Patents by Inventor Haruyuki Nishida
Haruyuki Nishida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230265104Abstract: A compound of the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof has a superior inhibitory activity on cancer cell proliferation.Type: ApplicationFiled: July 16, 2021Publication date: August 24, 2023Applicant: PRISM BIOLAB CO., LTD.Inventors: Hajime TAKASHIMA, Eiji HONDA, Tomonori TAGURI, Jun OZAWA, Haruyuki NISHIDA, Yoichiro HIROSE, Keisuke KIMURA
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Patent number: 8993598Abstract: The present invention relates to a compound represented by the formula: wherein A is pyridyl group having at least one substituent wherein R1, R2 and R3 are each a hydrogen atom, a halogen atom, a C1-6 alkyl group optionally substituted by halogen or a C1-6 alkoxy group optionally substituted by halogen, R4 and R6 are each a hydrogen atom, a halogen atom or a C1-6 alkyl group optionally substituted by halogen, R5 is a hydrogen atom, a halogen atom, a C1-6 alkyl group optionally substituted by halogen or a C1-6 alkoxy group optionally substituted by halogen, and R7 is a hydrogen atom or a C1-6 alkyl group optionally substituted by halogen or a salt thereof, or a pharmaceutical composition containing the same.Type: GrantFiled: October 1, 2013Date of Patent: March 31, 2015Assignee: Takeda Pharmaceutical Company LimitedInventors: Haruyuki Nishida, Yasuyoshi Arikawa, Ikuo Fujimori
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Patent number: 8969387Abstract: The present invention relates to a compound represented by the formula: wherein A is pyridyl group having at least one substituent wherein R1, R2 and R3 are each a hydrogen atom, a halogen atom, a C1-6 alkyl group optionally substituted by halogen or a C1-6 alkoxy group optionally substituted by halogen, R4 and R6 are each a hydrogen atom, a halogen atom or a C1-6 alkyl group optionally substituted by halogen, R5 is a hydrogen atom, a halogen atom, a C1-6 alkyl group optionally substituted by halogen or a C1-6 alkoxy group optionally substituted by halogen, and R7 is a hydrogen atom or a C1-6 alkyl group optionally substituted by halogen or a salt thereof, or a pharmaceutical composition containing the same.Type: GrantFiled: August 26, 2009Date of Patent: March 3, 2015Assignee: Takeda Pharmaceutical Company LimitedInventors: Haruyuki Nishida, Yasuyoshi Arikawa, Ikuo Fujimori
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Patent number: 8933105Abstract: The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity, which is represented by the formula (I) wherein R1 is an optionally substituted cyclic group, R2 is a substituent, R3 is an optionally substituted alkyl group, an acyl group, an optionally substituted hydroxy group, an optionally substituted amino group, a halogen atom, a cyano group or a nitro group, R4 and R5 are each a hydrogen atom, an optionally substituted alkyl group, an acyl group, an optionally substituted hydroxy group, an optionally substituted amino group, a halogen atom, a cyano group or a nitro group, R6 and R6? are each a hydrogen atom or an alkyl group, and n is an integer of 0-3, or a salt thereof.Type: GrantFiled: February 26, 2008Date of Patent: January 13, 2015Assignee: Takeda Pharmaceutical Company LimitedInventors: Masahiro Kajino, Haruyuki Nishida, Yasuyoshi Arikawa, Keizo Hirase, Koji Ono
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Patent number: 8895588Abstract: Provided is a compound having a superior acid secretion suppressive action, antiulcer activity and the like. A compound represented by the formula wherein R1 is a substituent, R2 is (i) a hydrogen atom, (ii) a C1-6 alkyl group optionally having a halogen atom or (iii) a cyano group, R3 is (i) a hydrogen atom, (ii) a halogen atom, (iii) a cyano group, (iv) a C1-6 alkyl group optionally having a halogen atom or a C1-6 alkoxy group optionally having a halogen atom, one of R2 and R3 is a hydrogen atom, and the other is a substituent other than a hydrogen atom, or a salt thereof.Type: GrantFiled: March 25, 2010Date of Patent: November 25, 2014Assignee: Takeda Pharmaceutical Company LimitedInventors: Haruyuki Nishida, Ikuo Fujimori
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Patent number: 8686010Abstract: The present invention provides a compound having a superior acid secretion inhibitory action, an antiulcer activity and the like.Type: GrantFiled: August 5, 2011Date of Patent: April 1, 2014Assignee: Takeda Pharmaceutical Company LimitedInventors: Atsushi Hasuoka, Terufumi Takagi, Haruyuki Nishida
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Publication number: 20140031393Abstract: The present invention relates to a compound represented by the formula: wherein A is pyridyl group having at least one substituent wherein R1, R2 and R3 are each a hydrogen atom, a halogen atom, a C1-6 alkyl group optionally substituted by halogen or a C1-6 alkoxy group optionally substituted by halogen, R4 and R6 are each a hydrogen atom, a halogen atom or a C1-6 alkyl group optionally substituted by halogen, R5 is a hydrogen atom, a halogen atom, a C1-6 alkyl group optionally substituted by halogen or a C1-6 alkoxy group optionally substituted by halogen, and R7 is a hydrogen atom or a C1-6 alkyl group optionally substituted by halogen or a salt thereof, or a pharmaceutical composition containing the same.Type: ApplicationFiled: October 1, 2013Publication date: January 30, 2014Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Haruyuki Nishida, Yasuyoshi Arikawa, Ikuo Fujimori
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Patent number: 8592597Abstract: The present invention relates to a compound represented by the formula: wherein A is pyridyl group having at least one substituent wherein R1, R2 and R3 are each a hydrogen atom, a halogen atom, a C1-6 alkyl group optionally substituted by halogen or a C1-6 alkoxy group optionally substituted by halogen, R4 and R6 are each a hydrogen atom, a halogen atom or a C1-6 alkyl group optionally substituted by halogen, R5 is a hydrogen atom, a halogen atom, a C1-6 alkyl group optionally substituted by halogen or a C1-6 alkoxy group optionally substituted by halogen, and R7 is a hydrogen atom or a C1-6 alkyl group optionally substituted by halogen or a salt thereof, or a pharmaceutical composition containing the same.Type: GrantFiled: August 26, 2009Date of Patent: November 26, 2013Assignee: Takeda Pharmaceutical Company LimitedInventors: Haruyuki Nishida, Yasuyoshi Arikawa, Ikuo Fujimori
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Patent number: 8436187Abstract: The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.Type: GrantFiled: June 8, 2011Date of Patent: May 7, 2013Assignee: Takeda Pharmaceutical Company LimitedInventors: Masahiro Kajino, Atsushi Hasuoka, Haruyuki Nishida
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Patent number: 8415368Abstract: The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.Type: GrantFiled: January 26, 2009Date of Patent: April 9, 2013Assignee: Takeda Pharmaceutical Company LimitedInventors: Masahiro Kajino, Atsushi Hasuoka, Haruyuki Nishida
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Patent number: 8338461Abstract: The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.Type: GrantFiled: March 1, 2011Date of Patent: December 25, 2012Assignee: Takeda Pharmaceutical Company LimitedInventors: Masahiro Kajino, Atsushi Hasuoka, Haruyuki Nishida
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Patent number: 8338462Abstract: The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl pup, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.Type: GrantFiled: June 8, 2011Date of Patent: December 25, 2012Assignee: Takeda Pharmaceuticals Company LimitedInventors: Masahiro Kajino, Atsushi Hasuoka, Haruyuki Nishida
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Patent number: 8334301Abstract: Provided is a compound having a superior acid secretion suppressive action, which shows an antiulcer activity and the like.Type: GrantFiled: September 24, 2008Date of Patent: December 18, 2012Assignee: Takeda Pharmaceutical Company LimitedInventors: Haruyuki Nishida, Yasuyoshi Arikawa, Keizo Hirase
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Patent number: 8299261Abstract: The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.Type: GrantFiled: June 8, 2011Date of Patent: October 30, 2012Assignee: Takeda Pharmaceutical Company LimitedInventors: Masahiro Kajino, Atsushi Hasuoka, Haruyuki Nishida
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Publication number: 20120095057Abstract: Provided is a compound having a superior acid secretion suppressive action, antiulcer activity and the like. A compound represented by the formula wherein R1 is a substituent, R2 is (i) a hydrogen atom, (ii) a C1-6 alkyl group optionally having a halogen atom or (iii) a cyano group, R3 is (i) a hydrogen atom, (ii) a halogen atom, (iii) a cyano group, (iv) a C1-6 alkyl group optionally having a halogen atom or (v) a C1-6 alkoxy group optionally having a halogen atom, one of R2 and R3 is a hydrogen atom, and the other is a substituent other than a hydrogen atom, or a salt thereof.Type: ApplicationFiled: March 25, 2010Publication date: April 19, 2012Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Haruyuki Nishida, Ikuo Fujimori
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Publication number: 20120088797Abstract: The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl pup, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.Type: ApplicationFiled: June 8, 2011Publication date: April 12, 2012Applicant: Takeda Pharmaceutical Company LimitedInventors: Masahiro KAJINO, Atsushi HASUOKA, Haruyuki NISHIDA
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Publication number: 20110301173Abstract: The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.Type: ApplicationFiled: June 8, 2011Publication date: December 8, 2011Applicant: Takeda Pharmaceutical Company LimitedInventors: Masahiro Kajino, Atsushi Hasuoka, Haruyuki Nishida
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Publication number: 20110301174Abstract: The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl pup, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.Type: ApplicationFiled: June 8, 2011Publication date: December 8, 2011Applicant: Takeda Pharmaceutical Company LimitedInventors: Masahiro Kajino, Atsushi Hasuoka, Haruyuki Nishida
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Publication number: 20110288040Abstract: The present invention provides a compound having a superior acid secretion inhibitory action, an antiulcer activity and the like.Type: ApplicationFiled: August 5, 2011Publication date: November 24, 2011Applicant: Takeda Pharmaceutical Company LimitedInventors: Atsushi Hasuoka, Terufumi Takagi, Masahiro Kajino, Haruyuki Nishida
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Patent number: 7994205Abstract: The present invention provides an aryl- or heteroaryl compound represented by the formula (Ia) or (Ib) wherein each symbol is as defined in the specification, or a salt thereof, or a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier. The compound has superior acid secretion inhibitory action, an antiulcer activity and the like.Type: GrantFiled: March 30, 2007Date of Patent: August 9, 2011Assignee: Takeda Pharmaceutical Company LimitedInventors: Atsushi Hasuoka, Terufumi Takagi, Haruyuki Nishida