Abstract: A VMD system and method uses an aspirator to generate a vacuum pressure for drawing permeate from a membrane module. The aspirator generates the vacuum pressure by receiving and passing a circulating liquid and combines the permeate with the circulating liquid such that the permeate condensates in the circulating liquid. Using an aspirator (e.g., instead of a vacuum pump) allows a more efficient and cost-effective operation of the VMD system and method, particularly in a desalination application. A VMD system and method using an aspirator may be used in desalination and other applications including, without limitation, environmental cleanup (e.g., removal of volatile organic chemicals from water) and food and medical applications.