Patents by Inventor Harvey R. Gralnick

Harvey R. Gralnick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hybridomas and monoclonal antibodies that speifically bind to GPIB on platelets and inhibit the binding of thrombin to platelets
    Patent number: 5486361
    Abstract: Monoclonal antibodies which specifically bind to glycoprotein Ib are described. These antibodies completely inhibit the binding of thrombin to platelets, thereby totally inhibiting the activation of platelets by thrombin. The antibodies also completely inhibit platelet aggregation and also significantly inhibit adhesion of platelets to a subendothelial arterial surface in an ex vivo model system.
    Type: Grant
    Filed: October 25, 1993
    Date of Patent: January 23, 1996
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventor: Harvey R. Gralnick
  • Anti-platelet monoclonal antibody
    Patent number: 5366865
    Abstract: A method for producing novel monoclonal antibodies against purified platelets are provided. A monoclonal antibodies which inhibits platelet reactions with collagen or collagenous surfaces is described. A new method of detecting and treating tumor metastatis is described.
    Type: Grant
    Filed: April 6, 1989
    Date of Patent: November 22, 1994
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventor: Harvey R. Gralnick
  • Monoclonal antibody against human platelets
    Patent number: 5332670
    Abstract: A novel anti-platelet monoclonal antibody which is without effect on inactivated platelets, but which augments platelet aggregation after minimal perturbation of the platelets, and various applications of the monoclonal antibody are described.
    Type: Grant
    Filed: January 7, 1992
    Date of Patent: July 26, 1994
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventor: Harvey R. Gralnick
  • Anti-platelet monoclonal antibody
    Patent number: 5231025
    Abstract: A unique anti-platelet monoclonal antibody which binds to human platelet glycoprotein IV, and various utilities of the monoclonal antibody are described.
    Type: Grant
    Filed: November 3, 1989
    Date of Patent: July 27, 1993
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventor: Harvey R. Gralnick