Patents by Inventor Harold A. Karnes

Harold A. Karnes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DEUTERATED FORMS OF AMINOSTEROLS AND METHODS OF USING THE SAME
    Publication number: 20200262864
    Abstract: Described are deuterated forms of aminosterols, or a pharmaceutically acceptable salt thereof, wherein one or more hydrogen atoms at one or more positions selected from C1, C2, C3, C4, C5, C6, C7, C8, C9, C11, C12, C14, C15, C16, C17, C18, C19, C20, C21, C22, C23, C24, C25, C26, and C27, are replaced with deuterium.
    Type: Application
    Filed: February 19, 2020
    Publication date: August 20, 2020
    Applicant: Enterin, Inc.
    Inventors: Denise Barbut, Michael Zasloff, William A. Kinney, Stephen Jones, Scott Ashford, Anton Bieliauskas, Edward Hessler, Tom Fevig, Harold Karnes
  • Nitroso compounds to treat ischemia
    Publication number: 20050113573
    Abstract: The invention includes piperazinyl pyrimidinyl nitroso compounds of the formula (II) and N-Nitrosometoprolol and pharmaceutically acceptable salts thereof which are useful in treating one or more of the following ischemic diseases, coronary heart disease, stroke, hemorrhagic shock, peripheral vascular disease (of both the upper and lower extremities), abdominal vascular insufficiency and transplant related surgery.
    Type: Application
    Filed: November 21, 2003
    Publication date: May 26, 2005
    Inventors: Luis Toledo, Edward Hessler, Harold Karnes
  • Imidazolylpiperazinyl steroids
    Patent number: 5506354
    Abstract: Disclosed are amino substituted steroids (XI) which contain an imidazolylpiperazinyl group attached to the terminal carbon atom of the C.sub.17 -side chain which are useful as pharmaceutical agents for treating a number of conditions.
    Type: Grant
    Filed: December 1, 1992
    Date of Patent: April 9, 1996
    Assignee: The Upjohn Company
    Inventors: John M. McCall, Donald E. Ayer, E. Jon Jacobsen, Frederick J. VanDoornik, John R. Palmer, Harold A. Karnes
  • Triazinylpiperazinyl steroids
    Patent number: 5380840
    Abstract: Disclosed are amino substituted steroids (XI) which contain 4-[1,3,5-triazin-2-yl]- or 4-[1,2,4-triazin-3-yl]- 1-piperazinyl group attached to the terminal carbon atom of the C.sub.17 -side chain which are useful as pharmaceutical agents for treating a number of conditions.
    Type: Grant
    Filed: December 1, 1992
    Date of Patent: January 10, 1995
    Assignee: The Upjohn Company
    Inventors: John M. McCall, Donald E. Ayer, E. Jon Jacobsen, Frederick J. Van Doornik, John R. Palmer, Harold A. Karnes
  • Pyridinylpiperazinyl steroids
    Patent number: 5380841
    Abstract: Disclosed are amino substituted steroids (XI) which contain a pyridinylpiperazinyl group group attached to the terminal carbon atom of the C.sub.17 -side chain of the steroid which are useful as pharmaceutical agents for treating a number of conditions.
    Type: Grant
    Filed: December 1, 1992
    Date of Patent: January 10, 1995
    Assignee: The Upjohn Company
    Inventors: John M. McCall, Donald E. Ayer, E. Jon Jacobsen, Frederick J. VanDoornik, John R. Palmer, Harold A. Karnes
  • Triazinylpiperazinyl amine intermediates
    Patent number: 5268477
    Abstract: The claimed invention is to triazin-2-yl and triazin-3-yl piperazines which are useful intermediates in the preparation of amino substituted steroid (XI) which are useful pharmaceutical agents.
    Type: Grant
    Filed: November 19, 1992
    Date of Patent: December 7, 1993
    Assignee: The Upjohn Company
    Inventors: John M. McCall, Donald E. Ayer, E. Jon Jacobsen, Frederick J. VanDoornik, John R. Palmer, Harold A. Karnes
  • Pharmaceutically active pyrimidinylpiperazinylsterioids
    Patent number: 5175281
    Abstract: Disclosed are .DELTA..sup.9(11) -steroids (VI) and amino substituted steroids (XI) which contain an amino group attached to the terminal carbon atom of the C.sub.17 -side chain, more particularly amino steroids (Ia and Ib), aromatic steroids (II), .DELTA..sup.16 -steroids (IIIa and IIIb), reduced A-ring steroids (IV), .DELTA..sup.17(20) -steroids (Va and Vb) and .DELTA..sup.9(11) -steroids (VI) which are useful as pharmaceutical agents for treating a number of conditions.
    Type: Grant
    Filed: August 26, 1991
    Date of Patent: December 29, 1992
    Assignee: The Upjohn Company
    Inventors: John M. McCall, Donald E. Ayer, E. Jonathan Jacobsen, Frederick J. VanDoornik, John R. Palmer, Harold A. Karnes
  • Amines useful in producing pharmaceutically active CNS compounds
    Patent number: 5099019
    Abstract: Disclosed are .DELTA..sup.9(11) -steroids (VI) and amino substituted steroids (XI) which contain an amino group attached to the terminal carbon atom of the C.sub.17 -side chain, more particularly amino steroids (Ia and Ib), aromatic steroids (II), .DELTA..sup.16 -steroids (IIIa and IIIb), reduced A-ring steroids (IV), .DELTA..sup.17(20) -steroids (Va and Vb) and .DELTA..sup.9(11) -steroids (VI) which are useful as pharmaceutical agents for treating a number of conditions.
    Type: Grant
    Filed: August 8, 1988
    Date of Patent: March 24, 1992
    Assignee: Upjohn Company
    Inventors: John M. McCall, Donald E. Ayer, E. Jonathan Jacobsen, Frederick J. VanDoornik, John R. Palmer, Harold A. Karnes