Patents by Inventor Harrison C. Brown

Harrison C. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cas9 nucleic acid molecules and their use
    Patent number: 11634726
    Abstract: Described are recombinant nucleic acid molecules for increased expression of Cas9 in human liver. In some embodiments, the recombinant nucleic acid molecules are provided in compositions and methods for gene editing, specifically using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR).
    Type: Grant
    Filed: June 8, 2020
    Date of Patent: April 25, 2023
    Assignee: Emory University
    Inventors: Christopher B. Doering, H. Trent Spencer, Harrison C. Brown
  • COMPOSITIONS AND METHODS FOR PROMOTING HEMATOPOIETIC CELL CYTOTOXICITY
    Publication number: 20220378827
    Abstract: Provided herein are compositions and methods for promoting hematopoietic cell cytotoxicity.
    Type: Application
    Filed: April 12, 2020
    Publication date: December 1, 2022
    Applicants: EMORY UNIVERSITY, CHILDREN'S HEALTHCARE OF ATLANTA, INC., EXPRESSION THERAPEUTICS LLC
    Inventors: Harold Trent Spencer, Christopher Doering, Shanmuganathan Chandrakasan, Lauren Fleischer, Jaquelyn Zoine, Gianna Branella, Harrison C. Brown
  • RECOMBINANT PROMOTERS AND VECTORS FOR PROTEIN EXPRESSION IN LIVER AND USE THEREOF
    Publication number: 20210128751
    Abstract: Disclosed herein are recombinant viral vectors comprising a liver specific promotor in operable combination with a heterologous nucleic acid sequence encoding a protein, such as a clotting factor. Methods of treating a subject with a clotting disorder, such as hemophilia A or hemophilia B, are also provided.
    Type: Application
    Filed: January 6, 2021
    Publication date: May 6, 2021
    Applicants: Emory University, Children's Healthcare of Atlanta, Inc.
    Inventors: Christopher B. Doering, H. Trent Spencer, Harrison C. Brown
  • Recombinant promoters and vectors for protein expression in liver and use thereof
    Patent number: 10898588
    Abstract: Disclosed herein are recombinant viral vectors comprising a liver specific promotor in operable combination with a heterologous nucleic acid sequence encoding a protein, such as a clotting factor. Methods of treating a subject with a clotting disorder, such as hemophilia A or hemophilia B, are also provided.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: January 26, 2021
    Assignees: Emory University, Children's Healthcare of Atlanta, Inc.
    Inventors: Christopher B. Doering, H. Trent Spencer, Harrison C. Brown
  • CAS9 NUCLEIC ACID MOLECULES AND THEIR USE
    Publication number: 20200299722
    Abstract: Described are recombinant nucleic acid molecules for increased expression of Cas9 in human liver. In some embodiments, the recombinant nucleic acid molecules are provided in compositions and methods for gene editing, specifically using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR).
    Type: Application
    Filed: June 8, 2020
    Publication date: September 24, 2020
    Applicant: Emory University
    Inventors: Christopher B. Doering, H. Trent Spencer, Harrison C. Brown
  • CAS9 nucleic acid molecules and their use
    Patent number: 10724050
    Abstract: Described are recombinant nucleic acid molecules for increased expression of Cas9 in human liver. In some embodiments, the recombinant nucleic acid molecules are provided in compositions and methods for gene editing, specifically using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR).
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: July 28, 2020
    Assignee: Emory University
    Inventors: Christopher B. Doering, H. Trent Spencer, Harrison C. Brown
  • RECOMBINANT PROMOTERS AND VECTORS FOR PROTEIN EXPRESSION IN LIVER AND USE THEREOF
    Publication number: 20180344877
    Abstract: Disclosed herein are recombinant viral vectors comprising a liver specific promotor in operable combination with a heterologous nucleic acid sequence encoding a protein, such as a clotting factor. Methods of treating a subject with a clotting disorder, such as hemophilia A or hemophilia B, are also provided.
    Type: Application
    Filed: August 8, 2018
    Publication date: December 6, 2018
    Applicants: Emory University, Children's Healthcare of Atlanta, Inc.
    Inventors: Christopher B. Doering, H. Trent Spencer, Harrison C. Brown
  • Recombinant promoters and vectors for protein expression in liver and use thereof
    Patent number: 10058624
    Abstract: Disclosed herein are recombinant viral vectors comprising a liver specific promotor in operable combination with a heterologous nucleic acid sequence encoding a protein, such as a clotting factor. Methods of treating a subject with a clotting disorder, such as hemophilia A or hemophilia B, are also provided.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: August 28, 2018
    Assignees: Emory University, Children's Healthcare of Atlanta, Inc.
    Inventors: Christopher B. Doering, H. Trent Spencer, Harrison C. Brown
  • RECOMBINANT PROMOTERS AND VECTORS FOR PROTEIN EXPRESSION IN LIVER AND USE THEREOF
    Publication number: 20170326256
    Abstract: Disclosed herein are recombinant viral vectors comprising a liver specific promotor in operable combination with a heterologous nucleic acid sequence encoding a protein, such as a clotting factor. Methods of treating a subject with a clotting disorder, such as hemophilia A or hemophilia B, are also provided.
    Type: Application
    Filed: April 15, 2016
    Publication date: November 16, 2017
    Applicants: Emory University, Children's Healthcare of Atlanta, Inc.
    Inventors: Christopher B. Doering, H. Trent Spencer, Harrison C. Brown