Patents by Inventor Harshvardhan Mehta
Harshvardhan Mehta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090246225Abstract: Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.Type: ApplicationFiled: December 8, 2008Publication date: October 1, 2009Applicant: MedImmune, LLCInventors: George Robert Trager, George Kemble, Richard M. Schwartz, Harshvardhan Mehta, Vu Truong-Le, Zhongying Chen, Alfred A. Pan, Eric Tsao, Chiaoyin Kathy Wang, Luisa Yee, Palani Balu
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Publication number: 20070161085Abstract: Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.Type: ApplicationFiled: January 30, 2007Publication date: July 12, 2007Applicant: Medlmmune Vaccines, Inc.Inventors: George Trager, George Kemble, Richard Schwartz, Harshvardhan Mehta, Vu Truong-Le, Zhongying Chen, Alfred Pan, Eric Tsao, Chiaoyin Wang, Luisa Yee, Palani Balu
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Publication number: 20050281833Abstract: Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccharide. Also disclosed is a method fore introducing an amine-reactive functionality into a dextran. The method comprises (a) reacting the dextran with an alkylating agent having a functionality that reacts with an hydroxyl group of the dextran thereby forming an alkylated dextran wherein the alkylating agent has an olefin group and (b) treating the alkylated dextran to convert the olefin group to an amine-reactive functionality. A polysaccharide can be conjugated to a biomolecule by carrying out the above method and reacting the amine-reactive functionality with an amine functionality on the biomolecule to produce polysaccharide conjugated to the biomolecule.Type: ApplicationFiled: July 13, 2005Publication date: December 22, 2005Inventors: Rajendra Singh, Harshvardhan Mehta
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Patent number: 6949524Abstract: Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccharide. Also disclosed is a method for introducing an amine-reactive functionality into a dextran. The method comprises (a) reacting the dextran with an alkylating agent having a functionality that reacts with an hydroxyl group of the dextran thereby forming an alkylated dextran wherein the alkylating agent has an olefin group and (b) treating the alkylated dextran to convert the olefin group to an amine-reactive functionality. A polysaccharide can be conjugated to a biomolecule by carrying out the above method and reacting the amine-reactive functionality with an amine functionality on the biomolecule to produce polysaccharide conjugated to the biomolecule.Type: GrantFiled: July 2, 2002Date of Patent: September 27, 2005Assignee: Dade Behring Marburg GmbHInventors: Rajendra Singh, Harshvardhan Mehta
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Publication number: 20040265987Abstract: Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.Type: ApplicationFiled: February 25, 2004Publication date: December 30, 2004Applicant: Medlmmune Vaccines, Inc.Inventors: George Robert Trager, George Kemble, Richard M. Schwartz, Harshvardhan Mehta, Vu Truong-Le, Zhongying Chen, Alfred A. Pan, Eric Tsao, Chiaoyin Kathy Wang, Luisa Yee, Palani Balu
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Publication number: 20030027788Abstract: Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccharide. Also disclosed is a method for introducing an amine-reactive functionality into a dextran. The method comprises (a) reacting the dextran with an alkylating agent having a functionality that reacts with an hydroxyl group of the dextran thereby forming an alkylated dextran wherein the alkylating agent has an olefin group and (b) treating the alkylated dextran to convert the olefin group to an amine-reactive functionality. A polysaccharide can be conjugated to a biomolecule by carrying out the above method and reacting the amine-reactive functionality with an amine functionality on the biomolecule to produce polysaccharide conjugated to the biomolecule.Type: ApplicationFiled: July 2, 2002Publication date: February 6, 2003Inventors: Rajendra Singh, Harshvardhan Mehta
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Publication number: 20020193586Abstract: Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccharide. Also disclosed is a method for introducing an amine-reactive functionality into a dextran. The method comprises (a) reacting the dextran with an alkylating agent having a functionality that reacts with an hydroxyl group of the dextran thereby forming an alkylated dextran wherein the alkylating agent has an olefin group and (b) treating the alkylated dextran to convert the olefin group to an amine-reactive functionality. A polysaccharide can be conjugated to a biomolecule by carrying out the above method and reacting the amine-reactive functionality with an amine functionality on the biomolecule to produce polysaccharide conjugated to the biomolecule.Type: ApplicationFiled: May 18, 1999Publication date: December 19, 2002Inventors: RAJENDRA SINGH, HARSHVARDHAN MEHTA
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Patent number: 6489309Abstract: Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccharide. Also disclosed is a method for introducing an amine-reactive functionality into a dextran. The method comprises (a) reacting the dextran with an alkylating agent having a functionality that reacts with an hydroxyl group of the dextran thereby forming an alkylated dextran wherein the alkylating agent has an olefin group and (b) treating the alkylated dextran to convert the olefin group to an amine-reactive functionality. A polysaccharide can be conjugated to a biomolecule by carrying out the above method and reacting the amine-reactive functionality with an amine functionality on the biomolecule to produce polysaccharide conjugated to the biomolecule.Type: GrantFiled: May 18, 1999Date of Patent: December 3, 2002Assignee: Dade Behring Marburg GmbHInventors: Rajendra Singh, Harshvardhan Mehta
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Patent number: 5929049Abstract: Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccharide. Also disclosed is a method for introducing an amine-reactive functionality into a dextran. The method comprises (a) reacting the dextran with an alkylating agent having a functionality that reacts with an hydroxyl group of the dextran thereby forming an alkylated dextran wherein the alkylating agent has an olefin group and (b) treating the alkylated dextran to convert the olefin group to an amine-reactive functionality. A polysaccharide can be conjugated to a biomolecule by carrying out the above method and reacting the amine-reactive functionality with an amine functionality on the biomolecule to produce polysaccharide conjugated to the biomolecule.Type: GrantFiled: August 8, 1997Date of Patent: July 27, 1999Assignee: Dade Behring Marburg GmbHInventors: Rajendra Singh, Harshvardhan Mehta