Abstract: Provided are a fused tricyclic cyclin-dependent kinase inhibitor, and a preparation method therefor and a pharmaceutical use thereof. In particular, the structure of the fused tricyclic cyclin-dependent kinase inhibitor is shown in formula I, wherein substituents are defined in the description. The fused tricyclic cyclin-dependent kinase inhibitor is used for preventing and/or treating cyclin-dependent kinase related diseases, in particular cancers.

Abstract: An electronic device may be provided with peripheral conductive housing structures having first and second segments. A flexible printed circuit may have a first tail that extends along the first and second segments and a second tail that extends along the first segment. A conductive trace on the first tail may be coupled to an antenna feed terminal on the second segment. A conductive trace on the second tail may couple the conductive trace on the first tail to the first segment. A tuner and filters may be disposed on the flexible printed circuit and may be coupled to the conductive traces. The conductive trace on the second tail may have a tapered width. An antenna in the device may have a resonating element that includes both the first and second segments, thereby allowing the antenna to exhibit a wide bandwidth from 1.1-5 GHz.

Abstract: Embodiments of the present disclosure relate to a permission setting method and apparatus, a device, and a medium. The method includes: displaying a permission customization control, in response to a trigger operation on a permission setting object of task information, the permission setting object including a first information object and/or a second information object, the second information object being subordinate to the first information object; displaying a permission editing interface, in response to a trigger operation on the permission customization control, and receiving customization permission information via the permission editing interface; and displaying the customization permission information corresponding to the permission setting object. Therefore, a hierarchy structure based on the task information satisfies a setting need for content-based permission customization, and improves a permission management efficiency.

Abstract: An aluminum borate whisker reinforced and toughened non-metallic matrix composite is provided, which specifically includes a non-metallic material reinforced and toughened with aluminum borate whiskers. The composite exhibits a higher bending strength and fracture toughness and a higher wear resistance. A method for preparing the composite is also provided. The method includes mixing the aluminum borate whiskers and the non-metallic material to form a mixture; and sintering the mixture by a vacuum hot press method, or molding the mixture.

Abstract: A backside illuminated (BSI) image sensor substrate and a method of manufacturing a BSI image sensor are disclosed. A first nitride layer (9) is formed on a metal material layer (70), and a first dry etching process is then performed on both the first nitride layer (9) and the metal material layer (70). In this way, during the etching of the metal material layer (70), the first nitride layer (9) is bombarded so that nitrogen atoms or nitrogen ions escape from the first nitride layer (9), during the formation of a metal grid layer (7), the escaping nitrogen atoms or nitrogen ions react with the metal on sidewalls of second openings (7a), forming a metal nitride layer which protects the metal grid at the sidewalls of the second openings (7a) from being damaged. As such, the resulting metal grid layer (7) has smooth sidewalls and good morphology.

Abstract: The present invention provides a method for fabricating a semiconductor device, including the steps of: providing a pre-processed device including a dielectric layer, a metal layer embedded in the dielectric layer and a first substrate covering the dielectric layer, the dielectric layer including a first dielectric layer, an etch stop layer and a second dielectric layer that are sequentially deposited, wherein the metal layer is embedded in the first dielectric layer, and the etch stop layer is located over the metal layer; forming a mask layer on the first substrate; with the mask layer serving as a mask, etching the first substrate by performing a first etching process to expose the dielectric layer; still with the mask layer as a mask, etching the exposed second dielectric layer by performing a second etching process, which stops at the etch stop layer, to form an opening; forming an isolation layer, which covers at least a sidewall of the opening; and etching away the first dielectric layer under the open

Abstract: The present disclosure relates to benzimidazole derivatives, a preparation method therefor and a medical use thereof. Specifically, the present disclosure relates to a benzimidazole derivative represented by the general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, and its use as a therapeutic agent, in particular its use for the treatment of diseases related to P2X3 activity.

Abstract: The invention discloses a micro hydraulic suspension mechanical pump structure and an assembling method thereof. The hydraulic suspension micro pump includes a volute, an upper end cap, a positioning sheet, an impeller, a hollow cup motor, a waterproof cover, and a rotor. The hollow cup motor includes a motor casing, a motor bottom cap, a magnet rotor, a coil, and an iron core. The waterproof cover is in a separated state from the motor, and a lower part has a positioning boss to implement radial cooperation with a recess at a corresponding position of the motor. At the same time, there is the sheet between the recess and the boss to implement axial positioning of the waterproof cover.

Abstract: The invention discloses a micro hydraulic suspension mechanical pump structure and an assembling method thereof. The hydraulic suspension micro pump includes a volute, an upper end cap, a positioning sheet, an impeller, a hollow cup motor, a waterproof cover, and a rotor. The hollow cup motor includes a motor casing, a motor bottom cap, a magnet rotor, a coil, and an iron core. The waterproof cover is in a separated state from the motor, and a lower part has a positioning boss to implement radial cooperation with a recess at a corresponding position of the motor. At the same time, there is the sheet between the recess and the boss to implement axial positioning of the waterproof cover.

Abstract: Disclosed are a pyrimidine five-membered nitrogen heterocyclic derivative, a preparation method thereof and the pharmaceutical use thereof. Specifically disclosed are a pyrimidine five-membered nitrogen heterocyclic derivative represented by general formula (II), a preparation method thereof, a composition containing the derivative, and the use thereof as an SHP2 inhibitor and in the preparation of a medicament for preventing and/or treating tumors or cancer.

Abstract: Disclosed are compounds inhibiting ErbBs (e.g., EGFR or Her 2), especially mutant forms of ErbBs, and BTK, pharmaceutically acceptable salts, hydrates, solvates or stereoisomers thereof and pharmaceutical compositions comprising the compounds. The compound and the pharmaceutical composition can effectively treat ErbBs (especially mutant forms of ErbBs) or BTK associated diseases, including cancer.

Abstract: The present invention relates to a pyrimidine and a five-membered nitrogen heterocycle derivative, a preparation method therefor, and the medical uses thereof. Particularly, the present invention relates to a pyrimidine and a five-membered nitrogen heterocycle derivative represented by the general formula (I), a preparation method thereof, a pharmaceutical composition containing the derivative, and the uses thereof as a SHP2 inhibitor for use in the prevention and/or treatment of tumor or cancer, wherein each substituent in the general formula (I) is as defined in the description.

Abstract: A method, apparatus and computer program product for managing one or more groups of Machine-Type Communication (MTC) devices in a cellular network. According to one aspect, a method for managing one or more groups of Machine-Type Communication (MTC) devices in a cellular network includes an exposure function for exposing network capabilities and events detected by other network functions, characterized by the following steps carried out at the exposure function: —a) receiving, from an MTC application, a request for membership management on the one or more MTC groups, wherein the request includes corresponding one or more MTC group identifiers and an MTC device identifier for the MTC application; and —b) transmitting, towards a user profile server, a corresponding request for membership management, wherein the corresponding request includes the one or more MTC group identifiers, the MTC device identifier and a corresponding MTC application identifier.

Abstract: Disclosed are compounds inhibiting ErbBs (e.g., EGFR or Her 2), especially mutant forms of ErbBs, and BTK, pharmaceutically acceptable salts, hydrates, solvates or stereoisomers thereof and pharmaceutical compositions comprising the compounds. The compound and the pharmaceutical composition can effectively treat ErbBs (especially mutant forms of ErbBs) or BTK associated diseases, including cancer.

Abstract: Some embodiments are directed to the design and manufacture of integrated circuits, and more particularly, some embodiments are directed to the electrical modeling of integrated circuits combining high voltage power devices with low voltage control logic blocks, and even more particularly, some embodiments are directed to the modeling of substrate coupling effects in these circuits.

Abstract: Disclosed are compounds inhibiting ErbBs (e.g., EGFR or Her 2), especially mutant forms of ErbBs, and BTK, pharmaceutically acceptable salts, hydrates, solvates or stereoisomers thereof and pharmaceutical compositions comprising the compounds. The compound and the pharmaceutical composition can effectively treat ErbBs (especially mutant forms of ErbBs) or BTK associated diseases, including cancer.

Abstract: A method for preparing a polyolefin resin powder has the steps of a) heat dissolving a polyolefin resin in an organic solvent having a solubility parameter less than or equal to the solubility parameter of the polyolefin resin to obtain a polyolefin resin solution; b) cooling the polyolefin resin solution to precipitate a solid, thereby obtaining a solid-liquid mixture; c) optionally adding an adjuvant to the solid-liquid mixture and mixing; and d) conducting solid-liquid separation and drying to obtain a polyolefin resin powder suitable for selective laser sintering. The difference between the solubility parameters of the organic solvent and of the polyolefin resin is within 0-20% of the solubility parameter of the polyolefin resin. The polyolefin resin powder obtained according to this method has good antioxidant property, good powder flowability, moderate size, smooth surface, suitable bulk density, and suitable dispersibility and particle size distribution.

Abstract: Disclosed are compounds inhibiting ErbBs (e.g., EGFR or Her 2), especially mutant forms of ErbBs, and BTK, pharmaceutically acceptable salts, hydrates, solvates or stereoisomers thereof and pharmaceutical compositions comprising the compounds. The compound and the pharmaceutical composition can effectively treat ErbBs (especially mutant forms of ErbBs) or BTK associated diseases, including cancer.

Abstract: A method for preparing an aliphatic polyester resin powder includes the steps of a) heat dissolving a crystalline aliphatic polyester resin in an organic solvent to obtain an aliphatic polyester resin solution; b) cooling the aliphatic polyester resin solution to precipitate a solid, thereby obtaining a solid-liquid mixture; c) optionally adding an adjuvant to the solid-liquid mixture and mixing; and d) conducting solid-liquid separation and drying to obtain an aliphatic polyester resin powder suitable for selective laser sintering. The crystalline aliphatic polyester resin powder obtained has good antioxidant property, good powder flowability, moderate size, smooth surface, suitable bulk density, and suitable dispersibility and particle size distribution. The aliphatic polyester resin powder is particularly suitable for selective laser sintering method.

Abstract: An efficient, flexible P2P file transmission management technology for limiting and directing of P2P file transmission mainly by replacing an original tracker server with a setting controllable tracker server, and modifying node list based on predetermined rule in the controllable tracker server. With the present invention, a network operator can strengthen function of the controllable tracker server in P2P communication gradually by weakening function of the original tracker server in P2P communication gradually, and utilize various rules or policies established in advance to manage file transfer of P2P nodes.