Abstract: Disclosed is a nitrogen-containing heterocyclic compound, pharmaceutical compositions thereof and use thereof. The present disclosure provides a nitrogen-containing heterocyclic compound represented by formula I, a pharmaceutically acceptable salt thereof, a solvate thereof, a solvate of pharmaceutically acceptable salt thereof, a crystal thereof, a stereoisomer thereof, a tautomer thereof or an isotopically labeled compound thereof. The nitrogen-containing heterocyclic compound represented by formula I is expected to treat and/or prevent various PI3K-meditated diseases.

Abstract: A method for manufacturing a semiconductor structure includes: a base provided with a contact hole is provided; an initial contact structure including a first diffusion barrier layer, a conductive layer and a second diffusion barrier layer stacked onto one another is formed on the base, the first diffusion barrier layer conformably covering the contact hole and covering part of a top surface of the base, the conductive layer covering first diffusion barrier layer and being filled in unoccupied space in the contact hole, the second diffusion barrier layer covering a side of the conductive layer away from first diffusion barrier layer, the initial contact structure outside the contact hole being provided with a groove exposing side walls of conductive layer and second diffusion barrier layer; a third diffusion barrier layer is formed on a side wall of initial contact structure exposed by the groove to obtain a target contact structure.

Abstract: Disclosed in the present invention are a compound having a BRD4 inhibitory activity, a preparation method therefor and the use thereof. The structure of the compound having the BRD4 inhibitory activity of the present invention is as shown in formula I, and the definition of each substituent is as described in the description and claims. The compound of the present invention has a high bromodomain protein inhibitory activity, in particular a BRD4-targeting inhibitory activity, and can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.

Abstract: Disclosed are an information interaction method and apparatus, and an electronic device. One specific embodiment of the method comprises: in response to a user logging in to a live interface initiated based on a multimedia conference, displaying a live data stream of the multimedia conference in the live interface initiated based on the multimedia conference, wherein the live data stream is generated on the basis of an interactive data stream of a participating user of the multimedia conference; receiving interactive content input by the user on the basis of the live data stream, and generating interactive information according to the interactive content; and sending the interactive information to a serving end, so as to instruct the serving end to send the interactive information to a terminal device that displays the live interface. The communication efficiency of information related to the content of a multimedia conference is thus improved.

Abstract: Various embodiments include systems, methods, and non-transitory computer-readable media for identifying and matching influencers with categorized products using multimodal machine learning technologies. Consistent with these embodiments, a method includes identifying an influencer based on a set of criteria; determining a first attribute of the influencer based on context data associated with the influencer; identifying a second attribute of an item; generating a first vector that represents the first attribute of the influencer and a second vector that represents the second attribute of the item; generating a similarity score that represents a degree of similarity between the influencer and the item based on the first vector and the second vector; and causing display of the similarity score in a user interface of a device.

Abstract: A method and device for allocating a distributed lock is provided. A globally unique service process ID (SPI) is introduced for each distributed application service process while guaranteeing correctness of a distributed lock, and the SPI is used to directly manage ownership of the distributed lock. The service replacement process sends to the server a request for inheriting ownership of the distributed lock before the lifecycle of the lock file expires, the inherit request including the SPI.

Abstract: The invention relates to the field of pharmaceutical chemistry. Specifically, the present invention relates to a series of BET (bromodomain and extra-terminal domain) inhibitors having a novel structure, particularly inhibitors targeting BRD4 (Bromodomain-containing protein 4), and a preparation method and use therefor. The structure thereof is shown in the following general formula (I). Said compounds or a stereoisomer, racemate, geometric isomer, tautomer, prodrug, hydrate, solvate, or crystal form thereof, or a pharmaceutically acceptable salt thereof, and the pharmaceutical composition thereof can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.

Abstract: A method and device for allocating a distributed lock is provided. A globally unique service process ID (SPI) is introduced for each distributed application service process while guaranteeing correctness of a distributed lock, and the SPI is used to directly manage ownership of the distributed lock. The service replacement process sends to the server a request for inheriting ownership of the distributed lock before the lifecycle of the lock file expires, the inherit request including the SPI.

Abstract: This disclosure examines using lead telluride nanocrystals as well as other materials suitable for thermoelectric conversion, particularly materials with high Figure of Merit values, as coatings on flexible substrates.

Abstract: A nanoscale heterostructure tellurium-based nanowire structure, including a rod-like tellurium nanowire structure and a metal telluride agglomeration connected to the rod-like nanowire structure. The metal telluride agglomeration may have an octahedral shape or a platelet shape. The agglomeration structures are selected from the group comprising lead telluride, cadmium telluride, bismuth telluride, and combinations thereof.

Abstract: The principles of the present invention extend to accessing results of network diagnostic functions in a distributed system. A chassis allocates resources for performing a network diagnostic function directly to requesting computer system. The requesting computer system communicates directly with the allocated resources to initiate the network diagnostic function. The network diagnostic test continues to execute even if the requesting computer system subsequently malfunctions. Collected test results are stored at the chassis such that any network connectable computer system can access the collected test results. A monitoring computer system (which may or may not be the requesting computer system) requests collected test results corresponding to the network diagnostic function. The chassis identifies appropriate test results and returns the results to the monitoring computer system.