Abstract: The present disclosure provides methods and systems for classifying microsatellite and minor alleles in a sample. Also, the present disclosure provides methods and systems for generating classifiers for conditions based on microsatellite loci and for performing pan-cancer assays. The methods and systems can involve next-generation sequencing of nucleic acid samples from subjects and genotyping microsatellite loci in the samples.

Abstract: A system implemented on a distributed computer network for capturing experiences of healthcare trainees. The system includes input devices having an interface for interacting with a user including an input screen having data input fields, selection fields and activation buttons and output screens. Also included are one or more back-end databases configured to store input data from the input devices and to provide output data to the input devices.

Abstract: A system implemented on a distributed computer network for capturing experiences of healthcare trainees. The system includes input devices having an interface for interacting with a user including an input screen having data input fields, selection fields and activation buttons and output screens. Also included are one or more back-end databases configured to store input data from the input devices and to provide output data to the input devices.

Abstract: Prognostic and diagnostic methods based on somatic microsatellite variability measurements are described. Somatic microsatellite variability measurements can be used to identify defects in DNA repair pathways in a biological sample and to predict or identify one or more pathologies. The methods may statistically compare somatic microsatellite variability between a sample from a cell line or subject with that of a reference sample with defined pathological characteristics and/or defined lesions in DNA repair pathways. The methods are useful for determining the probability that an individual may develop a pathology, such as a cancer, within a specific time frame, and/or are useful as a diagnostic test. The methods have clinical utility in that somatic variability can be evaluated and/or measured as an indication of the amount of genomic instability (e.g., microsatellite and non-microsatellite/SNP), which can then be used as a clinical diagnostic to make clinical decisions, especially in the area of cancer.

Abstract: Vehicle playsets having multiple configurations. The vehicle playsets may include a track segment, a trigger adjacent to the track segment, a moving component adapted to move toward the trigger, and a launch mechanism coupled to the track segment and adapted to launch a toy vehicle along the track segment toward the moving component. Striking the moving component with the toy vehicle may prevent the moving component from reaching the trigger. The playset may include at least two configurations including a closed configuration and an open configuration that is suitable for play.

Abstract: An indexing stunt selector for a toy vehicle track set is provided. The indexing stunt selector may be disposed along a toy vehicle track and includes a first stunt element disposed in the vehicle pathway to cause a toy vehicle to perform a first stunt, where performance of a first stunt results in actuation of a first stunt trigger. The indexing stunt selector further includes a second stunt element adapted to be automatically disposed in the vehicle pathway following actuation of the first stunt trigger.

Abstract: Vehicle playsets having multiple configurations. The vehicle playsets may include a track segment, a trigger adjacent to the track segment, a moving component adapted to move toward the trigger, and a launch mechanism coupled to the track segment and adapted to launch a toy vehicle along the track segment toward the moving component. Striking the moving component with the toy vehicle may prevent the moving component from reaching the trigger. The playset may include at least two configurations including a closed configuration and an open configuration that is suitable for play.

Abstract: Vehicle playsets having multiple configurations. The vehicle playsets may include a track segment, a trigger adjacent to the track segment, a moving component adapted to move toward the trigger, and a launch mechanism coupled to the track segment and adapted to launch a toy vehicle along the track segment toward the moving component. Striking the moving component with the toy vehicle will prevent the moving component from reaching the trigger. The playset has at least two configurations including a closed configuration and an open configuration that is suitable for play.

Abstract: An indexing stunt selector for a toy vehicle track set is provided. The indexing stunt selector may be disposed along a toy vehicle track and includes a first stunt element disposed in the vehicle pathway to cause a toy vehicle to perform a first stunt, where performance of a first stunt results in actuation of a first stunt trigger. The indexing stunt selector further includes a second stunt element adapted to be automatically disposed in the vehicle pathway following actuation of the first stunt trigger.

Abstract: An indexing stunt selector for a toy vehicle track set is provided. The indexing stunt selector may be disposed along a toy vehicle track and includes a first stunt element disposed in the vehicle pathway to cause a toy vehicle to perform a first stunt, where performance of a first stunt results in actuation of a first stunt trigger. The indexing stunt selector further includes a second stunt element adapted to be automatically disposed in the vehicle pathway following actuation of the first stunt trigger.

Abstract: A toy ramp device for two or more moveable objects is disclosed. In some embodiments, the toy ramp device may include a base; a ramp configured to support at least a first of the two or more moveable objects and including a first ramp end portion and a second ramp end portion, the ramp being movably connected to the base and configured to move among a plurality of positions relative to the base; and a holder mechanism attached to the ramp and configured to support at least one of the two or more moveable objects adjacent to the ramp when the ramp is in the first position, and to allow the at least one of the two or more moveable objects to move onto the ramp and move along the ramp toward the second ramp end portion when the ramp is in the second position.

Abstract: Toy raceways and finish line apparatuses for toy raceways are disclosed. Toy raceways may include a plurality of hingedly coupled multi-lane track segments, a starting apparatus, and a finish line apparatus. The plurality of hingedly coupled multi-lane track segments may be configured to foldably transition between a first configuration and a second configuration. In the first configuration, the plurality of hingedly coupled multi-lane track segments may be aligned to provide a multilane toy raceway, which may have a first end and a second end. In the second configuration, the plurality of hingedly coupled multi-lane track segments may produce a stack of folded track segments. The starting apparatus may be disposed proximate the first end of the toy raceway, and the finish line apparatus may be disposed proximate the second end of the toy raceway.

Abstract: A method, computer program product and system for analyzing multispectral images from a plurality of regions of birefringent material, such as a polymer film, using polarized light and a corresponding polar analyzer to identify differential strain in the birefringent material. For example, the birefringement material may be low-density polyethylene (LDPE), high-density polyethylene (HDPE), polypropylene, polyethylene terephthalate (PET), polyvinyl chloride (PVC), polyvinylidene chloride, polyester, nylon, or cellophane film. Optionally, the method includes generating a real-time quantitative strain map.

Abstract: Vehicle playsets having multiple configurations. The vehicle playsets may include a track segment, a trigger adjacent to the track segment, a moving component adapted to move toward the trigger, and a launch mechanism coupled to the track segment and adapted to launch a toy vehicle along the track segment toward the moving component. Striking the moving component with the toy vehicle will prevent the moving component from reaching the trigger. The playset has at least two configurations including a closed configuration and an open configuration that is suitable for play.

Abstract: Toy raceways and finish line apparatuses for toy raceways are disclosed. Toy raceways may include a plurality of hingedly coupled multi-lane track segments, a starting apparatus, and a finish line apparatus. The plurality of hingedly coupled multi-lane track segments may be configured to foldably transition between a first configuration and a second configuration. In the first configuration, the plurality of hingedly coupled multi-lane track segments may be aligned to provide a multilane toy raceway, which may have a first end and a second end. In the second configuration, the plurality of hingedly coupled multi-lane track segments may produce a stack of folded track segments. The starting apparatus may be disposed proximate the first end of the toy raceway, and the finish line apparatus may be disposed proximate the second end of the toy raceway.

Abstract: A toy ramp device for two or more moveable objects is disclosed. In some embodiments, the toy ramp device may include a base; a ramp configured to support at least a first of the two or more moveable objects and including a first ramp end portion and a second ramp end portion, the ramp being movably connected to the base and configured to move among a plurality of positions relative to the base; and a holder mechanism attached to the ramp and configured to support at least one of the two or more moveable objects adjacent to the ramp when the ramp is in the first position, and to allow the at least one of the two or more moveable objects to move onto the ramp and move along the ramp toward the second ramp end portion when the ramp is in the second position.

Abstract: An indexing stunt selector for a toy vehicle track set is provided. The indexing stunt selector may be disposed along a toy vehicle track and includes a first stunt element disposed in the vehicle pathway to cause a toy vehicle to perform a first stunt, where performance of a first stunt results in actuation of a first stunt trigger. The indexing stunt selector further includes a second stunt element adapted to be automatically disposed in the vehicle pathway following actuation of the first stunt trigger.

Abstract: An apparatus and method for catalyzing a reaction on a substrate (24) comprising, a light source (12), a micromirror (16) positioned to redirect light (14) from the light source (12) toward a substrate (24) wherein the redirected light (14) catalyzes a chemical reaction proximate a substrate (24), is disclosed. A computer (18) is connected to, and controls, the positioning of mirrors within the micromirror (16) to specifically redirect light to specific portions of a substrate. The substrate (24) can be placed in a reaction chamber (50), wherein the light (14) that is redirected by the micromirror (16) catalyzes a chemical reaction proximate a substrate (24).

Abstract: The present invention relates to an apparatus and method for displaying three-dimensional images. The device of the present invention displays a holographic transform reflected from a light modulation device onto an active image reconstructor to create real-time, three-dimensional moving holograms from a single light beam.

Abstract: A pivotal jumping stick with the handlebars and footrest connected together and pivoted at their centers to permit the user to maintain his balance on uneven terrain. While in motion, a pin slides vertically in a slot formed in the impacting rod, counteracting the inherent twisting force of the spring mechanism, and allowing the user to accurately steer the device.