Abstract: A hypodermic syringe is provided which comprises a hollow barrel, a longitudinally slidable and axially rotatable plunger shaft, a sealing means, e.g., a self-resealing rubber cap or sealing gasket, and an integrally-joined cover which includes (i) a charging positioning means for longitudinally moving the shaft within the barrel, (ii) axial rotational means for rotating the shaft of about 180.degree. to a plurality of discharge positions, and (iii) discharging positioning means for longitudinally moving the shaft within the barrel. The hypodermic syringe can only be used once to inject a patient or user with a liquid.

Abstract: A tamper-proof package includes a vessel, closure and locking member having downwardly and outwardly extending tabs of a contrasting color welded to the vessel. The tabs are frangible to break upon twisting of the cap to provide visibly contrasting evidence of tampering observable from above the package.