Abstract: An improved, injection or blood removal device for intravenous access has a port with a septum at the exterior end of an intravenous catheter, a coupling element having an adhesive surface for securing attachment onto the skin, an injection or blood sampling unit, a connecting cannula piercing the septum of the port, and means to secure functional assembly. Attachment of the device to the skin covering or close to the intravenous puncture site and without long communicating tubes allows ambulant injection of drugs or measuring of concentration-time profiles of exogenous and endogenous analytes to improve treatment modalities on an individualized basis.

Abstract: In a device for ambulatory wearing by the patient containing a pump for delivery of injection fluid or for removal of analysis fluid, the drive motor for the mechanically driven pump system is a Lavet-type stepper motor of small size designed for having a high mechanical power and low peak current requirement. Using this Lavet-type motor for syringe-type or peristaltic preferably patch-type pumps high infusion rates needed for e.g. bolus insulin injection or the delivery of therapeutic antibodies are achieved, and important safety features can be easily and reliably controlled, manufacturing costs get significantly reduced, and the overall size and weight of the device becomes smaller, for patient convenience.

Abstract: An improved diagnostic analyte monitoring device has partially retractable hollow guide needles for the intradermal placement of diagnostic elements fixedly connected to measuring means within this device obviating the need to remove the guide needle and to connect the diagnostic elements to measuring means after placement into the skin. A flexible surface adhering to the skin serves for the subcutaneous implantation of the diagnostic elements within the guide needles and partial retraction of the guide needles exposes the active surface to body fluid, actuated by means designed for easy handling and safe operation. Concentration-time profiles of endogenous and exogenous analytes measured with the device are used to improve drug treatment modalities on an individualized basis.

Abstract: A sub-epidermal electric warning device has electrodes penetrating through the patient's epidermis and bipolar electric warning signals are transmitted to the sub-epidermal tissue by these electrodes. A device for surveillance of vital signs, analyte levels, or treatment parameters is using a sub-epidermal electric warning device for notifying the patient in situations requiring intervention.

Abstract: A sub-epidermal electric warning device has electrodes penetrating through the patient's epidermis and bipolar electric warning signals are transmitted to the sub-epidermal tissue by these electrodes. A device for surveillance of vital signs, analyte levels, or treatment parameters is using a sub-epidermal electric warning device for notifying the patient in situations requiring intervention.

Abstract: In a syringe type pump with a barrel (2) and a piston (4) movable in the interior of the barrel the barrel has the shape of a segment of a toroidal tube (2) and the piston is moved by means of a driving rod (6) which is guided and supported by the inner surface of the barrel wall. By the toroidal shape the overall size of the pump is significantly reduced and by guiding and supporting the driving rod of the piston by the inner surface of the barrel wall intrinsic problems of tightness, stick-slip phenomena and blockage are solved. A device for injecting fluid into a patient's body or removing body fluid therefrom is using a syringe type pump with a toroidal barrel and a driving rod of the piston guided and supported by the inner surface of the barrel wall.

Abstract: The subcutaneous injection device contains a pump and a mechanism for inserting a cannula into the patient's skin. The cannula is fixedly positioned relative to the pump and the insertion mechanism has a flexible surface adhering to the skin. The flexible surface is positioned relative to the cannula in such a way that in a first position the tip of the cannula is concealed by the surface and in a second position the cannula is exposed beyond the surface. The insertion mechanism brings the surface from the first to the second position, thereby pulling the skin against the tip of the cannula.

Abstract: A skin insertion mechanism includes a needle fixedly positioned in a needle holder with a connector (or connective means) to an injection or analysis system having a skin attachment plate coated with an adhesive layer and a spacer mechanism kept in the ready-to-use position, the skin attachment plate is spaced away from a needle support covering the needle. Subcutaneous insertion of the needle is effected by attachment of the adhesive layer to the skin and releasing the spacer mechanism by applying a pre-set trigger point pressure against the skin.

Abstract: A subcutaneous access device has a skin attachment plate coated with an adhesive layer. The skin attachment plate is moveably linked by a retraction mechanism to a needle support with fixedly positioned needles. In the ready-to-use position the skin attachment plate is spaced away from the needle support and covers the fixedly positioned needles. Subcutaneous insertion of the needles is effected by attachment of the skin attachment plate with the adhesive layer to the skin and releasing the retraction mechanism, thus triggering the pulling of the attached skin with high velocity against the tip of the needles.

Abstract: In a device for ambulatory wearing by the patient containing a pump for delivery of injection fluid or for removal of analysis fluid, the drive motor for the mechanically driven pump system is a Lavet-type stepper motor of small size designed for having a high mechanical power and low peak current requirement. Using this Lavet-type motor for syringe-type or peristaltic preferably patch-type pumps high infusion rates needed for e.g. bolus insulin injection or the delivery of therapeutic antibodies are achieved, and important safety features can be easily and reliably controlled, manufacturing costs get significantly reduced, and the overall size and weight of the device becomes smaller, for patient convenience.

Abstract: The subcutaneous injection device contains a pump and a mechanism for inserting a cannula into the patient's skin. The cannula is fixedly positioned relative to the pump and the insertion mechanism has a flexible surface adhering to the skin. The flexible surface is positioned relative to the cannula in such a way that in a first position the tip of the cannula is concealed by the surface and in a second position the cannula is exposed beyond the surface. The insertion mechanism brings the surface from the first to the second position, thereby pulling the skin against the tip of the cannula.

Abstract: A sub-epidermal electric warning device has electrodes penetrating through the patient's epidermis and bipolar electric warning signals are transmitted to the sub-epidermal tissue by these electrodes. A device for surveillance of vital signs, analyte levels, or treatment parameters is using a sub-epidermal electric warning device for notifying the patient in situations requiring intervention.

Abstract: A subcutaneous access device has a skin attachment plate coated with an adhesive layer. The skin attachment plate is moveably linked by a retraction mechanism to a needle support with fixedly positioned needles. In the ready-to-use position the skin attachment plate is spaced away from the needle support and covers the fixedly positioned needles. Subcutaneous insertion of the needles is effected by attachment of the skin attachment plate with the adhesive layer to the skin and releasing the retraction mechanism, thus triggering the pulling of the attached skin with high velocity against the tip of the needles.

Abstract: A skin insertion mechanism of a needle fixedly positioned in a needle holder with connective means to an injection or analysis system has a skin attachment plate coated with an adhesive layer and a spacer mechanism keeping in the ready-to-use position the skin attachment plate spaced away from the needle support covering the needle. Subcutaneous insertion of the needle is effected by attachment with the adhesive layer to the skin and releasing the spacer mechanism by applying a pre-set trigger point pressure against the skin.

Abstract: An improved, injection or blood removal device for intravenous access has a port with a septum at the exterior end of an intravenous catheter, a coupling element having an adhesive surface for securing attachment onto the skin, an injection or blood sampling unit, a connecting cannula piercing the septum of the port, and means to secure functional assembly. Attachment of the device to the skin covering or close to the intravenous puncture site and without long communicating tubes allows ambulant injection of drugs or measuring of concentration-time profiles of exogenous and endogenous analytes to improve treatment modalities on an individualized basis.

Abstract: In a syringe type pump with a barrel (2) and a piston (4) movable in the interior of the barrel the barrel has the shape of a segment of a toroidal tube (2) and the piston is moved by means of a driving rod (6) which is guided and supported by the inner surface of the barrel wall. By the toroidal shape the overall size of the pump is significantly reduced and by guiding and supporting the driving rod of the piston by the inner surface of the barrel wall intrinsic problems of tightness, stick-slip phenomena and blockage are solved. A device for injecting fluid into a patient's body or removing body fluid therefrom is using a syringe type pump with a toroidal barrel and a driving rod of the piston guided and supported by the inner surface of the barrel wall.

Abstract: An improved diagnostic analyte monitoring device has partially retractable hollow guide needles for the intradermal placement of diagnostic elements fixedly connected to measuring means within this device obviating the need to remove the guide needle and to connect the diagnostic elements to measuring means after placement into the skin. A flexible surface adhering to the skin serves for the subcutaneous implantation of the diagnostic elements within the guide needles and partial retraction of the guide needles exposes the active surface to body fluid, actuated by means designed for easy handling and safe operation. Concentration-time profiles of endogenous and exogenous analytes measured with the device are used to improve drug treatment modalities on an individualized basis.

Abstract: A nuclear magnetic resonance (NMR) spectrometer for investigating a liquid sample in a sample tube, in particular a glass sample tube (12), has a sample bushing (1) surrounding the sample tube having a bore into which one end of the sample tube is inserted with tight fit. The sample bushing (1) is preferably substantially cylindrical and the bore extends along the cylindrical axis. The NMR spectrometer has a gripping device (13) for handling the sample bushing (1), the gripping device (13) having at least three gripping fingers (14a-14d), and the outer periphery of the sample bushing (1) has at least one groove (2) into which the gripping fingers (14a-14d) can engage to press onto the two outer edges of the groove (2) when the gripping device (13) is closed. The cooperation between the groove and the gripping device permits fully automated, precise handling of the samples.

Abstract: An integrally built, linear array of cuvettes is made of a plastic material. This array comprises a plurality of cuvettes arranged along a straight line in an array, each cuvette in the array having the same shape and dimensions, and neighboring cuvettes being connected to each other by a single web. Each of the single webs has a curved shape. The symmetry axis (Y-Y) of every cuvette forming part of said array of cuvettes lies substantially in one and the same plane (A-A) which is a symmetry plane of said cuvette array. The upper part of at least one intermediate cuvette which is located between a first cuvette located at one end of the cuvette array and a second cuvette located at the opposite end of the cuvette array is connected by a first single web to the upper part of a neighboring cuvette lying on one side of said intermediate cuvette and is connected by a second single web to the upper part of a neighboring cuvette lying on the opposite side of said intermediate cuvette.

Abstract: An integrally built, linear array of cuvettes is made of a plastic material. Every cuvette of the array has the same shape and dimensions. Neighboring cuvettes are connected to each other by a single web. Each of the single webs has a curved shape and each cuvette has means forming integral part thereof and serving for accurately positioning the cuvette into an opening of a cuvette holder and means for removably connecting the cuvette to the cuvette holder. Each cuvette has an upper chamber and a lower chamber having a common symmetry axis passing through the centers of both chambers. Each of the upper and lower chambers has a substantially cylindrical shape. The cross-section of the upper chamber at the central part thereof is larger than the cross-section of the lower chamber. The lower chamber has an open lower end. The upper chamber has an open top end and an annular bottom wall having a central circular opening which connects the upper chamber with the lower chamber.