Patents by Inventor Haresh Digambar Patil
Haresh Digambar Patil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11566218Abstract: Cell culture apparatus is disclosed comprising: a cell culture container comprising a flexible tube; a support table; and a pair of opposed holders for holding opposed portions of the tube in a fluid tight manner such that fluid cannot pass through the respective portion inside the tube, the spacing between the said pair being adjustable to provide an adjustable sealed volume in the tube between the holder pair.Type: GrantFiled: June 22, 2017Date of Patent: January 31, 2023Assignee: Global Life Sciences Solutions USA LLCInventors: Nagaraju Konduru, Manoj Ramakrishna, Haresh Digambar Patil
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Patent number: 11452976Abstract: The present invention relates to a mixing system for a bioreactor, comprising a plurality of supply units (10), each being able to hold media for use in a bioreactor a mixing unit (30) for creating a uniform mixing of media a first feeding mechanism (20), arranged to feed media from the supply units (10) into the mixing unit (30), a control unit (40) operatively connected to the first feeding mechanism (20) and the mixing unit (30), said control unit (40) being configured to control the first feeding mechanism (20) to feed predetermined amounts of media from the plurality of supply units (10) to the mixing unit (30), and further being configured to control the mixing unit (30) to create a uniform mixing of media. The invention also relates to a method for mixing media for use in a bioreactor.Type: GrantFiled: December 22, 2017Date of Patent: September 27, 2022Assignee: Global Life Sciences Solutions USA LLCInventors: Manoj Ramakrishna, Sebastian John, Anoop Bhargav, Haresh Digambar Patil, Praveen Paul
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Patent number: 11326142Abstract: Disclosed is a biomanufacturing apparatus (1) comprising a housing (20) including top (22) and bottom (24) faces which allow stacking of plural housings, an access door (25) at a front side of the housing, a substantially enclosed bioreactor chamber (30) inside the housing accessible via the door, and a further substantially enclosed region (36) inside the housing containing electrical parts and/or electronic control components, the chamber (30) including: a tray (40/240) for supporting a bioreactor, a tray support (45/245) including a mechanism (44,47/244,247) for rocking the tray in use; the tray having complementary formations allowing movement of tray relative to the tray support toward the front side to allow more convenient access to the bioreactor.Type: GrantFiled: August 25, 2016Date of Patent: May 10, 2022Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Haresh Digambar Patil, Anoop Bhargav, Praveen Paul, Sebastian John
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Patent number: 10995310Abstract: Disclosed is biomanufacturing apparatus 1 comprising a housing 20 including top 22 and bottom 24 faces which allow stacking of plural housings, an access door 25 at a front side of the housing, a substantially enclosed bioreactor chamber 30 inside the housing accessible via the door, and a further substantially enclosed region 36 inside the housing containing electrical parts and/or electronic control components, the chamber 30 including: a tray 40 for supporting a bioreactor, a tray support 45 including a mechanism 44,47 for rocking the tray in use; the tray support further including a load cell (41) to determine changes in the mass load on the tray.Type: GrantFiled: August 25, 2016Date of Patent: May 4, 2021Assignee: Global Life Sciences Solutions USA LLCInventors: Praveen Paul, Manoj Ramakrishna, Anoop Bhargav, Haresh Digambar Patil, Sebastian John, Manish Uddhaorao Choudhary, Pradeep Kumar, Nivedita Phadke
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Patent number: 10995312Abstract: Disclosed is biomanufacturing apparatus 1 comprising a housing 20 including top 22 and bottom 24 faces which allow stacking of plural housings, an access door 25 at a front side of the housing, a substantially enclosed bioreactor chamber 30 inside the housing accessible via the door, and a further substantially enclosed region 36 inside the housing containing electrical parts and/or electronic control components, the chamber 30 including: a tray 40 for supporting a bioreactor, a tray support 45 including a mechanism 44,47 for rocking the tray in use; at least a fluid handling portion 48,49 of at least one fluid pump device 54/58; and at least one connection 43 for connecting to a conduit and/or path for carrying fluids, gas and/or electricity.Type: GrantFiled: August 25, 2016Date of Patent: May 4, 2021Assignee: Global Life Sciences Solutions USA LLCInventors: Haresh Digambar Patil, Praveen Paul, Manish Uddhaorao Choudhary, Pradeep Kumar, Anoop Bhargav, Sebastian John, Nivedita Phadke, Manoj Ramakrishna
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Patent number: 10934518Abstract: The present invention relates to a novel bioreactor system for cell cultivation. More specifically, the invention relates to a compact bioreactor system which has several integrated functions and enables small scale static culture as well as scale-up rocking culture in the same bioreactor. The bioreactor system comprises tray for positioning of a cell culture bag having adjustable volume, a lid covering the cell culture bag and provided with heating function, an integrated perfusion unit, an integrated cell loading unit, and an integrated unit for automatic cell culture sampling, wherein the bioreactor system is controlled by a single control unit. The invention also relates to a method of cell culture using the bioreactor system for culture of therapeutic cells.Type: GrantFiled: January 29, 2016Date of Patent: March 2, 2021Assignee: Global Life Sciences Solutions USA LLCInventors: Haresh Digambar Patil, Manoj Ramakrishna, Anoop Bhargav, Praveen Paul, Sebastian John, Swapnil Puranik
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Patent number: 10858622Abstract: The present invention provides a device and method for sampling from a cell culture bioreactor. The invention is useful where it is required to determine the cell count, provide a sample for off-line analyses or remove a sample while at the same time retain sterility of the sample for quality control (QC) assessment. The device of the invention allows for facile aseptic sampling at one or more instances in time during a cell expansion in a bioreactor.Type: GrantFiled: August 12, 2016Date of Patent: December 8, 2020Assignee: Global Life Sciences Solutions USA LLCInventors: Manoj Ramakrishna, Haresh Digambar Patil, Sebastian John
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Publication number: 20190388855Abstract: The present invention relates to a mixing system for a bioreactor, comprising a plurality of supply units (10), each being able to hold media for use in a bioreactor a mixing unit (30) for creating a uniform mixing of media a first feeding mechanism (20), arranged to feed media from the supply units (10) into the mixing unit (30), a control unit (40) operatively connected to the first feeding mechanism (20) and the mixing unit (30), said control unit (40) being configured to control the first feeding mechanism (20) to feed predetermined amounts of media from the plurality of supply units (10) to the mixing unit (30), and further being configured to control the mixing unit (30) to create a uniform mixing of media. The invention also relates to a method for mixing media for use in a bioreactor.Type: ApplicationFiled: December 22, 2017Publication date: December 26, 2019Inventors: Manoj Ramakrishna, Sebastian John, Anoop Bhargav, Haresh Digambar Patil, Praveen Paul
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Publication number: 20190309254Abstract: Cell culture apparatus is disclosed comprising: a cell culture container comprising a flexible tube; a support table; and a pair of opposed holders for holding opposed portions of the tube in a fluid tight manner such that fluid cannot pass through the respective portion inside the tube, the spacing between the said pair being adjustable to provide an adjustable sealed volume in the tube between the holder pair.Type: ApplicationFiled: June 22, 2017Publication date: October 10, 2019Inventors: Nagaraju Konduru, Manoj Ramakrishna, Haresh Digambar Patil
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Publication number: 20190309251Abstract: A tray configured to be provided on a base station of a bioreactor system, said tray comprising a bottom and surrounding side walls and being configured to hold a bioreactor bag, said bottom comprising at least two bottom parts, whereof one is a middle part of the bottom, wherein at least one of the bottom parts is movable into at least a first and a second position, wherein said first position provides the bottom parts substantially flush with each other providing a substantially plane bottom of the tray and said second position provides a bottom of the tray having a recessed middle part.Type: ApplicationFiled: October 26, 2017Publication date: October 10, 2019Applicant: General Electric CompanyInventors: Haresh Digambar PATIL, Anoop BHARGAV, Praveen PAUL, Sebastian JOHN
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Publication number: 20190017011Abstract: Disclosed is biomanufacturing apparatus 1 comprising a housing 20 including top 22 and bottom 24 faces which allow stacking of plural housings, an access door 25 at a front side of the housing, a substantially enclosed bioreactor chamber 30 inside the housing accessible via the door, and a further substantially enclosed region 36 inside the housing containing electrical parts and/or electronic control components, the chamber 30 including: a tray 40 for supporting a bioreactor, a tray support 45 including a mechanism 44,47 for rocking the tray in use; at least a fluid handling portion 48,49 of at least one fluid pump device 54/58; and at least one connection 43 for connecting to a conduit and/or path for carrying fluids, gas and/or electricity.Type: ApplicationFiled: August 25, 2016Publication date: January 17, 2019Applicant: General Electric CompanyInventors: Haresh Digambar Patil, Praveen Paul, Manish Uddhaorao Choudhary, Pradeep Kumar, Anoop Bhargav, Sebastian John, Nivedita Phadke, Manoj Ramakrishna
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Patent number: 10081135Abstract: An integrated system for fusing and sealing of a plurality of tubes is disclosed. The integrated system includes one or more fusing units configured to cut one or more tubes of multiple tubes simultaneously, and fusing the one or more tubes together along their respective cut ends; one or more sealing units configured to seal an end of the tube of the multiple tubes; and a control unit for controlling functions of the one or more fusing units and the one or more sealing units.Type: GrantFiled: February 19, 2015Date of Patent: September 25, 2018Assignee: GE HEALTHCARE BIO-SCIENCES ABInventors: Haresh Digambar Patil, Partha Sarathy Doddapadam Srinivasa Raghavachar, Ganesan Mariyappan, Prashanth Hosabettu Mohan
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Publication number: 20180250666Abstract: Disclosed is biomanufacturing apparatus (1) comprising a housing (20), a substantially enclosed bioreactor chamber (30) inside the housing and a further substantially enclosed region (36) inside the housing containing electrical parts and/or electronic control components, the chamber (30) including: a tray (40) for supporting a bioreactor, a tray support (45) including a mechanism (44,47) for rocking the tray in use the tray (40) including a heater (42) for contacting a bioreactor and heating the same, and the apparatus further comprising secondary heating (53) for heating air surrounding the tray.Type: ApplicationFiled: August 25, 2016Publication date: September 6, 2018Applicant: General Electric CompanyInventors: Praveen Paul, Manoj Ramakrishna, Anoop Bhargav, Haresh Digambar Patil, Sebastian John, Manish Uddhaorao Choudhary, Pradeep Kumar, Nivedita Phadke
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Publication number: 20180251715Abstract: Disclosed is biomanufacturing apparatus 1 comprising a housing 20 including top 22 and bottom 24 faces which allow stacking of plural housings, an access door 25 at a front side of the housing, a substantially enclosed bioreactor chamber 30 inside the housing accessible via the door, and a further substantially enclosed region 36 inside the housing containing electrical parts and/or electronic control components, the chamber 30 including: a tray 40 for supporting a bioreactor, a tray support 45 including a mechanism 44,47 for rocking the tray in use; the tray support further including a load cell (41) to determine changes in the mass load on the tray.Type: ApplicationFiled: August 25, 2016Publication date: September 6, 2018Applicant: General Electric CompanyInventors: Praveen Paul, Manoj Ramakrishna, Anoop Bhargav, Haresh Digambar Patil, Sebastian John, Manish Uddhaorao Choudhary, Pradeep Kumar, Nivedita Phadke
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Publication number: 20180251722Abstract: Disclosed is a biomanufacturing apparatus (1) comprising a housing (20) including top (22) and bottom (24) faces which allow stacking of plural housings, an access door (25) at a front side of the housing, a substantially enclosed bioreactor chamber (30) inside the housing accessible via the door, and a further substantially enclosed region (36) inside the housing containing electrical parts and/or electronic control components, the chamber (30) including: a tray (40/240) for supporting a bioreactor, a tray support (45/245) including a mechanism (44,47/244,247) for rocking the tray in use; the tray having complementary formations allowing movement of tray relative to the tray support toward the front side to allow more convenient access to the bioreactor.Type: ApplicationFiled: August 25, 2016Publication date: September 6, 2018Applicant: General Electric CompanyInventors: Haresh Digambar PATIL, Anoop BHARGAV, Praveen PAUL, Sebastian JOHN
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Publication number: 20180201894Abstract: The present invention provides a device and method for sampling from a cell culture bioreactor. The invention is useful where it is required to determine the cell count, provide a sample for off-line analyses or remove a sample while at the same time retain sterility of the sample for quality control (QC) assessment. The device of the invention allows for facile aseptic sampling at one or more instances in time during a cell expansion in a bioreactor.Type: ApplicationFiled: August 12, 2016Publication date: July 19, 2018Inventors: Manoj RAMAKRISHNA, Haresh Digambar PATIL, Sebastian JOHN
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Publication number: 20180002655Abstract: The present invention relates to a novel bioreactor system for cell cultivation. More specifically, the invention relates to a compact bioreactor system which has several integrated functions and enables small scale static culture as well as scale-up rocking culture in the same bioreactor. The bioreactor system comprises tray for positioning of a cell culture bag having adjustable volume, a lid covering the cell culture bag and provided with heating function, an integrated perfusion unit, an integrated cell loading unit, and an integrated unit for automatic cell culture sampling, wherein the bioreactor system is controlled by a single control unit. The invention also relates to a method of cell culture using the bioreactor system for culture of therapeutic cells.Type: ApplicationFiled: January 29, 2016Publication date: January 4, 2018Inventors: Haresh Digambar Patil, Manoj Ramakrishna, Anoop Bhargav, Praveen Paul, Sebastian John, Swapnil Puranik
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Publication number: 20170113402Abstract: An integrated system for fusing and sealing of a plurality of tubes is disclosed. The integrated system includes one or more fusing units configured to cut one or more tubes of multiple tubes simultaneously, and fusing the one or more tubes together along their respective cut ends; one or more sealing units configured to seal an end of the tube of the multiple tubes; and a control unit for controlling functions of the one or more fusing units and the one or more sealing units.Type: ApplicationFiled: February 19, 2015Publication date: April 27, 2017Inventors: Haresh Digambar Patil, Partha Sarathy Doddapadam Srinivasa Raghavachar, Ganesan Mariyappan, Prashanth Hosabettu Mohan
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Patent number: D776825Type: GrantFiled: February 10, 2016Date of Patent: January 17, 2017Assignee: General Electric CompanyInventors: Haresh Digambar Patil, Praveen Paul, Manish Uddhaorao Choudhary