Abstract: The invention provides a modified T cell, or an isolated population of immune cells expressing a CXCR3 isoform selected from CXCR3A, CXCR3B, and CXCR3alt, and optionally, further expressing transgenes comprising an artificial T cell receptor, and/or a CXCR3 ligand, for use as a medicament. The invention also provides the methods to obtain said cells, or populations of cells from a plurality of immune cells derived from a human subject. The invention also relates to assessment of CXCR3 splice variants and its ligands CXCL9, CXCL10, and CXCL11 in muscle-invasive bladder cancer (MIBC) patients, to enable patients to be stratified for their predicted response to a chemotherapy drug treatment, or clinical outcome.

Abstract: A method of manufacturing a wound insulator pipe, in particular for a high voltage insulator, having one or more ducts for conductors of any kind is provided. A laminate structure is achieved by winding a material onto a spindle and impregnating with a resin. Initially first layers of the material to be wound are applied; then at least one groove is made in the surface obtained and then the winding is completed until the final diameter is attained.

Abstract: A method for producing a wound insulating conduit, in particular for a high-voltage insulator, with at least one empty channel for subsequent insertion of a conductor, e.g., an optical fiber. First layers of a material to be wound are applied first, then a molded body provided with at least one empty conduit is applied to a resulting surface and wrapped by additional layers. The molded body has lateral projections which extend over an entire length of the empty conduit and are designed so that they correspond to the surface to which it is secured.