Abstract: Systems and methods are disclosed to determine one or more sensing zones on a body surface for electrocardiographic mapping of a region of interest associated with the heart. The sensing zone can be utilized to facilitate acquisition, processing and mapping of electrical activity for the corresponding region of interest. In other examples, an application-specific arrangement of electrodes can also be provided based on the sensing zone that is determined for the region of interest.

Abstract: Systems and methods are disclosed to determine one or more sensing zones on a body surface for electrocardiographic mapping of a region of interest associated with the heart. The sensing zone can be utilized to facilitate acquisition, processing and mapping of electrical activity for the corresponding region of interest. In other examples, an application-specific arrangement of electrodes can also be provided based on the sensing zone that is determined for the region of interest.

Abstract: An electrophysiology system including signal channels each of which processes an electrophysiological signal along a signal path extending from an input port that receives the analog electrophysiological signal, via an adjustable gain element that amplifies the electrophysiological signal, and via an ADC element that converts the analog signal into a corresponding digital signal, to an output port. The system further includes a monitoring element that generates a monitoring signal representative of a DC component of the electrophysiological signal and a gain control element that generates a control signal responsive to the monitoring signal. The control signal controls the gain setting of the gain element to cause a decrease in gain, if an increase in the magnitude of the DC component is determined; and/or an increase in gain, if a decrease in the magnitude of the DC component is determined.

Abstract: Systems and methods can be used to provide an indication of heart function, such as an indication of mechanical function or hemodynamics of the heart, based on electrical data. For example, a method for assessing a function of the heart can include determining a time-based electrical characteristic for a plurality of points distributed across a spatial region of the heart. The plurality of points can be grouped into at least two subsets of points based on at least one of a spatial location for the plurality of points or the time-based electrical characteristics for the plurality of points. An indication of synchrony for the heart can be quantified based on relative analysis of the determined time-based electrical characteristic for each of the at least two subsets of points.

Abstract: An isolation amplification circuit having an input stage circuitry and a control circuitry stage interconnected through a galvanic isolation barrier. The input stage circuitry includes a first filter network and a second filter network for supplying first and second output signals in response to the application of first and second electrical input signals. The input stage circuitry includes a first feedback path configured for applying a first feedback signal to a common node of the first filter network to close a first feedback loop around the first filter network and a second feedback path configured for applying a second feedback signal to a common node of the second filter network to close a second feedback loop around the second filter network.

Abstract: Systems and methods are disclosed to determine one or more sensing zones on a body surface for electrocardiographic mapping of a region of interest associated with the heart. The sensing zone can be utilized to facilitate acquisition, processing and mapping of electrical activity for the corresponding region of interest. In other examples, an application-specific arrangement of electrodes can also be provided based on the sensing zone that is determined for the region of interest.

Abstract: Systems and methods are disclosed to determine one or more sensing zones on a body surface for electrocardiographic mapping of a region of interest associated with the heart. The sensing zone can be utilized to facilitate acquisition, processing and mapping of electrical activity for the corresponding region of interest. In other examples, an application-specific arrangement of electrodes can also be provided based on the sensing zone that is determined for the region of interest.

Abstract: A switchable filter device for use in a system for recording electro-physiological signals. The filter device includes a plurality of recording channels, the recording channels having an ablation recording channel. Each recording channel has a patient side terminal at a patient interface and a corresponding recording side terminal at a recording device interface. Each recording channel includes a first signal path with a first frequency dependent transmission characteristic having a first pass band, a second signal path with a second frequency dependent transmission characteristic different from the first frequency dependent transmission characteristic, the second frequency dependent transmission characteristic having a second pass band overlapping the first pass band, and switching devices operable to switch between the first signal path and the second signal path in response to a control signal indicative of a transient interference signal.

Abstract: An isolation amplification circuit having an input stage circuitry and a control circuitry stage interconnected through a galvanic isolation barrier. The input stage circuitry includes a first filter network and a second filter network for supplying first and second output signals in response to the application of first and second electrical input signals. The input stage circuitry includes a first feedback path configured for applying a first feedback signal to a common node of the first filter network to close a first feedback loop around the first filter network and a second feedback path configured for applying a second feedback signal to a common node of the second filter network to close a second feedback loop around the second filter network.

Abstract: An electrophysiology system including signal channels each of which processes an electrophysiological signal along a signal path extending from an input port that receives the analog electrophysiological signal, via an adjustable gain element that amplifies the electrophysiological signal, and via an ADC element that converts the analog signal into a corresponding digital signal, to an output port. The system further includes a monitoring element that generates a monitoring signal representative of a DC component of the electrophysiological signal and a gain control element that generates a control signal responsive to the monitoring signal. The control signal controls the gain setting of the gain element to cause a decrease in gain, if an increase in the magnitude of the DC component is determined; and/or an increase in gain, if a decrease in the magnitude of the DC component is determined.

Abstract: Systems and methods can be used to provide an indication of heart function, such as an indication of mechanical function or hemodynamics of the heart, based on electrical data. For example, a method for assessing a function of the heart can include determining a time-based electrical characteristic for a plurality of points distributed across a spatial region of the heart. The plurality of points can be grouped into at least two subsets of points based on at least one of a spatial location for the plurality of points or the time-based electrical characteristics for the plurality of points. An indication of synchrony for the heart can be quantified based on relative analysis of the determined time-based electrical characteristic for each of the at least two subsets of points.

Abstract: Systems and methods can be used to provide an indication of heart function, such as an indication of mechanical function or hemodynamics of the heart, based on electrical data. For example, a method for assessing a function of the heart can include determining a time-based electrical characteristic for a plurality of points distributed across a spatial region of the heart. The plurality of points can be grouped into at least two subsets of points based on at least one of a spatial location for the plurality of points or the time-based electrical characteristics for the plurality of points. An indication of synchrony for the heart can be quantified based on relative analysis of the determined time-based electrical characteristic for each of the at least two subsets of points.

Abstract: The present invention relates to a switchable filter device for use in a system for recording electro-physiological signals. The filter device comprises a plurality of recording channels, the recording channels comprising an ablation recording channel. Each recording channel has a patient side terminal at a patient interface and a corresponding recording side terminal at a recording device interface. Each recording channel comprises a first signal path with a first frequency dependent transmission characteristic having a first pass band, a second signal path with a second frequency dependent transmission characteristic different from the first frequency dependent transmission characteristic, the second frequency dependent transmission characteristic having a second pass band overlapping the first pass band, and switching devices operable to switch between the first signal path and the second signal path in response to a control signal indicative of a transient interference signal.

Abstract: A system (10) can localize an object in a patient's body. The system (10) can include a pulse generator (18 or 30) configured to provide a localization signal to at least one electrode that is fixed to the object in the patient's body. A sensor array (22) can be configured to detect an electrical field produced in response to the localization signal and provide respective sensor signals. A map generator (42) can be configured to reconstruct electrical signals based on the respective sensor signals and geometry data representing a geometric relationship between patient anatomy and the sensor array. A location calculator (50) can determine a location where the localization signal was applied based on the reconstructed electrical signals.

Abstract: This disclosure provides isolation for a medical amplifier by providing a low impedance path for noise across an isolation barrier. The low impedance path can include a capacitive coupling between a patient ground, which is isolated from control circuitry, and a functional ground of an isolation system that is isolated from earth ground. The low impedance path can draw noise current from an input of an amplifier of patient circuitry.

Abstract: This disclosure provides isolation for a medical amplifier by providing a low impedance path for noise across an isolation barrier. The low impedance path can include a capacitive coupling between a patient ground, which is isolated from control circuitry, and a functional ground of an isolation system that is isolated from earth ground. The low impedance path can draw noise current from an input of an amplifier of patient circuitry.

Abstract: Systems and methods can be used to provide an indication of heart function, such as an indication of mechanical function or hemodynamics of the heart, based on electrical data. For example, a method for assessing a function of the heart can include determining a time-based electrical characteristic for a plurality of points distributed across a spatial region of the heart. The plurality of points can be grouped into at least two subsets of points based on at least one of a spatial location for the plurality of points or the time-based electrical characteristics for the plurality of points. An indication of synchrony for the heart can be quantified based on relative analysis of the determined time-based electrical characteristic for each of the at least two subsets of points.

Abstract: This disclosure provides isolation for a medical amplifier by providing a low impedance path for noise across an isolation barrier. The low impedance path can include a capacitive coupling between a patient ground, which is isolated from control circuitry, and a functional ground of an isolation system that is isolated from earth ground. The low impedance path can draw noise current from an input of an amplifier of patient circuitry.

Abstract: Systems and methods can be used to provide an indication of heart function, such as an indication of mechanical function or hemodynamics of the heart, based on electrical data. For example, a method for assessing a function of the heart can include determining a time-based electrical characteristic for a plurality of points distributed across a spatial region of the heart. The plurality of points can be grouped into at least two subsets of points based on at least one of a spatial location for the plurality of points or the time-based electrical characteristics for the plurality of points. An indication of synchrony for the heart can be quantified based on relative analysis of the determined time-based electrical characteristic for each of the at least two subsets of points.

Abstract: A method can include providing at least one parameter to control a therapy that is applied to at least one internal anatomical structure of a patient. Electrical data can be obtained from the patient, including electrical data acquired via a plurality of sensors during each of a plurality of iterations of the therapy. The electrical data can be analyzed for a respective value of the at least one parameter of the therapy at each of the plurality of iterations of the applied therapy to compute an indication of at least one function of the at least one internal anatomical structure of the patient at each respective iteration of the applied therapy. The computed indication can be stored in memory. At least one parameter of the therapy can be adjusted for delivery in a subsequent one of the plurality of iterations based on the indication of the at least one function.