Abstract: A display device for ultrasound energy includes a focused ultrasound emitting and receiving device, a processing device and a display. The processing device generates a first electrical signal and transmits it to the focused ultrasound emitting and receiving device to control the focused ultrasound emitting and receiving device to emit at least one first ultrasound signal to a target position of an organism. The target position reflects the first ultrasound signal to form at least one second ultrasound signal. After generating the first electrical signal, the processing device drives the focused ultrasound emitting and receiving device to start to receive the second ultrasound signal only during a preset period after the estimation period. The processing device uses the display to display an image of the target position according to the second ultrasound signal, and brightness of the image is directly proportional to energy intensity of the first ultrasound signal.

Abstract: A processing system and a confocal processing method for confocally emitting and receiving ultrasound. Firstly, a first driving electrical signal is generated. Then, at least one first ultrasound signal having a main frequency is emitted to a reflection position according to the first driving electrical signal. With an object at the reflection position, the first ultrasound signal is reflected to form at least one second ultrasound signal. Then, a first analyzed signal whose frequency lower than the main frequency is retrieved from the second ultrasound signal, and other signals are eliminated from the second ultrasound signal, and the first analyzed signal is converted into at least one first analogous signal. Finally, first energy of a first fixed bandwidth of the first analyzed signal is retrieved by the first analogous signal. The method stops generating the first driving electrical signal when the first energy is larger than a predetermined value.

Abstract: A method for dynamically analyzing distribution variation of scatterers is provided and used for dynamically analyzing changes in two or three dimensional scatterer distribution and concentration of ultrasound data by using probability density function along with a moving window technique. The present invention has advantages in low computation load and may be used for real-time analysis. A method for dynamically detecting thermal ablation area and thermal ablation level and a method for dynamically controlling thermal ablation intensity are also provided for non-invasive detection and thermal ablation.

Abstract: The present invention proposes a magnetic nanocomposite with multi-biofunctional groups, which comprises a core and a shell wrapping the core, wherein the core contains magnetic nanoparticles, and wherein the shell is made of a conductive polymer with multi-biofunctional groups where a medicine, an antibody or a fluorescent label can be attached.

Abstract: The present invention discloses a magnetic nanomedicine for inhibiting/treating human prostate cancer, which comprises a core containing a magnetic particle having a diameter of less than 10 nm; a shell made of a carboxylated polyaniline and encapsulating the core; and a medicine covalently linked to the shell and able to inhibit/treat prostate cancer. The magnetic nanomedicine of the present invention not only has superior thermal stability and but also has water solubility higher than that of the conventional anti-prostate cancer medicine. Further, the magnetic nanomedicine of the present invention can be magnetically conducted to the cancer area to increase the local concentration of medicine and enhance the therapeutic effect.

Abstract: A multi-channel hemispherical ultrasonic wave transmit and receive detection system and method, wherein, a transmit control system transmits out a plurality of detection signals through an energy converter, a receive system receives the reflected signals reflected from an obstacle, in determining a channel used by said transmit control system to control a multiplexer to select a channel to switch to and then amplify said reflected signals. Then, said receive system performs high speed analog-to-digital sampling, and high speed transmission through USB for said reflected signals amplified. Finally, a Graphic User Interface (GUI) of a computer performs smooth-out processing for said reflected signals and displays its waveforms, in determining distance to said obstacle.

Abstract: The present invention discloses a neuronavigation-guided focused ultrasound system and a method for the same, which are used to guide focused ultrasound energy to a target point. The system of the present invention comprises a focused ultrasound device, a neuronavigation system and a fixture. According to an image of an interested region of an individual, a focus point of the focused ultrasound device, and tracking points provided by the neuronavigation system, the neuronavigation system performs a calibration process and establishes a positional relationship between the focus point and the image of the interested region. Thereby, the neuronavigation system can recognize the focus point and guide focused ultrasound to the target point.

Abstract: An apparatus for sonicating a patient includes an ultrasound array having a plurality of transducers; a driving module for driving said transducers; and a control kernel for causing said driving module to drive said transducers concurrently at two different frequencies.

Abstract: The invention discloses the Schlieren type ultrasonic wave observer system. The invention states optics interference by the ultrasonic wave sound field after perturbation the medium, and combines to make the interference penetration optical projection the image, the goal lies in the observation ordinary naked eye blind ultrasonic wave sound field distribution. Characteristic of the invention using the spectroscope and the reflector combination, as well as microcontroller precise time delay control, might formerly be limited under the 4F optical field length limit to enhance largely the field of vision the several fold.

Abstract: The present invention discloses a magnetic nanomedicine for inhibiting/treating human prostate cancer, which comprises a core containing a magnetic particle having a diameter of less than 10 nm; a shell made of a carboxylated polyaniline and encapsulating the core; and a medicine covalently linked to the shell and able to inhibit/treat prostate cancer. The magnetic nanomedicine of the present invention not only has superior thermal stability and but also has water solubility higher than that of the conventional anti-prostate cancer medicine. Further, the magnetic nanomedicine of the present invention can be magnetically conducted to the cancer area to increase the local concentration of medicine and enhance the therapeutic effect.

Abstract: A multi-channel hemispherical ultrasonic wave transmit and receive detection system and method, wherein, a transmit control system transmits out a plurality of detection signals through an energy converter, a receive system receives the reflected signals reflected from an obstacle, in determining a channel used by said transmit control system to control a multiplexer to select a channel to switch to and then amplify said reflected signals. Then, said receive system performs high speed analog-to-digital sampling, and high speed transmission through USB for said reflected signals amplified. Finally, a Graphic User Interface (GUI) of a computer performs smooth-out processing for said reflected signals and displays its waveforms, in determining distance to said obstacle.

Abstract: A medical system and method for treating a disorder of a subject by thermal ablation, e.g., focused ultrasound thermal ablation, are provided. The method includes obtaining medical images that include at least one image of subject's chest and ribs to reconstruct a three-dimensional chest-rib distribution; and applying ultrasound waves on a target point beyond the subject's ribs by selectively activating one or more elements of an ultrasound phased array to avoid ultrasonic energy absorption or reflection by an intervening rib based on a calculation of a relationship between the three-dimensional chest-rib distribution and an acoustic emission direction.

Abstract: The invention is to a biomedical used multiple-channel hemispherical focused ultrasound phased array apparatus. The invention comprises of a graphic user interface, digital multiple channel phase control kernel, multiple channel driving system, and impedance matching module, power feedback device, as well as the hemispherical low-frequency ultrasound phased array. The invention also serves as a good platform reference to develop a focused ultrasound system in the assisted brain drug delivery application.

Abstract: The invention is disclosed to design a real-time pulse/echo system to perform 1-D real-time temperature measurement and integrate in the high-intensity focused ultrasound system. In the invention, a modified echo-time shifting algorithm is developed to calculate the corresponding phase shift from echo signal, which correlates with the instantaneous temperature change during heating process.

Abstract: A drug delivery system of a target drug and method of implementing the same. Said drug delivery system of target drug comprising: a plurality of drug-carrying magnetic particles, a magnetic field generation device, and an ultrasound generation device. Said magnetic field generation device generates a magnetic field to guide said magnetic particles to a target activity position; and said ultrasound generation device generates ultrasound to make said magnetic particles into a suspension state, thus increasing reaction area, enhancing local reaction of drug, such that local retention of drug is able to achieve maximum therapeutic effects at reduced drug dosage.

Abstract: An apparatus for sonicating a patient includes an ultrasound array having a plurality of transducers; a driving module for driving said transducers; and a control kernel for causing said driving module to drive said transducers concurrently at two different frequencies.

Abstract: The invention discloses the Schlieren type ultrasonic wave observer system. The invention states optics interference by the ultrasonic wave sound field after perturbation the medium, and combines to make the interference penetration optical projection the image, the goal lies in the observation ordinary naked eye blind ultrasonic wave sound field distribution. Characteristic of the invention using the spectroscope and the reflector combination, as well as microcontroller precise time delay control, might formerly be limited under the 4F optical field length limit to enhance largely the field of vision the several fold.

Abstract: Disclosed herein is a method for treating a brain disease in which focused ultrasound and magnetic targeting are applied to a subject in need of such treatment, so that therapeutic agent-magnetic nanoparticle composites are directed across the blood-brain barrier to a designated locus inside the brain of the subject. Each of the composites includes a magnetic nanoparticle that is formed of an iron-based core and a shell encapsulating the iron-based core, and a therapeutic agent that is bound to the shell of the magnetic nanoparticle. The magnetic nanoparticle has a size ranging from 5 to 200 nm. The iron-based core has a crystalline structure that imparts the composites with a sufficiently high magnetization, thereby enhancing magnetic targeting of the composites to the designated locus inside the brain of the subject. The magnetic targeting treatment is conducted via a magnet providing a magnetic flux density not less than 0.18 T.

Abstract: A method for dynamically analyzing distribution variation of scatterers is provided and used for dynamically analyzing changes in two or three dimensional scatterer distribution and concentration of ultrasound data by using probability density function along with a moving window technique. The present invention has advantages in low computation load and may be used for real-time analysis. A method for dynamically detecting thermal ablation area and thermal ablation level and a method for dynamically controlling thermal ablation intensity are also provided for non-invasive detection and thermal ablation.

Abstract: The invention disclosed a high-intensity focused ultrasound thermal ablation apparatus having integrated temperature estimation and elastography for thermal lesion determination and the method thereof, using the different power to burn by the same focused ultrasound transducer, and then using the apparatus to measure the temperature and elasticity estimating by the relevant analysis method.