Abstract: Provided are methods and combinations for treating and/or preventing dry eye disease (DED) by treating a subject in need thereof with a combination of at least one parasympathetic agent at least one anti-sympathetic effective to treat said dry eye disease.

Abstract: Provided herein is a short-term myocardial infarction based test for identifying a compound, substance or drug that reduces the risk of myocardial infarction and optionally ischemic heart disease in a test subject(s). Further provided is a method for preventing or treating myocardial infarction using the compound, substance or drug identified.

Abstract: Provided herein is a short-term myocardial infarction based test for identifying a compound, substance or drug that reduces the risk of myocardial infarction and optionally ischemic heart disease in a test subject(s). Further provided is a method for preventing or treating myocardial infarction using the compound, substance or drug identified.

Abstract: Methods and compositions are provided for reducing the risk of adverse cardiovascular (CV) events associated with the administration of artificial blood. The methods involve the administration of a composition comprising artificial blood and one or more preventative pharmaceutical agents for reducing the risk of adverse CV events. In specific embodiments, an agent is selected from the group consisting of hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins), angiotensin converting enzyme (ACE) inhibitors, aspirin, corticosteroids, PPAR agents, and vasodilators. Kits for administering artificial blood together with one or more pharmaceutical agents that reduce the risk of adverse CV events are also provided.

Abstract: A quick-open blister package comprises a base member and a blistered containment member peripherally secured to the base member. The base member is frangible substantially along a plane contained therewithin, and first and second series of score lines extending at least in part about the periphery of the blister are cut into the base member substantially to the depth of the plane of frangibility. The blister is secured to the base member within that area thereof which is defined by the series of score lines. A considerable area of the base member can extend laterally of the blister for front printing.