels, Karl-Heinz Mann, Horst Menzler, Leonhard Geissler, Georg Kuffer
-
Patent number: 5362147Abstract: Method for the contactless automatic mixing of a liquid reaction mixture in an analysis unit, in which the reaction mixture is located in a vessel accessible from above through an opening, by means of a gas jet escaping from an outlet opening of a mixing element, a rapid, effective and reliable non-invasive thorough mixing of the liquid is achieved by the mixing element being lowered at the start of the mixing operation in the direction of the liquid surface and the lowering movement being stopped in a bottom end position in which the mixing element projects into the vessel, but does not touch the liquid surface, the gas jet is switched on during the lowering of the mixing element, the gas jet is so aligned that it brings about an asymmetrical lowering of a part of the liquid surface in the vicinity of the vessel wall, and the gas jet has a rotational component of motion so that the lowered part of the liquid surface is set in rotation about the axis of the vessel.Type: GrantFiled: September 21, 1993Date of Patent: November 8, 1994Assignee: Boehringer Mannheim GmbHInventors: Hans Schels, Horst Menzler
-
Patent number: D437408Type: GrantFiled: October 25, 1999Date of Patent: February 6, 2001Assignee: Roche Diagnostics GmbHInventors: Horst Menzler, Hans Schels