Abstract: In one example aspect, a computer-implemented method includes receiving biometrics data for a user; determining, based on the biometrics data, a baseline root-mean square (RMS) value prior to performance of a medical maneuver by the user; determining a minimum RMS value of the biometrics data during the medical maneuver; calculating a ratio between the minimum RMS value and the baseline RMS value to generate a minimum RMS ratio; and storing or outputting the minimum RMS ratio.

Abstract: Featured are methods and systems for assessing cardiac filing pressure non-invasively. Such methods include, inter alia, arranging a photoplethysmography (PPG) transducer on a finger of a patient and fluidly coupling a pressure transducer to the patient's mouth so that the pressure transducer measures expiratory pressure. The PPG transducer provides an output of a pulse volume signal of cardiac circulatory flow. Such methods also including determining a pulse amplitude ratio, using the pulse volume near the end of the expiratory effort and a baseline pulse volume, and assessing the pulse amplitude ratio so as to determine a filing pressure condition for the heart of the patient.

Abstract: Featured are methods for non-invasive assessment of a vascular physiological parameter including but not limited to central arterial stiffness, vascular reactivity and/or local arterial stiffness. The methods of the invention use any one of a number of magnetic resonance imaging techniques known in the art to acquire image data so as to arrive at these vascular physiological parameters. Also such methods include locating the detector or imaging coil proximal to a single artery and external to the body/specimen. According to one aspect, the methodology determines the central arterial stiffness from image data acquired at the single arterial location. In another aspect, image data is acquired so that one or more of central arterial stiffness, vascular reactivity and/or local arterial stiffness can be determined from the acquired image data alone or in combination with other acquired data/information.

Abstract: Featured are methods for non-invasive assessment of vascular reactivity. The methods of the invention use phase contrast magnetic resonance imaging angiography and use the image data thereby acquired to measure shear rate, radius of the vasculature and flow through the vasculature. According to one aspect, such acquisition of image data occurs before and during, an arterial occlusion and according to another aspect such acquisition of image data occurs before during and after arterial occlusion. The disclosed methods of the invention allow for reproducible, non-invasive diagnosis of early stage indicators of atherosclerosis.

Abstract: An embodiment in accordance with the present invention provides an automated device and method for determining cardiac filling pressure non-invasively. The device includes a computer readable medium programmed to analyze a photoplethysmography signal having a pulse amplitude. The analysis is done to determine a point in time that the pulse amplitude of the photoplethysmography signal does not vary by a predetermined amount over a first predetermined time period. The method also includes displaying instructions for the user to prepare for and begin an expiratory effort. The expiratory effort of the user is compared to a predetermined goal range for expiratory effort, and an indicator of the user's expiratory effort relative to the predetermined goal range is displayed on the user interface.

Abstract: Featured are methods for non-invasive assessment of a vascular physiological parameter including but not limited to central arterial stiffness, vascular reactivity and/or local arterial stiffness. The methods of the invention use any one of a number of magnetic resonance imaging techniques known in the art to acquire image data so as to arrive at these vascular physiological parameters. Also such methods include locating the detector or imaging coil proximal to a single artery and external to the body/specimen. According to one aspect, the methodology determines the central arterial stiffness from image data acquired at the single arterial location. In another aspect, image data is acquired so that one or more of central arterial stiffness, vascular reactivity and/or local arterial stiffness can be determined from the acquired image data alone or in combination with other acquired data/information.

Abstract: Featured are methods and systems for assessing cardiac filing pressure non-invasively. Such methods include, inter alia, arranging a photoplethysmography (PPG) transducer on a finger of a patient and fluidly coupling a pressure transducer to the patient's mouth so that the pressure transducer measures expiratory pressure. The PPG transducer provides an output of a pulse volume signal of cardiac circulatory flow. Such methods also including determining a pulse amplitude ratio, using the pulse volume near the end of the expiratory effort and a baseline pulse volume, and assessing the pulse amplitude ratio so as to determine a filing pressure condition for the heart of the patient.

Abstract: Featured are methods for non-invasive assessment of vascular reactivity. The methods of the invention use phase contrast magnetic resonance imaging angiography and use the image data thereby acquired to measure shear rate, radius of the vasculature and flow through the vasculature. According to one aspect, such acquisition of image data occurs before and during, an arterial occlusion and according to another aspect such acquisition of image data occurs before during and after arterial occlusion. The disclosed methods of the invention allow for reproducible, non-invasive diagnosis of early stage indicators of atherosclerosis.

Abstract: Featured are improved methods for non-invasive assessment of vascular endothelial function. The methods of the invention use phase contrast magnetic resonance imaging angiography to determine wall shear stress before, during, and after an arterial occlusion as well as the resulting endothelial dependent flow mediated dilation. Additionally methods are disclosed which allow for comparison of measurements derived through use of phase contrast magnetic resonance imaging to relate endothelial stimulus and response. The disclosed methods of the invention allow for reproducible, non-invasive diagnosis of early stage indicators of atherosclerosis.