Patents by Inventor Hans Ulrich Stilz

Hans Ulrich Stilz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclic indole-3-carboxamides, their preparation and their use as pharmaceuticals
    Patent number: 8211885
    Abstract: The present invention relates to cyclic indole-3-carboxamides of the formula I, wherein A, R, R10, R20, R30, R40, n, p and q have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they inhibit the enzyme renin and modulate the activity of the renin-angiotensin system, and are useful for the treatment of diseases such as hypertension, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: July 3, 2012
    Assignee: Sanofi-Aventis
    Inventors: Henning Steinhagen, Bodo Scheiper, Hans Matter, Hans Ulrich Stilz, Gary McCort
  • CYCLIC INDOLE-3-CARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
    Publication number: 20110039830
    Abstract: The present invention relates to cyclic indole-3-carboxamides of the formula I, wherein A, R, R10, R20, R30, R40, n, p and q have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they inhibit the enzyme renin and modulate the activity of the renin-angiotensin system, and are useful for the treatment of diseases such as hypertension, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
    Type: Application
    Filed: July 28, 2010
    Publication date: February 17, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Henning STEINHAGEN, Bodo SCHEIPER, Hans MATTER, Hans Ulrich STILZ, Gary MCCORT
  • Cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists
    Patent number: 7348333
    Abstract: There are described cycloalkyl derivatives of the formula (I) R1—Y-A-B-D-E-F-G??(I) in which R1, Y, A, B, D, E, F and G have the meaning indicated herein, their preparation and their use as medicaments. The compounds according to the invention can be used as vitronectin receptor antagonists and as inhibitors of bone resorption.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: March 25, 2008
    Assignee: Aventis Pharma S.A.
    Inventors: Volkmar Wehner, Jochen Knolle, Hans Ulrich Stilz, Jean-Francois Gourvest, Denis Carniato, Thomas Richard Gadek, Robert McDowell, Robert Maurice Pitti, Sarah Catherine Bodary
  • Substituted indoles
    Patent number: 7342029
    Abstract: Compounds of the formula I are suitable for preparing pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NF?B is involved.
    Type: Grant
    Filed: July 22, 2005
    Date of Patent: March 11, 2008
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Olaf Ritzeler, Hans Ulrich Stilz, Bernhard Neises, Gerhard Jaehne, Joerg Habermann
  • Imidazolidine derivatives, their preparation and their use
    Patent number: 6962937
    Abstract: The present invention relates to novel imidazolidine derivatives of the formula I, in which B, E, W, Y, R, R2, R3, R30, e and h have the meanings given herein. The compounds of the formula I are valuable pharmaceutically active compounds which are suitable, for example, for treating inflammatory diseases, for example, rheumatoid arthritis, or allergic diseases. The compounds of the formula I are inhibitors of the adhesion and migration of leukocytes and/or antagonists of the adhesion receptor VLA-4, which belongs to the integrin group. They are generally suitable for treating diseases which are caused by, or associated with, an undesirable degree of leukocyte adhesion and/or leukocyte migration or in which cell-cell or cell-matrix interactions, which are based on the interactions of VLA-4 receptors with their ligands, play a role.
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: November 8, 2005
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Volkmar Wehner, Stefanie Flohr, Horst Blum, Hartmut Rütten, Hans Ulrich Stilz
  • Vitronectin receptor antagonists, their preparation and their use
    Patent number: 6867208
    Abstract: The present invention relates to compounds of the formula I A—B—D—E—F—G??(I) in which A, B, D, E, F and G have the meanings given in the patent claims, to their preparation and to their use as medicaments. The compounds of the invention are used as vitronectin receptor antagonists and as inhibitors of bone resorption.
    Type: Grant
    Filed: May 13, 2002
    Date of Patent: March 15, 2005
    Assignees: Hoechst Aktiengesellschaft, Genentech, Inc.
    Inventors: Volkmar Wehner, Hans Ulrich Stilz, Anuschirwan Peyman, Jochen Knolle, Jean-Marie Ruxer, Denis Carniato, Jean-Michel Lefrancois, Thomas Richard Gadek, Robert McDowell
  • Heterocytes as inhibitors of leucocyte adhesion and as VLA-4 antagonists
    Patent number: 6838439
    Abstract: The present invention relates to compounds of the formula I which are inhibitors of the adhesion and migration of leucocytes and/or antagonists of the adhesion receptor VLA-4 which belongs to the group of integrins. The invention also relates to processes for the preparation of formula I, pharmaceutical compositions containing compounds of formula I, and the treatment or prophylaxis of various diseases caused by or are associated with excess leucocyte adhesion and/or leucocyte migration, as well as diseases associated with cell-cell or cell-matrix interactions, which on interactions of VLA-4 receptors with their ligands play a part of, for example, inflammatory processes, rheumatoid arthritis or allergic disorders.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: January 4, 2005
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Hans Ulrich Stilz, Volkmar Wehner, Christoph Huls, Dirk Seiffge
  • 5-Membered ring heterocycles as inhibitors of leucocyte adhesion and as VLA-4 antagonists
    Publication number: 20040220148
    Abstract: Compounds of the formula I 1
    Type: Application
    Filed: October 24, 2003
    Publication date: November 4, 2004
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Hans Ulrich Stilz, Volkman Wehner, Jochen Knolle, Eckart Bartnik, Christoph Huels
  • Substituted indoles
    Publication number: 20040209868
    Abstract: Compounds of the formula I 1
    Type: Application
    Filed: May 11, 2004
    Publication date: October 21, 2004
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Olaf Ritzeler, Hans Ulrich Stilz, Bernhard Neises, Gerhard Jaehne, Jorg Habermann
  • Bis(trifluoromethyl)hydantoins as intermediates for pharmaceutically active ingredients
    Patent number: 6794517
    Abstract: The present invention relates to hydantoins of formula I, in which R is the residue of an amino carboxylic acid or of an amino carboxylic acid derivative, which is obtained formally by removing an NH2 group from an amino carboxylic acid or an amino carboxylic acid derivative, to the preparation thereof and to the use thereof as intermediates, in particular for preparing pharmaceutically active ingredients.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: September 21, 2004
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Volkmar Wehner, Hans Ulrich Stilz, Klaus Burger, Alexander Golubev, Sergej Ossipov
  • Imidazolidine derivatives, their preparation, their use, and pharmaceutical preparations comprising them
    Patent number: 6759424
    Abstract: The present invention relates to novel imidazolidine derivatives of the formula I, in which B, E, W, Z, R, R0, R2, R3, e and h have the meanings indicated in the application. The compounds of the formula I are valuable pharmaceutical active compounds, which are suitable, for example, for the therapy and prophylaxis of inflammatory disorders, for example of rheumatoid arthritis, or of allergic disorders. The compounds of the formula I are inhibitors of the adhesion and migration of leucocytes and/or antagonists of the adhesion receptor VLA-4 belonging to the integrins group. They are generally suitable for the therapy or prophylaxis of illnesses which are caused by an undesired extent of leucocyte adhesion and/or leucocyte migration or are associated therewith, or in which cell-cell or cell-matrix interactions which are based on interactions of VLA-4 receptors with their ligands play a part.
    Type: Grant
    Filed: May 20, 2002
    Date of Patent: July 6, 2004
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Volkmar Wehner, Hans Ulrich Stilz, Wolfgang Schmidt, Dirk Seiffge
  • Imidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them
    Patent number: 6680333
    Abstract: The present invention relates to novel imidazolidine derivatives of formula I, wherein A, E, Z, R1, R2, R3, R4 and R5 have the meanings indicated in the claims. The compounds of formula I are valuable pharmaceutical active compounds which are suitable, for example, for the treatment of inflammatory diseases, including rheumatoid arthritis, or allergic diseases. The compounds of formula I are inhibitors of the adhesion and migration of leukocytes and/or antagonists of the adhesion receptor VLA-4 belonging to the integrins group. They are generally suitable for the treatment of diseases which are caused by an undesired extent of leukocyte adhesion and/or leukocyte migration or are associated therewith or in which cell-cell or cell-matrix interactions which are based on the interactions of VLA-4 receptors with their ligands play a role.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: January 20, 2004
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Volkmar Wehner, Horst Blum, Hartmut Rütten, Hans Ulrich Stilz
  • Imidazolidine derivatives, the production thereof, their use and pharmaceutical preparations containing the same
    Patent number: 6667334
    Abstract: The present invention relates to imidazolidine derivatives of the formula I, in which B, E, W, Y, R, R2, R3, R30, e and h have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds, which are suitable, for example, for the therapy and prophylaxis of inflammatory disorders, for example of rheumatoid arthritis, or of allergic disorders. The compounds of the formula I are inhibitors of the adhesion and migration of leukocytes and/or antagonists of the adhesion receptor VLA-4 belonging to the integrins group. They are generally suitable for the therapy or prophylaxis of diseases which are caused by an undesired extent of leukocyte adhesion and/or leukocyte migration or are associated therewith, or in which cell-cell or cell-matrix interactions which are based on interactions of VLA-4 receptors with their ligands play a part.
    Type: Grant
    Filed: March 12, 2001
    Date of Patent: December 23, 2003
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Bernhard Neises, Volkmar Wehner, Hans Ulrich Stilz
  • Inhibitors of bone reabsorption and antagonists of vitronectin receptors
    Patent number: 6620820
    Abstract: The present invention relates to 5-membered ring heterocycles of the formula I, in which E, F, G, W, Y and Z have the meaning given in the patent claims, to their preparation and to their use as medicaments. The novel compounds are used as vitronectin receptor antagonists and as inhibitors of bone reabsorption.
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: September 16, 2003
    Assignees: Hoechst Aktiengesellschaft, Genentech, Inc.
    Inventors: Volkmar Wehner, Jochen Knolle, Hans Ulrich Stilz, Denis Carniato, Jean-Francois Gourvest, Tom Gadek, Robert McDowell
  • Imidazolidine derivatives, their preparation, their use, and pharmaceutical preparations comprising them
    Publication number: 20030125565
    Abstract: The present invention relates to novel imidazolidine derivatives of the formula I, 1
    Type: Application
    Filed: May 20, 2002
    Publication date: July 3, 2003
    Inventors: Volkmar Wehner, Hans Ulrich Stilz, Wolfgang Schmidt, Dirk Seiffge
  • Vitronectin receptor antagonists, their preparation and use
    Publication number: 20030119785
    Abstract: The present invention relates to compounds of the formula I,
    Type: Application
    Filed: November 19, 2002
    Publication date: June 26, 2003
    Applicant: Hoechst Aktiengesellschaft and Genentech Inc.
    Inventors: Volkmar Wehner, Hans Ulrich Stilz, Anuschirwan Peyman, Karlheinz Scheunemann, Jean-Marie Ruxer, Denis Carniato, Jean-Michel Lefrancois, Thomas Richard Gadek, Robert McDowell
  • Substituted indoles
    Publication number: 20030119820
    Abstract: Compounds of the formula I 1
    Type: Application
    Filed: October 4, 2002
    Publication date: June 26, 2003
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Olaf Ritzeler, Hans Ulrich Stilz, Bernhard Neises, Gerhard Jaehne, Jorg Habermann
  • Novel imidazolidine derivatives, their preparation and their use
    Publication number: 20030109497
    Abstract: The present invention relates to novel imidazolidine derivatives of the formula I, 1
    Type: Application
    Filed: July 31, 2002
    Publication date: June 12, 2003
    Inventors: Volkmar Wehner, Stefanie Flohr, Horst Blum, Hartmut Rutten, Hans Ulrich Stilz
  • Novel imidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them
    Publication number: 20030073723
    Abstract: The present invention relates to novel imidazolidine derivatives of formula I, 1
    Type: Application
    Filed: March 8, 2002
    Publication date: April 17, 2003
    Inventors: Volkmar Wehner, Horst Blum, Hartmut Rutten, Hans Ulrich Stilz
  • Novel cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists
    Publication number: 20030050314
    Abstract: There are described cycloalkyl derivatives of the formula (I)
    Type: Application
    Filed: May 10, 2002
    Publication date: March 13, 2003
    Applicant: Aventis Pharma S.A.
    Inventors: Volkmar Wehner, Jochen Knolle, Hans Ulrich Stilz, Jean-Francois Gourvest, Denis Carniato, Thomas Richard Gadek, Robert McDowell, Robert Maurice Pitti, Sarah Catherine Bodary